Apr 15, 2015

Giant proteins determine properties of neurons

Giant membrane-associated proteins called ankyrins extend into the cytoplasm to arrange and stabilize microtubules in axons and synapses. This determines not only the diameter and hence the functional properties of axons, but also the size, function and stability of synapses. This mechanism underlying the control of neuronal dimensions, functional properties and connectivity was elucidated by Jan Pielage and his group at the Friedrich Miescher Institute for Biomedical Research (FMI). Their findings have been published in Developmental Cell. Read more

Apr 06, 2015

Detailing heterochromatin formation at the onset of life

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Mar 26, 2015

How genes are permanently silenced by small RNAs

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Mar 20, 2015

A spotlight on protein translation

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Next seminars & events

Apr 20, 2015. Time: 11.00  FMI Room 530  Add to my calendar  Register for this event

Distant-acting enhancers in craniofacial development
Catia Attanasio, University of Lausanne

Apr 20, 2015. Time: 14.00  FMI Room 530  Add to my calendar  Register for this event

The functions of Y-Box binding proteins in Caenorhabditis Elegans
Andreas Arnold

Apr 21, 2015. Time: 13.30  FMI Room 530  Add to my calendar  Register for this event

Feedback control of mammalian cell differentiation
Mary N. Teruel, Dept. of Chemical and Systems Biology, Stanford University, CA USA

Apr 22, 2015. Time: 13.30  FMI Room 530  Add to my calendar  Register for this event

Quantifying the central dogma: dynamic profiling of the protein life cycle in response to pathogens
Marko Jovanovic, Broad Institute of MIT and Harvard University, Cambridge, MA, USA

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Recent Publications

Genoud C, Houades V, Kraftsik R, Welker E, Giaume C Proximity of excitatory synapses and astroglial gap junctions in layer IV of the mouse barrel cortex Neuroscience. 2015 Apr; 291:241-9

Stephan R, Goellner B, Moreno E, Frank CA, Hugenschmidt T, Genoud C1 Aberle H, Pielage J Hierarchical Microtubule Organization Controls Axon Caliber and Transport and Determines Synaptic Structure and Stability Dev Cell. 2015 Apr; 33(1)5-21

Filipowicz W, Sonenberg N The long unfinished march towards understanding microRNA-mediated repression RNA. 2015 Apr; 21(4):519-24

Kowalik KM, Shimada Y, Flury V, Stadler MB, Batki J, Bühler M The Paf1 complex represses small-RNA-mediated epigenetic gene silencing Nature. 2015 Apr; 520(7546):248-52

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