Feb 05, 2016

Neuroscientists restore cell-to-cell signaling and sociability in autism models

In a showcase biomedical research collaboration, scientists from Novartis and the groups of Andreas Lüthi and Pico Caroni at the FMI uncovered a potential therapeutic approach for autism patients deficient in a protein called Shank3. By inhibiting a second protein called CLK2, the researchers were able to restore cell-to-cell signaling between neurons deficient in Shank3, relieve synaptic deficits in patient derived neurons and improve the social response in a mouse model of the disease. Read more

Jan 29, 2016

Interneuron plasticity ensuring long-term memory formation

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Jan 28, 2016

Three FMI Postdocs awarded with the Pfizer Research Prize 2016

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Jan 19, 2016

Keeping RNases poised for action

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» News archive

Next seminars & events

Feb 16, 2016. Time: 12.15  FMI Room 530  Add to my calendar  Register for this event

Breast cancer heterogeneity: a challenge for treatment decisions
Anne-Lise Borresen-Dale, University of Oslo, Norway

Feb 18, 2016. Time: 11.00  FMI Room 530  Add to my calendar  Register for this event

Publishing in scientific journals: A behind the scenes look at the editorial process at Neuron
Katja Brose, Neuron Editor, Elsevier
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Feb 25, 2016. Time: 13.30  FMI Room 530  Add to my calendar  Register for this event

Position matters: chromatin anchoring stabilizes an induced cell fate
Adriana Gonzalez

Feb 29, 2016. Time: 16.15  Add to my calendar

University of Basel G&D Seminar
Planar cell polarity/PCP signaling: a cell's compass during development and organogenesis

Marek Mlodzik, Icahn School of Medicine at Mount Sinai, New York, NY, USA

for details see attached announcement
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Recent Publications

Fischer ES, Park E, Eck MJ, Thomä NH SPLINTS: small-molecule protein ligand interface stabilizers Curr Opin Struct Biol. 2016 Jan; 37:115-122

Karunakaran S, Chowdhury A, Donato F, Quairiaux C, Michel CM, Caroni P PV plasticity sustained through D1/5 dopamine signaling required for long-term memory consolidation Nat Neurosci. 2016 Jan; [Epub ahead of print]

Poli J, Gerhold CB, Tosi A, Hustedt N, Seeber A, Sack R, Herzog F, Pasero P, Shimada K, Hopfner KP, Gasser SM Mec1, INO80, and the PAF1 complex cooperate to limit transcription replication conflicts through RNAPII removal during replication stress Genes Dev. 2016 Jan; [Epub ahead of print]

Harr JC, Gonzalez-Sandoval A, Gasser SM Histones and histone modifications in perinuclear chromatin anchoring: from yeast to man EMBO Rep. 2016 Jan; [Epub ahead of print]

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