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Oct 30, 2014

New opportunities for anti-viral intervention

Patrick Matthias from the FMI, together with scientists from the ETH Zurich, has discovered that the influenza virus takes advantage of the cellular process that deals with misfolded proteins, to crack open its capsid. They could show that the viral capsid, by carrying unanchored ubiquitin, mimics misfolded protein aggregates. This form of ubiquitin is recognized with high affinity by a cytoplasmic enzyme, HDAC6, which is therefore recruited to the envelope encasing the viral genome. In addition, HDAC6 binds to cytoplasmic motor proteins, dynein and myosin. These four proteins create a molecular module with HDAC6 at its center. The motor proteins promote movement along microtubules and actin filaments, thereby generating mechanical stress that pulls the viral capsid apart. These unexpected findings have just been published in Science. Read more

Oct 29, 2014

Barbara Hohn receives Austrian Honorary Medal, Silvia Arber the City of Basel Science Award

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Oct 23, 2014

Stopping anti-CCL2 breast cancer treatment aggravates the disease

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Oct 14, 2014

FMI postdocs honored for outstanding achievements

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Next seminars & events

Nov 03, 2014. Time: 11.00  FMI Room 530  Add to my calendar  Register for this event

Introduction to Computational Neuroscience
Single cell synaptic integration in dendrites

Tiago Branco, MRC Laboratory of Molecular Biology, Cambridge, UK

Nov 03, 2014. Time: 17.00  FMI Room 530  Add to my calendar  Register for this event

Synaptic integration in a circuit controlling feeding and innate escape behaviour
Tiago Branco, MRC Laboratory of Molecular Biology, Cambridge, UK

Nov 06, 2014. Time: 10.00  FMI Room 530  Add to my calendar  Register for this event

Developmental control of replication timing and chromosome architecture
David Gilbert, Florida State University, Tallahassee, FL, USA

Nov 06, 2014. Time: 11.30  FMI Room 530  Add to my calendar  Register for this event

Migration of neuronal and immune cells in forebrain wiring
Sonia Garel, Ecole Normale Superieure, Paris, France

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Recent Publications

Szikra T, Trenholm S, Drinnenberg A, Jüttner J, Raics Z, Farrow K, Biel M, Awatramani G, Clark DA, Sahel JA, da Silveira RA, Roska B Rods in daylight act as relay cells for cone-driven horizontal cell-mediated surround inhibition Nat Neurosci. 2014 Oct; [Epub ahead of print]

Banerjee I, Miyake Y, Nobs SP, Schneider C, Horvath P, Kopf M, Matthias P, Helenius A, Yamauchi Y Influenza A virus uses the aggresome processing machinery for host cell entry Science. 2014 Oct; 346(6208):473-7

Bonapace L, Coissieux MM, Wyckoff J, Mertz KD, Varga Z, Junt T, Bentires-Alj M Cessation of CCL2 inhibition accelerates breast cancer metastasis by promoting angiogenesis Nature. 2014 Oct; [Epub ahead of print]

Caroni P, Chowdhury A, Lahr M Synapse rearrangements upon learning: from divergent-sparse connectivity to dedicated sub-circuits Trends Neurosci. 2014 Oct; 37(10):604-614

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