Rainer W. Friedrich

Neuronal circuits and computations

The brain has evolved sophisticated strategies to extract, store and utilize information about its environment. Many of these computations result from neuronal interactions within complex circuits. We are using the olfactory system of zebrafish and mice as a model to study the function and development of neuronal circuits under intact and pathophysiological conditions.

Neuronal activity is monitored in vivo by electrophysiological recordings, voltage-sensitive dye imaging, and 2-photon calcium imaging of activity patterns across thousands of individual neurons. Transgenic and other approaches are used to identify and manipulate neurons with high precision. Experimental results are integrated into models to extract principal computational properties and developmental constraints of neuronal circuits.

Recent work analyzed the topology and dynamics of odor-evoked activity patterns at different stages of sensory processing and examined the emergence of circuit properties during development. The results provide insights into computations in the olfactory bulb and constitute the basis for future studies of neuronal circuits in the olfactory bulb and higher brain areas.

Additional information
FMI report pages for Rainer W. Friedrich

Rainer W. Friedrich
Gabi Gruber
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