Aug 28, 2014

New functions for chromatin remodelers

Large molecular motors consisting of up to a dozen different proteins regulate access to the genome, which is essential for the transcription of genes and for the repair of DNA damage. Susan Gasser and her team now reveal a new twist in the activity of such remodelers in the nucleus. In a recent paper in Molecular Cell they show that two related chromatin remodelers help transport broken DNA strands to specific sites in the nucleus for repair. Given the loss of genomic integrity that accompanies cancer and aging, it is not surprising to find that related remodelers are mutated early in the progression of human cancer. Read more

Aug 14, 2014

Crystal structure of COP9 signalosome elucidated

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Jul 29, 2014

Nancy Hynes elected President of the Scientific Board of the Swiss Cancer League

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Jul 17, 2014

Mechanism of action of thalidomide elucidated

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Next seminars & events

Sep 23, 2014. Time: 12.15  FMI Room 530  Add to my calendar  Register for this event

Brown adipose tissue - formation and function
Christian Wolfrum, Laboratory of Translational Nutrition Biology, ETH Zürich

Sep 24, 2014. Time: 10:00  FMI Room 530  Add to my calendar  Register for this event

Cellular responses to replication stress in yeast and human cells
PHilippe Pasero, CNRS Montpellier, France

Sep 24, 2014. Time: 13.00  FMI Room 530  Add to my calendar  Register for this event

Regulation of Mec1(ATR) signaling in budding yeast
Nicole Hustedt

Sep 25, 2014. Time: 10.00  FMI Room 530  Add to my calendar  Register for this event

Mechanisms of heterochromatin positioning in the nucleus
Irina Solovei, Ludwig-Maximilians University, Munich, Germany

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Recent Publications

Hendaoui I, Tucker RP, Zingg D, Bichet S, Schittny J, Chiquet-Ehrismann R Tenascin-C is required for normal Wnt/ß-catenin signaling in the whisker follicle stem cell niche Matrix Biol. 2014 Sep; [Epub ahead of print]

Lalevée S, Lapaire O, Bühler M miR455 is linked to hypoxia signaling and is deregulated in preeclampsia Cell Death Dis. 2014 Sep; 5:e1408

Tocchini C, Keusch JJ, Miller SB, Finger S, Gut H, Stadler MB, Ciosk R The TRIM-NHL Protein LIN-41 Controls the Onset of Developmental Plasticity in Caenorhabditis elegans PLoS Genet. 2014 Aug; 10(8):e1004533

Horigome C, Oma Y, Konishi T, Schmid R, Marcomini I, Hauer MH, Dion V, Harata M, Gasser SM SWR1 and INO80 Chromatin Remodelers Contribute to DNA Double-Strand Break Perinuclear Anchorage Site Choice Mol Cell. 2014 Aug; 55(4):626-39

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