During my time as research group leader in Neurobiology at the Friedrich Miescher Institute my laboratory investigated the molecular mechanisms underlying synaptic plasticity in neuronal circuits of the brain.
We concentrated on understanding the dynamic activity of cytoskeletal filaments, primarily actin-based microfilaments and tubulin-based microtubules. This led us to the discovery that dendritic spines, tiny protrusions that form the contact sites for some 90% of brain synapses, are the primary sites of plasticity. For selected references and downloads describing this work follow the link to Publications.
As a member of the Institute's emeritus community I continue to enjoy the FMI's unique, multi-national environment and excellent science through our active seminar program and continued contact with younger colleagues.
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