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FMI

Oct 23, 2014

Stopping anti-CCL2 breast cancer treatment aggravates the disease

Mohamed Bentires-Alj and his team at the FMI together with scientists from the Novartis Institutes for BioMedical Research (NIBR) show in a study published today in Nature that a promising therapeutic approach for metastatic breast cancer elicits deleterious effects after cessation of the treatment. Stopping CCL2 inhibition paradoxically increases metastasis formation and leads to premature death thus thwarting the initially beneficial effects of the treatment. This has implications for the design of therapies targeting these processes and indicates that therapeutic approaches to inactivate the chemokine CCL2 should be administered with extreme caution. Read more

Oct 14, 2014

FMI postdocs honored for outstanding achievements

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Sep 18, 2014

Controlling the transition between generations

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Aug 28, 2014

New functions for chromatin remodelers

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» News archive

Next seminars & events

Oct 28, 2014. Time: 11.00  FMI Room 539  Add to my calendar  Register for this event

A neural circuit mechanism for triggering and setting the strength of fear memories
Joshua Johansen, Riken Brain Institute, Japan

Oct 30, 2014. Time: 10.00  FMI Room 530  Add to my calendar  Register for this event

Epigenetics and chromosome folding
Giacomo Cavalli, Institute of Human Genetics - CNRS, Montpellier, France

Oct 30, 2014. Time: 11.30  FMI Room 530  Add to my calendar  Register for this event

Spike-based neuromorphic sensors and applications
Tobi Delbrück, Institute for Neuroinformatics, ETH Zürich

Oct 30, 2014. Time: 17.15  FMI Room 530  Add to my calendar  Register for this event

Molecular basis of translation regulation by small RNA binding proteins
Frédéric Allain, Institute of Molecular Biology and Biophysics, ETH Hönggerberg, Zurich

» More FMI seminars & events

Recent Publications

Bonapace L, Coissieux MM, Wyckoff J, Mertz KD, Varga Z, Junt T, Bentires-Alj M Cessation of CCL2 inhibition accelerates breast cancer metastasis by promoting angiogenesis Nature. 2014 Oct; [Epub ahead of print]

Caroni P, Chowdhury A, Lahr M Synapse rearrangements upon learning: from divergent-sparse connectivity to dedicated sub-circuits Trends Neurosci. 2014 Oct; 37(10):604-614

Ramos P, Bentires-Alj M Mechanism-based cancer therapy: resistance to therapy, therapy for resistance Oncogene. 2014 Sep; [Epub ahead of print]

Krebs A, Dessus-Babus S, Burger L, Schübeler D High-throughput engineering of a mammalian genome reveals building principles of methylation states at CG rich regions Elife. 2014 Sep; [Epub ahead of print]

» More FMI publications


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