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SELECTED PUBLICATIONS
Susan M. Gasser


Amitai, A., Seeber, A., Gasser, S.M.* and Holcman, D. (2017) Visualization of chromatin decompaction and break site extrusion as predicted by statistical polymer modeling of single locus trajectories.
Cell Reports, 18, 1200-1214
* Lead author

Hauer, M.H., Seeber, A., Singh, V., Thierry, R., Sack, R., Amitai, A., Kryzhanovska, M., Eglinger, J., Holcman, D., Owen-Hughes, T. and Gasser, S.M (2017) Histone degradation in response to DNA damage enhances chromatin dynamics and recombination rates.
Nature Struct. Mol. Biology, doi: 10.1038/nsmb.3347

Seeber, A., Hegnauer, A.M., Hustedt, N., Deshpande, I., Poli, J., Eglinger, J., Pasero, P., Gut, H., Shinohara, M., Hopfner, K-P., Shimada, K. and Gasser, S.M. (2016) RPA-mediated recruitment of MRX to forks and double-strand breaks holds sister chromatids together.
Molecular Cell, 64, 951 - 966. doi: 10.1016/j.molcel.2016.10.032

Zeller, P., Padeken, J., van Schendel, R., Kalck, V., Tijsterman, M. and Gasser, S.M. (2016) Histone H3K9 methylation is dispensable for C. elegans development, but suppresses RNA-DNA hybrid-associated repeat instability.
Nature Genetics, 48, 1385 - 1395. doi: 10.1038/ng.3672

Horigome, C., Bustard, D., Marcomini, I., Tsai-Pflugfelder, M., Cobb, J.A. and Gasser, S.M. (2016) PolySUMOylation by Siz2 and Mms21 triggers relocation of DNA breaks to nuclear pores through the Slx5/Slx8 STUbL.
Genes & Dev. 30, 931-945

Poli, J., Gerhold, C.-B., Tosi, A., Hustedt, N., Seeber, A., Sack, R., Herzog, F., Pasero, P., Shimada, K., Hopfner, K-P. and Gasser, S.M. (2016) Mec1, INO80 and the PAF1 complex cooperate to limit transcription-replication conflicts through RNAPII removal during replication stress.
Genes & Dev. 30, 337-354

Iwasaki, D., Hayashihara, K., Shima, H., Higashide, M., Terasawa, M., Gasser, S.M. and Shinohara, M. (2016) The MRX Complex Ensures NHEJ Fidelity through Multiple Pathways Including Xrs2-FHA-Dependent Tel1 Activation.
PLoS Genet. 12(3):e1005942

Gonzalez-Sandoval, A., Towbin, B.D., Kalck, V., Cabianca, D.S., Gaidatzis, D.,Hauer, M.H., Geng, L., Wang, L., Yang, T., Wang,. X., Zhao, K. and Gasser, S.M. (2015) Perinuclear Anchoring of H3K9-Methylated Chromatin Stabilizes Induced Cell Fate in C. elegans embryos..
Cell, 163, 1333-1347

Su XA, Dion V, Gasser SM, Freudenreich CH (2015) Regulation of recombination at yeast nuclear pores controls repair and triplet repeat stability.
Genes Dev. 29:1006-17

Padeken J, Zeller P, Gasser SM (2015) Repeat DNA in genome organization and stability.
Curr Opin Genet Dev. 31:12-9

Hustedt H, Seeber A, Sack R, Bhupinder B, Vlaming H, van Leeuwen F, Guenole A, van Attikum H, Srivas R, Ideker T, Shimada K, Gasser SM (2015) Yeast PP4 interacts with ATR homologue Ddc2-Mec1 and regulates checkpoint signaling.
Mol Cell. 55:273-289

Gerhold CB, Hauer MH, Gasser SM (2014) SWR1 and INO80 remodelers: Guardians of the genome.
J Mol Biol. 427:637-651

Gerhold CB, Gasser SM (2014) INO80 and SWR complexes: relating structure to function in chromatin remodeling.
Trends Cell Biol. 24:619-631

Horigome C, Oma Y, Konishi T, Schmid R, Marcomini I, Hauer MH, Dion V, Harata M, Gasser SM (2014) SWR1 and INO80 chromatin remodelers contribute to DNA double-strand break perinuclear anchorage site choice.
Mol Cell. 55:626-639

Weisman R, Cohen A, Gasser SM (2014) TORC2 - a new player in genome stability.
EMBO Mol Med. 6:995-1002

Seeber A, Dion V, Gasser SM (2014) Remodelers move chromatin in response to DNA damage.
Cell Cycle. 13:877-878

Shimada K, Fillipuzzi I, Stahl M, Helliwell S, Seeber A, Loewith R, Movva R, Gasser SM (2013) TORC2 signaling pathway guarantees genome stability in face of DNA strand breaks.
Mol Cell. 51:829-839

Ferreira HC, Towbin BD, Jegou T, Gasser SM (2013) The shelterin protein POT-1 anchors C. elegans telomeres through SUN-1 at the nuclear periphery.
J Cell Biol. 203:727-35

Seeber A, Dion V, Gasser SM (2013) Checkpoint kinases and nucleosome remodelers enhance global chromatin mobility in response to DNA damage.
Genes Dev. 27:1999-2008

Dion V, Kalck V, Seeber A, Schleker T, Gasser SM (2013) Cohesin and the nucleolus constrain the mobility of spontaneous repair foci.
EMBO Rep. 14:984-991

Kueng S, Oppikofer M, Gasser SM (2013) SIR proteins and the assembly of silent chromatin in budding yeast.
Annu Rev Genet. 47:275-306

Oppikofer M, Kueng S, Keusch JJ, Hassler M, Ladurner A, Gut H, Gasser SM (2013) Dimerization of Sir3 via its C-terminal winged helix domain is essential for yeast heterochromatin formation.
EMBO J. 32:437-449

Rohner S, Kalck V, Wang FF, Ikegami K, Lieb JD, Gasser SM*, Meister P (2013) Promoter- and RNA polymerase II-dependent hsp-16 gene association with nuclear pores in Caenorhabditis elegans.
J Cell Biol. 200:589-604
*SMG is corresponding author.

Towbin BD, Gonzalez-Aguilera C, Sack R, Gaidatzis D, Kalck V, Meister P, Askjaer P, Gasser SM (2012) Step-wise methylation of histone H3K9 positions chromosome arms at the nuclear periphery in C. elegans embryos.
Cell. 150:934-947

Dion V, Kalck V, Horigome C, Towbin BD, Gasser SM (2012) Increased dynamics of double strand breaks requires Mec1, Rad9 and the homologous recombination machinery.
Nat Cell Biol. 14:502-509

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