Postdoctoral Positions: Oscillatory gene expression dynamics in developmental time control

Three postdoctoral positions are available in the group of Helge Grosshans to study the system-level properties, molecular mechanisms, and physiological outputs of developmental clocks.

We recently found that thousands of genes (~20% of the transcriptome) exhibit high-amplitude oscillatory expression in Caenorhabditis elegans that occur in synchrony with the developmental progression of worms through larval stages (Hendriks et al., Mol Cell 2014). With funding from an ERC Advanced Grant, we aim to identify and understand the molecular clocks that control transcriptional oscillations and developmental progression.

Successful candidates will apply high-throughput, single animal-based approaches to track developmental progression and generate quantitative models of biological clocks. We are looking for highly motivated individuals that enjoy challenging projects and opportunities to innovate. Excellent communication and organization skills, and the ability to work as a team member are equally important. Expertise with any or several of the following will be considered a plus: analysis of large sequencing, proteomics, and/or imaging datasets; modelling of biological systems; C. elegans work. A very competitive salary and access to state-of-the-art research facilities will be provided.

Our laboratory is located at the Friedrich Miescher Institute for Biomedical Research (FMI). The FMI, affiliated with the University of Basel and the Novartis Institutes for BioMedical Research, is an international institute aimed at understanding the basic molecular mechanisms of health and disease. It is situated in Basel, Switzerland, a city in the center of Europe offering an outstanding scientific and cultural environment.

Applications should be submitted electronically to

and include a motivation letter, CV and names and email addresses of referees.

For further information, please contact Helge Grosshans,

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