Aug 12, 2015

Common breast cancer mutation induces multipotency and tumor heterogeneity

Understanding how different cell populations arise within a tumor - so-called tumor heterogeneity - is widely regarded as a major challenge for cancer biology. Mohamed Bentires-Alj and his group at the FMI have discovered how the most frequent mutation in human breast cancer leads to tumor heterogeneity. The PI3-kinase mutation forces cells back into a dedifferentiated, stem-like state from which tumors containing cells of various lineages can develop. These results have been published in Nature. Read more

Aug 03, 2015

Building a research network at the LMB-FMI Student Symposium

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Jul 13, 2015

The hidden treasure in RNA-seq

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Jul 03, 2015

Smart viruses enlighten vision in the brain

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Next seminars & events

Sep 01, 2015. Time: 12.30  FMI Room 530  Add to my calendar  Register for this event

Basel Breast Consortium Tandem Seminar Series
Nanomechanical characterization of tumors and implications for clinical practice
2. Global gene expression analysis of tumor stroma interaction: Effects with clinical relevance

1. Ellen Obermann, University Hospital, Basel / Marija Plodinec, Biozentrum, University of Basel
2. Martin Buess, Claraspital, Basel
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Sep 08, 2015. Time: 12.15  FMI Room 530  Add to my calendar  Register for this event

Defining lineage specification during mammary gland development
Silvia Fre, Institute Curie, Paris, France

Sep 10, 2015. Time: 11.30  FMI Room 530  Add to my calendar  Register for this event

Ensemble coding and plasticity in the mammalian olfactory system
Alan Carleton, Medical Sciences, University of Geneva

Sep 21, 2015. Time: 14.00  FMI Room 530  Add to my calendar  Register for this event

Studies on breast cancer: HDAC11 in ER-positive breast cancer and memo in metastasis
Anna Frei

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Recent Publications

Koren S, Reavie L, do Couto JP, De Silva D, Stadler MB, Roloff T, Britschgi A, Eichlisberger T, Kohler H, Aina O, Cardiff RD, Bentires-Alj M PIK3CAH1047R induces multipotency and multi-lineage mammary tumours Nature. 2015 Aug; [Epub ahead of print]

Marcomini I, Gasser SM Nuclear organization in DNA end processing: Telomeres vs double-strand breaks DNA Repair (Amst). 2015 Aug; 32:134-40

Wanner AA, Kirschmann MA, Genoud C Challenges of microtome-based serial block-face scanning electron microscopy in neuroscience J Microsc. 2015 Aug; 259(2):137-42

Flemr M, Bühler M Single-Step Generation of Conditional Knockout Mouse Embryonic Stem Cells Cell Rep. 2015 Jul; 12(4):709-16

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