Andrew Matus

In April 2007 I retired after 28 years as research group leader in Neurobiology at the Friedrich Miescher Institute. During that time the laboratory investigated the molecular mechanisms underlying synaptic plasticity in neuronal circuits of the brain.

We concentrated on understanding the dynamic activity of cytoskeletal filaments, primarily actin-based microfilaments and tubulin-based microtubules. This led us to discover that dendritic spines, tiny protrusions that form the contact sites for some 90% of brain synapses, are the primary sites of plasticity. For selected references and downloads describing this work follow the link to Publications.

As a member of the Institute's small emeritus community I continue to enjoy the FMI's unique, multi-national environment and excellent science through our active seminar program and continued contact with younger colleagues. For more information follow the other links.