Sep 01, 2015

An important shortcut to models of disease

Marc Bühler and his group at the FMI have developed a new and more efficient way to generate embryonic stem cells in which a given gene can be deleted at will, so called conditional knockout cells. They used the engineered nuclease TALEN and a reporter to enrich cells that have integrated defined sequences into the genome through homologous recombination. This refined method makes the use of animals for the generation of conditional knockout cells obsolete. It will also reduce the number of animals required to establish mouse models of disease dramatically. Their new method is therefore in line with 3R efforts around the world. Read more

Aug 12, 2015

Common breast cancer mutation induces multipotency and tumor heterogeneity

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Aug 03, 2015

Building a research network at the LMB-FMI Student Symposium

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Jul 13, 2015

The hidden treasure in RNA-seq

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Next seminars & events

Sep 08, 2015. Time: 12.15  FMI Room 530  Add to my calendar  Register for this event

Defining lineage specification during mammary gland development
Silvia Fre, Institute Curie, Paris, France

Sep 10, 2015. Time: 11.30  FMI Room 530  Add to my calendar  Register for this event

Ensemble coding and plasticity in the mammalian olfactory system
Alan Carleton, Medical Sciences, University of Geneva

Sep 21, 2015. Time: 14.00  FMI Room 530  Add to my calendar  Register for this event

Studies on breast cancer: HDAC11 in ER-positive breast cancer and memo in metastasis
Anna Frei

Sep 24, 2015. Time: 11:30  FMI Room 530  Add to my calendar  Register for this event

Control of forebrain activity and behavior by the intralaminar and midline thalamic nuclei
Laszlo Acsady, Institute of Experimental Medicine, Budapest, Hungary

» More FMI seminars & events

Recent Publications

Mattout A, Cabianca DS, Gasser SM Chromatin states and nuclear organization in development - a view from the nuclear lamina Genome Biol. 2015 Aug; 16:174

Schmitz-Rohmer D, Probst S, Yang ZZ, Laurent F, Stadler MB, Zuniga A, Zeller R, Hynx D, Hemmings BA, Hergovich A NDR Kinases Are Essential for Somitogenesis and Cardiac Looping during Mouse Embryonic Development PLoS One. 2015 Aug; 10(8) :e0136566

Koren S, Reavie L, do Couto JP, De Silva D, Stadler MB, Roloff T, Britschgi A, Eichlisberger T, Kohler H, Aina O, Cardiff RD, Bentires-Alj M PIK3CAH1047R induces multipotency and multi-lineage mammary tumours Nature. 2015 Aug; [Epub ahead of print]

Marcomini I, Gasser SM Nuclear organization in DNA end processing: Telomeres vs double-strand breaks DNA Repair (Amst). 2015 Aug; 32:134-40

» More FMI publications

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