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Aug 14, 2014

Crystal structure of COP9 signalosome elucidated

Nicolas Thomä and his group at the Friedrich Miescher Institute for Biomedical Research have elucidated the crystal structure of the human COP9 signalosome, an important regulator of protein degradation. The crystal structure, published today on the cover of Nature, provides detailed insights into the molecular architecture of the eight-subunit complex and explains how specificity is achieved. Read more

Jul 29, 2014

Nancy Hynes elected President of the Scientific Board of the Swiss Cancer League

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Jul 17, 2014

Mechanism of action of thalidomide elucidated

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Jul 04, 2014

Inducing visual function

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Next seminars & events

Aug 26, 2014. Time: 12.15  FMI Room 530  Add to my calendar  Register for this event

Circulating tumor cells: Detection, biology and clinical implications
Klaus Pantel, University Medical Center, Hamburg-Eppendorf, Germany

Aug 27, 2014. Time: 10.00  FMI Room 530  Add to my calendar  Register for this event

Deep-tissue imaging with time reversed light
Benjamin Judkewitz, Bioimaging and Neurophotonic Exzellenzcluster, Charité, Berlin, Germany

Aug 28, 2014. Time: 11:30  FMI Room 530  Add to my calendar  Register for this event

Predictive control and internal models in dragonfly interception steering
Anthony Leonardo, Howard Hughes Medical Institute HHMI, Janelia Farm Research Campus, Chevy Chase, MD, USA

Aug 29, 2014. Time: 14.00  FMI Room 530  Add to my calendar  Register for this event

From static structures to molecular movies: pushing the boundaries of X-ray crystallography
Wei Yang, National Institute of Health, Bethesda, MD, USA

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Recent Publications

Lingaraju GM, Bunker RD, Cavadini S, Hess D, Hassiepen U, Renatus M, Fischer ES, Thomä NH Crystal structure of the human COP9 signalosome Nature. 2014 Aug; 512(7513):161-5

Fischer ES, Böhm K, Lydeard JR, Yang H, Stadler MB, Cavadini S, Nagel J, Serluca F, Acker V, Lingaraju GM, Tichkule RB, Schebesta M, Forrester WC, Schirle M, Hassiepen U, Ottl J, Hild M, Beckwith RE, Harper JW, Jenkins JL, Thomä NH Structure of the DDB1-CRBN E3 ubiquitin ligase in complex with thalidomide Nature. 2014 Aug; 512(7512):49-53

Busskamp V, Krol J, Nelidova D, Daum J, Szikra T, Tsuda B, Jüttner J, Farrow K, Gross Scherf B, Patino Alvarez CP, Genoud C, Sothilingam V, Tanimoto N, Stadler M, Seeliger M, Stoffel M, Filipowicz W, Roska B miRNAs 182 and 183 Are Necessary to Maintain Adult Cone Photoreceptor Outer Segments and Visual Function Neuron. 2014 Aug; 83(3):586-600

Jermann P, Hoerner L, Burger L, Schübeler D Short sequences can efficiently recruit histone H3 lysine 27 trimethylation in the absence of enhancer activity and DNA methylation Proc Natl Acad Sci U S A. 2014 Aug; [Epub ahead of print]

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