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Dec 19, 2014

Two-armed control of ATR, a master regulator of the DNA damage checkpoint

Our genomes encounter DNA damaging events continuously. As damage accumulates, our cells react and stop the cell division process, giving repair mechanisms time to act. To achieve this, two master protein kinases called ATR and ATM, encoded by well-known tumor suppressor genes, activate a cascade of phosphorylation events. The downstream readout of these checkpoint cascades is well characterized, yet the regulation of the master kinase itself has remained enigmatic. Nicole Hustedt, a student in the laboratory of Susan Gasser, examined this question with a combination of sophisticated yeast genetics and phosphoproteomics. She found that the key regulator of the yeast Mec1 kinase, the yeast ATR homologue, is a phosphatase that directly reverses the modification of many damage-induced Mec1 kinase targets. The identified phosphatase, called PP4, not only dephosphorylates Mec1 targets, but directly interacts with the kinase, fine-tuning its activity during the cell cycle. Read more

Dec 11, 2014

FMI scientists secure funding for two SystemsX.ch projects

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Nov 28, 2014

Two former FMI PhD students honored for outstanding PhD theses

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Nov 21, 2014

Georg Keller receives SNSF Starting Grant

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Next seminars & events

Jan 13, 2015. Time: 12:15  FMI Room 530  Add to my calendar  Register for this event

Cdk6 novel insights on an old kinase
Veronika Sexl, University of Veterinary Medicine, Vienna, Austria

Jan 15, 2015. Time: 16.00  FMI Room 530  Add to my calendar  Register for this event

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Francois Spitz, Developmental Biology Unit, EMBL, Heidelberg, Germany

Jan 19, 2015. Time: 12:00  FMI Room 530  Add to my calendar  Register for this event

Towards personalized hormonal therapy selection in breast cancer through genomic profiling
Wilbert Zwart, The Netherlands Cancer Institute, Amsterdam, The Netherlands

Jan 20, 2015. Time: 12.15  FMI Room 530  Add to my calendar  Register for this event

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Cedric Blanpain, Université Libre de Bruxelles, Belgium

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Recent Publications

Sreenivasan V, Karmakar K, Rijli FM, Petersen CC Parallel pathways from motor and somatosensory cortex for controlling whisker movements in mice Eur J Neurosci. 2014 Dec; [Epub ahead of print]

Arnold A, Rahman MM, Lee MC, Muehlhaeusser S, Katic I, Gaidatzis D, Hess D, Scheckel C, Wright JE, Stetak A, Boag PR, Ciosk R Functional characterization of C. elegans Y-box-binding proteins reveals tissue-specific functions and a critical role in the formation of polysomes Nucleic Acids Res. 2014 Dec; 42(21):13353-69

Lüthi A, Lüscher C Pathological circuit function underlying addiction and anxiety disorders Nat Neurosci. 2014 Dec; 17(12):1635-1643

Szikra T, Trenholm S, Drinnenberg A, Jüttner J, Raics Z, Farrow K, Biel M, Awatramani G, Clark DA, Sahel JA, da Silveira RA, Roska B Rods in daylight act as relay cells for cone-driven horizontal cell-mediated surround inhibition Nat Neurosci. 2014 Dec; 17(12):1728-35

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