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Aug 28, 2014

New functions for chromatin remodelers

Large molecular motors consisting of up to a dozen different proteins regulate access to the genome, which is essential for the transcription of genes and for the repair of DNA damage. Susan Gasser and her team now reveal a new twist in the activity of such remodelers in the nucleus. In a recent paper in Molecular Cell they show that two related chromatin remodelers help transport broken DNA strands to specific sites in the nucleus for repair. Given the loss of genomic integrity that accompanies cancer and aging, it is not surprising to find that related remodelers are mutated early in the progression of human cancer. Read more

Aug 14, 2014

Crystal structure of COP9 signalosome elucidated

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Jul 29, 2014

Nancy Hynes elected President of the Scientific Board of the Swiss Cancer League

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Jul 17, 2014

Mechanism of action of thalidomide elucidated

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Next seminars & events

Sep 02, 2014. Time: 12.30  FMI Room 530  Add to my calendar  Register for this event

Basel Breast Consortium Tandem Seminar Serie
1. How pregnancy at early age protects against breast cancer
2. Immunotherapy for breast cancer: current state and future impact

1. Fabienne Meier-Abt, University Hospital Basel
2. Savas Soysal, University Hospital Basel
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Sep 04, 2014. Time: 11.00  FMI Room 530  Add to my calendar  Register for this event

Molecular links between nutrition, reproduction and fat metabolism in Caenorhabditis elegans
Hugo Aguilaniu, ENS Ecole Normale Supérieure de Lyon, France

Sep 08, 2014. Time: 16:00  FMI Room 530  Add to my calendar  Register for this event

Probing stem cell transcription mechanisms by single-cell single-molecule biochemistry
Robert Tjian, University of California, Berkeley, CA, USA
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Sep 11, 2014. Time: 11.30  FMI Room 530  Add to my calendar  Register for this event

Generating and selecting action repertoire
Rui Costa, Champalimaud Center for the Unknown, Lisbon, Portugal

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Recent Publications

Horigome C, Oma Y, Konishi T, Schmid R, Marcomini I, Hauer MH, Dion V, Harata M, Gasser SM SWR1 and INO80 Chromatin Remodelers Contribute to DNA Double-Strand Break Perinuclear Anchorage Site Choice Mol Cell. 2014 Aug; 55(4):626-39

Jermann P, Hoerner L, Burger L, Schübeler D Short sequences can efficiently recruit histone H3 lysine 27 trimethylation in the absence of enhancer activity and DNA methylation Proc Natl Acad Sci U S A. 2014 Aug; 111(33):E3415-21

Lingaraju GM, Bunker RD, Cavadini S, Hess D, Hassiepen U, Renatus M, Fischer ES, Thomä NH Crystal structure of the human COP9 signalosome Nature. 2014 Aug; 512(7513):161-5

Fischer ES, Böhm K, Lydeard JR, Yang H, Stadler MB, Cavadini S, Nagel J, Serluca F, Acker V, Lingaraju GM, Tichkule RB, Schebesta M, Forrester WC, Schirle M, Hassiepen U, Ottl J, Hild M, Beckwith RE, Harper JW, Jenkins JL, Thomä NH Structure of the DDB1-CRBN E3 ubiquitin ligase in complex with thalidomide Nature. 2014 Aug; 512(7512):49-53

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