Oct 10, 2016

Epigenetic repression suppresses genomic instability

Susan Gasser and her group at the FMI have found the pathway through which eukaryotic organisms protect their genomes from rearrangements and deletions that arise from repetitive DNA. Human genomes, like those of simple animals like worms, are filled with repeat sequences, many being remnants of viral infections of the distant past. This repetitive DNA is usually kept silent. The transcription of these repeats into RNA was shown by the Gasser laboratory to generate toxic hybrids between RNA and DNA. These aberrant "R-loops" can lead to deletions and insertions, endangering the integrity of the genome. Keeping them silent is the task of a universally conserved epigenetic modification on histone H3: the methylation of lysine 9. While this modification also silences genes during development, is was shown to be dispensible for tissue differentiation in C. elegans; instead it serves to protect the genome from repeat-driven mutation. Read more

Sep 24, 2016

Controlling cell-fate decisions

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Sep 19, 2016

What you see is not always what you get

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Sep 08, 2016

Cloëtta Prize awarded to Andreas Lüthi

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Next seminars & events

Oct 20, 2016. Time: 11.30  FMI Room 530  Add to my calendar  Register for this event

Relating Dynamics to Computation: dimension-specific computation in cortical activity
Shaul Druckmann, Howard Hughes Medical Institute, Janelia Research Campus, Ashburn, VA, USA

Oct 20, 2016. Time: 17:15  FMI Room 530  Add to my calendar  Register for this event

Dissecting functions and mechanisms of vertebrate lncRNAs
Alena Shkumatava, Institut Curie, Paris, France

Oct 21, 2016. Time: 10.15  FMI Room 530  Add to my calendar  Register for this event

Spatial organization of the genome and the interplay with proteins
Dieter W. Heermann, Institute for Theoretical Physics, University of Heidelberg, Germany

Oct 25, 2016. Time: 10:00  FMI Room 530  Add to my calendar  Register for this event

Visualizing translation regulation in live cells
Marvin E. Tanenbaum, The Hubrecht Institute, Utrecht, The Netherlands

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Recent Publications

Nestorov P, Hotz HR, Liu Z, Peters AH Dynamic expression of chromatin modifiers during developmental transitions in mouse preimplantation embryos Sci Rep. 2016 Sep; 5:14347

Miki TS, Carl SH, Stadler MB, Großhans H XRN2 Autoregulation and Control of Polycistronic Gene Expresssion in Caenorhabditis elegans PLoS Genet. 2016 Sep; 12(9):e1006313

Fiser A, Mahringer D, Oyibo HK, Petersen AV, Leinweber M, Keller GB Experience-dependent spatial expectations in mouse visual cortex Nat Neurosci. 2016 Sep; [Epub ahead of print]

Seelk S, Adrian-Kalchhauser I, Hargitai B, Hajduskova M, Gutnik S, Tursun B, Ciosk R Increasing Notch signaling antagonizes PRC2-mediated silencing to promote reprograming of germ cells into neurons Elife. 2016 Sep; [Epub ahead of print]

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