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Publications
Selected Original Papers
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Su XA, Dion V, Gasser SM, Freudenreich CH (2015)  Regulation of recombination at yeast nuclear pores controls repair and triplet repeat stability.
Genes Dev. 2015 May 4.
Horigome C, Dion V, Seeber A, Gehlen LR, Gasser SM (2015)  Visualizing the spatiotemporal dynamics of DNA damage in budding yeast.
Methods Mol Biol. 2015;1292:77-96. doi: 10.1007/978-1-4939-2522-3_6.
Hustedt N, Seeber A, Sack R, Tsai-Pflugfelder M, Bhullar B, Vlaming H, van Leeuwen F, Guenole A, van Attikum H, Srivas R, Ideker T, Shimada K, Gasser SM (2015)  Yeast PP4 interacts with ATR homolog Ddc2-Mec1 and regulates checkpoint signaling.
Mol Cell. 2015 Jan 22;57(2):273-89. doi: 10.1016/j.molcel.2014.11.016. Epub 2014 Dec 18.
Horigome C, Oma Y, Konishi T, Schmid R, Marcomini I, Hauer MH, Dion V, Harata M, Gasser SM (2014)  SWR1 and INO80 chromatin remodelers contribute to DNA double-strand break perinuclear anchorage site choice.
Mol Cell. 2014 Aug 21;55(4):626-39. doi: 10.1016/j.molcel.2014.06.027. Epub 2014 Jul 24.
Ferreira HC, Towbin BD, Jegou T, Gasser SM (2013)  The shelterin protein POT-1 anchors Caenorhabditis elegans telomeres through SUN-1 at the nuclear periphery.
J Cell Biol. 2013 Dec 9;203(5):727-35. doi: 10.1083/jcb.201307181. Epub 2013 Dec 2.
Dion V, Kalck V, Seeber A, Schleker T, Gasser SM (2013)  Cohesin and the nucleolus constrain the mobility of spontaneous repair foci.
EMBO Rep. 2013 Nov;14(11):984-91. doi: 10.1038/embor.2013.142. Epub 2013 Sep 10.
Nielsen I, Bentsen IB, Andersen AH, Gasser SM, Bjergbaek L (2013)  A Rad53 independent function of Rad9 becomes crucial for genome maintenance in the absence of the Recq helicase Sgs1.
PLoS One. 2013 Nov 20;8(11):e81015. doi: 10.1371/journal.pone.0081015. eCollection 2013.
Shimada K, Filipuzzi I, Stahl M, Helliwell SB, Studer C, Hoepfner D, Seeber A, Loewith R, Movva NR, Gasser SM (2013)  TORC2 signaling pathway guarantees genome stability in the face of DNA strand breaks.
Mol Cell. 2013 Sep 26;51(6):829-39. doi: 10.1016/j.molcel.2013.08.019. Epub 2013 Sep 12.
Seeber A, Dion V, Gasser SM (2013)  Checkpoint kinases and the INO80 nucleosome remodeling complex enhance global chromatin mobility in response to DNA damage.
Genes Dev. 2013 Sep 15;27(18):1999-2008. doi: 10.1101/gad.222992.113. Epub 2013 Sep 12.
Hustedt N, Gasser SM, Shimada K (2013)  Replication checkpoint: tuning and coordination of replication forks in s phase.
Genes (Basel). 2013 Aug 19;4(3):388-434. doi: 10.3390/genes4030388.
Rohner S, Kalck V, Wang X, Ikegami K, Lieb JD, Gasser SM, Meister P. (2013)  Promoter- and RNA polymerase II-dependent hsp-16 gene association with nuclear pores in Caenorhabditis elegans.
J Cell Biol. 2013 Mar 4;200(5):589-604. doi: 10.1083/jcb.201207024.
Oppikofer M, Kueng S, Keusch JJ, Hassler M, Ladurner AG, Gut H, Gasser SM (2013)  Dimerization of Sir3 via its C-terminal winged helix domain is essential for yeast heterochromatin formation.
EMBO J. 2013 Feb 6;32(3):437-49. doi: 10.1038/emboj.2012.343. Epub 2013 Jan 8.
Hegnauer AM, Hustedt N, Shimada K, Pike BL, Vogel M, Amsler P, Rubin SM, van Leeuwen F, Guenole A, van Attikum H, Thoma NH, Gasser SM (2012)  An N-terminal acidic region of Sgs1 interacts with Rpa70 and recruits Rad53 kinase to stalled forks.
EMBO J. 2012 Sep 12;31(18):3768-83. doi: 10.1038/emboj.2012.195. Epub 2012 Jul 20.
Towbin BD, Gonzalez-Aguilera C, Sack R, Gaidatzis D, Kalck V, Meister P, Askjaer P, Gasser SM (2012)  Step-wise methylation of histone H3K9 positions heterochromatin at the nuclear periphery.
Cell. 2012 Aug 31;150(5):934-47. doi: 10.1016/j.cell.2012.06.051.
Dion V, Kalck V, Horigome C, Towbin BD and Gasser SM (2012)  Increased mobility of double-strand breaks requires Mec1, Rad9 and the homologous recombination machinery.
Nature Cell Biol. 012 Apr 8. doi: 10.1038/ncb2465
Neumann FR, Dion V, Gehlen L, Tsai-Pflugfelder M, Schmid R, Taddei A and Gasser SM (2012)  Targeted INO80 enhances subnuclear chromatin movement and ectopic homologous recombination.
Genes Dev. 2012 Feb 15;26(4):369-83. doi: 10.1101/gad.176156.111.
Kueng S, Tsai-Pflugfelder M, Oppikofer M, Ferreira HC, Roberts E, Tsai C, Roloff TC, Sack R, Gasser SM (2012)  Regulating repression: roles for the sir4 N-terminus in linker DNA protection and stabilization of epigenetic states.
PLoS Genet. 2012; 8(5):e1002727. doi: 10.1371/journal.pgen.1002727. Epub 2012 May 24.
Meister P, Schott S, Xiao Y, Rohner S, Bedet C, Bodennec S, Hudry B, Molin L, Solari F, Gasser, SM, Palladino F (2011)  Caenorhabditis elegans Heterochromatin protein 1 (HPL-2) links developmental plasticity, longevity and lipid metabolism.
Genome Biol. 2011 Dec 20;12(12):R123. doi: 10.1186/gb-2011-12-12-r123.
Mattout A, Pike BL, Towbin BD, Bank EM, Gonzalez-Sandoval A, Stadler MB, Meister P, Gruenbaum Y, Gasser SM (2011)  An EDMD mutation in C. elegans lamin blocks muscle-specific gene relocation and compromises muscle integrity.
Curr Biol. 2011 Oct 11;21(19):1603-14. doi: 10.1016/j.cub.2011.08.030. Epub 2011 Sep 29.
Ehrentraut S, Hassler M, Oppikofer M, Kueng S, Weber JM, Mueller JW, Gasser SM, Ladurner AG, Ehrenhofer-Murray AE (2011)  Structural basis for the role of the Sir3 AAA+ domain in silencing: interaction with Sir4 and unmethylated histone H3K79.
Genes Dev. 2011 Sep 1;25(17):1835-46. doi: 10.1101/gad.17175111.
Horigome C, Okada T, Shimazu K, Gasser SM, Mizuta K (2011)  Ribosome biogenesis factors bind a nuclear envelope SUN domain protein to cluster yeast telomeres.
EMBO J. 2011 Aug 5;30(18):3799-811. doi: 10.1038/emboj.2011.267.
Ferreira HC, Luke B, Schober H, Kalck V, Lingner J, Gasser SM (2011)  The PIAS homologue Siz2 regulates perinuclear telomere position and telomerase activity in budding yeast.
Nat Cell Biol. 2011 Jun 12;13(7):867-74.doi: 10.1038/ncb2263.
Oppikofer M, Kueng S, Martino F, Soeroes S, Hancock SM, Chin JW, Fischle W, Gasser SM (2011)  A dual role of H4K16 acetylation in the establishment of yeast silent chromatin.
EMBO J. 2011 Jun 10;30(13):2610-21. doi: 10.1038/emboj.2011.170.
Stulemeijer IJE, Pike BL, Faber AW, Verzijlbergen KF, van Welsem T, Frederiks F, Lenstra TL, Holstenge FCP, Gasser SM, van Leeuwen F (2011)  Dot1 binding induces chromatin re-arrangements by histone methylation-dependent and -independent mechanisms.
Epigenetics Chromatin. 2011 Feb 3;4(1):2. doi: 10.1186/1756-8935-4-2.
Towbin, BD, Meister, P, Pike, BL and Gasser, SM (2011)  Repetitive trans-genes in C. elegans accumulate heterochromatic marks and are sequestered at the nuclear envelope in a copy number- and lamin-dependent manner.
Cold Spring Harb Symp Quant Biol. 2010;75:555-65. doi: 10.1101/sqb.2010.75.041. Epub 2011 Apr 5.
Kitada T, Schleker T, Sperling AS, Xie W, Gasser SM, Grunstein M (2011)  yH2A is a component of yeast heterochromatin required for telomere elongation.
Cell Cycle. 2011 Jan 15;10(2):293-300. Epub 2011 Jan 15.
Gehlen L, Nagai S, Shimada K, Meister P, Taddei A, Gasser SM (2011)  Nuclear geometry and rapid mitosis ensure asymmetric episome segregation in yeast.
Curr Biol. 2011 Jan 11;21(1):25-33. doi: 10.1016/j.cub.2010.12.016. Epub 2010 Dec 30.
Gasser SM, Li E; eds (2011)  Epigenetics and disease: pharmaceutical opportunities. Preface.
Prog Drug Res. 2011;67:v-viii
Gehlen L, Gasser SM (corresponding author),Dion V (2011)  How broken DNA finds its template for repair: a computational approach
Prog Theoretical Physics Suppl.2011; 191, 20 - 29.
Yoshida T, Shimada K, Oma Y, Kalck V, Akimura K, Taddei A, Iwahashi H, Kugou K, Ohta K, Gasser SM, Harata M (2010)  Actin-related protein Arp6 influences H2A.Z-dependent and -independent gene expression and links ribosomal protein genes to nuclear pores.
PLoS Genet. 2010 Apr 15;6:e1000910.
Varela E, Schlecht U, Moina A, Fackenthal JD, Washburn BK, Niederhauser-Widerkehr C, Tsai-Pflugfelder M, Primig M, Gasser SM, Esposito RE (2010)  Mitotic Expression of Spo13 Alters M-phase Progression and Nucleolar Localization of Cdc14 in Budding Yeast.
Genetics. 2010 Jul;185(3):841-54. doi: 10.1534/genetics.109.113746. Epub 2010 Apr 20.
Yoshida T, Shimada K, Oma Y, Kalck V, Akimura K, Taddei A, Iwahashi H, Kugou K, Ohta K, Gasser SM, Harata M (2010)  Actin-related protein Arp6 influences H2A.Z-dependent and -independent gene expression and links ribosomal protein genes to nuclear pores.
PLoS Genet. 2010 Apr 15;6(4):e1000910. doi: 10.1371/journal.pgen.1000910.
Meister P, Towbin BD, Pike BL, Ponti A, Gasser SM (2010)  The spatial dynamics of tissue-specific promoters during C. elegans development.
Genes Dev. 2010 Apr 15;24(8):766-82. doi: 10.1101/gad.559610.
Ebrahimi H, Robertson ED, Taddei A, Gasser SM, Donaldson AD, Hiraga S (2010)  Early initiation of a replication origin tethered at the nuclear periphery.
J Cell Sci. 2010 Apr 1;123(Pt 7):1015-9. doi: 10.1242/jcs.060392. Epub 2010 Mar 2.
Schleker T, Shimada K, Sack R, Pike BL, Gasser SM (2010)  Cell cycle-dependent phosphorylation of Rad53 kinase by Cdc5 and Cdc28 modulates checkpoint adaptation.
Cell Cycle. 2010 Jan 15;9(2):350-63. Epub 2010 Jan 27.
Meister P, Gehlen LR, Varela E, Kalck V, Gasser SM (2010)  Visualizing yeast chromosomes and nuclear architecture.
Methods Enzymol. 2010;470:535-67. doi: 10.1016/S0076-6879(10)70021-5. Epub 2010 Mar 1.
Towbin BD, Meister P, Pike BL, Gasser SM (2010)  Repetitive Transgenes in C. elegans accumulate heterochromatic marks and are sequestered at the nuclear envelope in a copy-number- and lamin-dependent manner.
Cold Spring Harb Symp Quant Biol. 2010;75:555-65.
Schober H, Ferreira H, Kalck V, Gehlen LR, Gasser SM (2009)  Yeast telomerase and the SUN domain protein Mps3 anchor telomeres and repress subtelomeric recombination.
Genes Dev. 2009 Apr 15;23:928-38.
Varela E, Shimada K, Laroche T, Leroy D, Gasser SM (2009)  Lte1, Cdc14 and MEN-controlled Cdk inactivation in yeast coordinate rDNA decompaction with late telophase progression.
EMBO J. 2009 Jun 3;28(11):1562-75. doi: 10.1038/emboj.2009.111. Epub 2009 Apr 23.
Martino F, Kueng S, Robinson P, Tsai-Pflugfelder M, van Leeuwen F, Ziegler M, Cubizolles F, Cockell MM, Rhodes D, Gasser SM (2009)  Reconstitution of yeast silent chromatin: multiple contact sites and O-AADPR binding load SIR complexes onto nucleosomes in vitro.
Mol Cell. 2009 Feb 13;33(3):323-34. doi: 10.1016/j.molcel.2009.01.009.
Taddei A, Van Houwe G, Nagai S, Erb I, van Nimwegen E, Gasser SM (2009)  The functional importance of telomere clustering: global changes in gene expression result from SIR factor dispersion.
Genome Res. 2009 Apr;19(4):611-25. doi: 10.1101/gr.083881.108. Epub 2009 Jan 29.
Bystricky K, Van Attikum H, Montiel MD, Dion V, Gehlen L, Gasser SM (2009)  Regulation of nuclear positioning and dynamics of the silent mating type loci by the yeast Ku70/Ku80 complex.
Mol Cell Biol. 2009 Feb;29(3):835-48. doi: 10.1128/MCB.01009-08. Epub 2008 Dec 1.
Nagai S, Dubrana K, Tsai-Pflugfelder M, Davidson MB, Roberts TM, Brown GW, Varela E, Hediger F, Gasser SM, Krogan N (2008)  Functional targeting of DNA damage to a nuclear pore-associated SUMO-dependent ubiquitin ligase.
Science. 2008 Oct 24;322(5901):597-602. doi: 10.1126/science.1162790.
Shimada K, Oma Y, Schleker T, Kugou K, Ohta K, Harata M, Gasser SM (2008)  Ino80 chromatin remodeling complex promotes recovery of stalled replication forks.
Curr Biol. 2008 Apr 22;18(8):566-75. doi: 10.1016/j.cub.2008.03.049. Epub 2008 Apr 10.
Rohner S, Gasser SM, Meister P (2008)  Modules for cloning-free chromatin tagging in Saccharomyces cerevisae.
Yeast. 2008 Mar;25(3):235-9. doi: 10.1002/yea.1580.
Schober H, Kalck V, Vega-Palas MA, Van Houwe G, Sage D, Unser M, Gartenberg MR, Gasser SM (2008)  Controlled exchange of chromosomal arms reveals principles driving telomere interactions in yeast.
Genome Res. 2008 Feb;18(2):261-71. Epub 2007 Dec 20.
Dubrana K, van Attikum H, Hediger F, Gasser SM (2007)  The processing of double-strand breaks and binding of single-strand-binding proteins RPA and Rad51 modulate the formation of ATR-kinase foci in yeast.
J Cell Sci. 2007 Dec 1;120(Pt 23):4209-20. Epub 2007 Nov 14.
Sexton T, Schober H, Fraser P, Gasser SM (2007)  Gene regulation through nuclear organization.
Nat Struct Mol Biol. 2007 Nov;14(11):1049-55. Epub 2007 Nov 5.
Van Attikum H, Fritsch O, Gasser SM (2007)  Distinct roles for SWR1 and INO80 chromatin remodeling complexes at chromosomal double-strand breaks.
EMBO J. 2007 Sep 19;26(18):4113-25. Epub 2007 Aug 30.
Meister P, Taddei A, Ponti A, Baldacci G, Gasser SM (2007)  Replication foci dynamics: replication patterns are modulated by S-phase checkpoint kinases in fission yeast.
EMBO J. 2007 Mar 7;26(5):1315-26. Epub 2007 Feb 15.
Shimada K, Gasser SM (2007)  The origin recognition complex functions in sister-chromatid cohesion in Saccharomyces cerevisiae.
Cell. 2007 Jan 12;128(1):85-99.
Taddei A, Van Houwe G, Hediger F, Kalck V, Cubizolles F, Schober H, Gasser SM (2006)  Nuclear pore association confers optimal expression levels for an inducible yeast gene.
Nature. 2006 Jun 8;441(7094):774-8.
Gehlen LR, Rosa A, Klenin K, Langowski J, Gasser SM, and Bystricky K (2006)  Spatially confined polymer chains: implication of chromatin fiber flexibility and peripheral anchoring on telomere-telomere interaction.
J. of Physics: Condens. Matter 2006 Apr 12;18(14); S245 doi:10.1088/0953-8984/18/14/S09
Cubizolles F, Martino F, Perrod S and Gasser SM (2006)  A homotrimer-heterotrimer switch in Sir2 structure differentiates rDNA and telomeric silencing.
Mol Cell. 2006 Mar 17;21(6):825-36.
Hediger F, Berthiau AS, Van Houwe G, Gilson E and Gasser SM (2006)  Subtelomeric Factors Antagonize Telomere Anchoring and Tel1-independent Telomere Length Regulation.
EMBO J. 2006 Feb 22;25(4):857-67. Epub 2006 Feb 9.
Rosa A, Maddocks JH, Neumann FR, Gasser SM, Stasiak A (2006)  Measuring limits of telomere movement on nuclear envelope.
Biophys J. 2006 Feb 1;90(3):L24-6. Epub 2005 Dec 9.
Cobb JA, Schleker T, Rojas V, Bjergbaek L, Tercero JA, Gasser SM (2005)  Replisome instability, fork collapse, and gross chromosomal rearrangements arise synergistically from Mec1 kinase and RecQ helicase mutations.
Genes Dev. 2005 Dec 15;19(24):3055-69.
Sage D, Neumann FR, Hediger F, Gasser SM, Unser M (2005)  Automatic tracking of individual fluorescence particles -Application to the study of chromosome dynamics.
IEEE Trans Image Process. 2005 Sep;14(9):1372-83.
Meister P, Taddei A, Vernis L, Poidevin M, Gasser SM, Baldacci G (2005)  Temporal separation of replication and recombination requires the intra-S checkpoint.
J Cell Biol. 2005 Feb 14;168(4):537-44.
Rosa A, Maddocks JH, Neumann FR, Gasser SM, Stasiak A (2005)  Measuring limits of telomere movement on nuclear envelopes.
Biophys J. 2006 Feb 1;90(3):L24-6. Epub 2005 Dec 9.
Bystricky K, Laroche T, van Houwe G, Blaszczyk M, Gasser SM (2005)  Chromosome looping in yeast: telomere pairing and coordinated movement reflect anchoring efficiency and territorial organization.
J Cell Biol. 2005 Jan 31;168(3):375-87.
Bjergbaek L, Cobb JA, Tsai-Pflugfelder M, Gasser SM (2005)  Mechanistically Distinct roles for the RecQ helicase Sgs1p at stalled replication forks.
EMBO J. 2005 Jan 26;24(2):405-17. Epub 2004 Dec 23.
Taddei A, Hediger F, Neumann FR, Bauer C, Gasser SM (2004)  Separation of silencing from perinuclear anchoring functions in yeast Ku80, Sir4 and Esc1 proteins
EMBO J. 2004 Mar 24;23(6):1301-12. Epub 2004 Mar 11.
Bystricky K, Heun P, Gehlen L, Langowski J, Gasser SM (2004)  Long-range compaction and flexibility of interphase chromatin in budding yeast analysed by high-resolution imaging techniques.
Proc Natl Acad Sci U S A. 2004 Nov 23;101(47):16495-500. Epub 2004 Nov 15.
Gartenberg MR, Neumann FR, Laroche T, Blaszczyk M, Gasser SM (2004)  Sir-mediated Repression Can Occur Independently of Chromosomal and Subnuclear Contexts
Cell. 2004 Dec 29;119(7):955-67.
Van Attikum H, Fritsch O, Hohn B, Gasser SM (2004)  Recruitment of the INO80 complex by H2A phosphorylation links ATP-dependent chromatin remodeling with DNA double-strand break repair.
Cell. 2004 Dec 17;119(6):777-88.
Hediger F, Taddei A, Neumann FR, Gasser SM (2004)  Methods for visualizing chromatin dynamics in living yeast.
Methods Enzymol. 2004;375:345-65. No abstract available.
Vilain N, Tsai-Pflugfelder M, Benoit A, Gasser SM, Leroy D (2003)  Modulation of drug sensitivity in yeast cells by the ATP-binding domain of human DNA topoisomerase IIalpha.
Nucleic Acids Res. 2003 Oct 1;31(19):5714-22.
Cobb JA, Bjergbaek L, Shimada K, Frei C, Gasser SM (2003)  DNA polymerase stabilization at stalled replication forks requires Mec1 and the RecQ helicase Sgs1.
EMBO J. 2003 Aug 15;22(16):4325-36.
Spector DL, Gasser SM (2003)  A molecular dissection of nuclear function. Conference on the dynamic nucleus: questions and implications.
EMBO Rep. 2003 Jan;4(1):18-23. No abstract available.
Shimada K, Pasero P, Gasser SM (2002)  ORC and the intra-S phase checkpoint: a threshold regulates Rad53p activation in S phase.
Genes Dev. 2002 Dec 15;16(24):3236-52.
Hediger F, Neumann FR, Van Houwe G, Dubrana K, Gasser SM (2002)  Live imaging of telomeres: yKu and Sir proteins define redundant telomere-anchoring pathways in yeast.
Curr Biol. 2002 Dec 23;12(24):2076-89.
Hediger F, Dubrana K, Gasser SM (2002)  Myosin-like proteins 1 and 2 are not required for silencing or telomere anchoring but act in the Tel1 pathway of telomere length control.
J Struct Biol. 2002 Oct-Dec;140(1-3):79-91.
Duncker B, Shimada K, Tsai-Pflugfelder M, Pasero P, Gasser SM (2002)  An N-terminal domain of Dbf4p mediates interaction with both ORC and Rad53p and can deregulate late origin firing.
Proc Natl Acad Sci U S A. 2002 Dec 10;99(25):16087-92. Epub 2002 Nov 19.
Teixeira MT, Forstemann K, Gasser SM, Lingner J (2002)  Intracellular trafficking of yeast telomerase components.
EMBO Rep. 2002 Jul;3(7):652-9.
Heun P, Laroche T, Shimada K, Furrer P, Gasser SM (2001)  Chromosomal dynamics in the yeast interphase nucleus.
Science. 2001 Dec 7;294(5549):2181-6.
Maillet L, Gaden F, Brevet V, Fourel G, Martin SG, Dubrana K, Gasser SM, Gilson E (2001)  Ku-deficient strains exhibit alternative states of silencing competence.
EMBO Rep. 2001 Mar;2(3):203-10.
Leroy D, Kajava AV, Frei C, Gasser SM (2001)  Analysis of etoposide binding to subdomains of human DNA topoisomerase II alpha in the absence of DNA.
J Cell Biol. 2001 Jan 22;152(2):385-400.
Heun P, Laroche T, Raghuraman MK, Gasser SM (2001)  The positioning and dynamics of origins of replication in the budding yeast nucleus. (see also In Brief and Commentary, same issue)
J Cell Biol. 2001 Jan 22;152(2):385-400.
Perrod S, Cockell MM, Laroche T, Renauld H, Ducrest A, Bonnard C, Gasser SM (2001)  A cytosolic NAD-dependent deacetylase, Hst2p, can modulate nucleolar and telomeric silencing in yeast.
EMBO J. 2001 Jan 15;20(1-2):197-209.
Ernst AI, Soltermann A, Sigrist JA, Widmer L, Gasser SM, Stahel RA (2000)  Ectopic expression of human topoisomerase IIalpha fragments and etoposide resistance in mammalian cells.
Int J Cancer. 2000 Oct 1;88(1):99-107.
Stone EM, Heun P, Laroche T, Pillus L, Gasser SM (2000)  MAP kinase signaling induces nuclear reorganization in budding yeast.
Curr Biol. 2000 Apr 6;10(7):373-82.
Laroche T, Martin SG, Tsai-Pflugfelder M, Gasser SM (2000)  The dynamics of yeast telomeres and silencing proteins through the cell cycle.
J Struct Biol. 2000 Apr;129(2-3):159-74.
Cockel M, Perrod S, Gasser SM (2000)  Analysis of Sir2p domains required for rDNA and telomeric silencing in Saccharomyces cerevisiae.
Genetics. 2000 Mar;154(3):1069-83. Erratum in: Genetics 2000 Aug;155(4):following 2020.
Frei C, Gasser SM (2000)  The yeast Sgs1 helicase acts upstream of Rad53p in the DNA replication checkpoint and colocalizes with Rad53p in S-phase specific foci.
Genes Dev. 2000 Jan 1;14(1):81-96.
Vassetzky NS, Gaden F, Brun C, Gasser SM, Gilson E (1999)  Taz1p and Teb1p, two telobox proteins in Schizosaccharomyces pombe, recognize different telomere-related DNA sequences.
Nucleic Acids Res. 1999 Dec 15;27(24):4687-94
Vasetskii NS, Gilson E, Gasser SM (1999)  Telomere-binding activity of Schizosaccharomyces pombe yeasts.
Mol Biol (Mosk). 1999 Jul-Aug;33(4):644-50. Russian. No abstract available.
Pasero, P, Duncker BP, Schwob E and Gasser SM (1999)  A role for the Cdc7 kinase regulatory subunit Dbf4p in the formation of initiation competent origins of replication.
Genes Dev. 1999 Aug 15;13(16):2159-76.
Pasero P, Duncker BP, Gasser SM (1999)  In vitro DNA replication in yeast nuclear extracts.
Methods. 1999 Jul;18(3):368-76, 323.
Duncker BP, Pasero P, Braguglia D, Heun P, Weinreich M, Gasser SM (1999)  Cyclin B/Cdk1 stimulates ORC- and Cdc6-independent steps of semiconservative plasmid replication in yeast nuclear extracts.
Mol Cell Biol. 1999 Feb;19(2):1226-41.
Martin SG, Laroche T, Suka N, Grunstein M, Gasser SM (1999)  Relocalization of telomeric Ku and SIR proteins in response to DNA strand breaks in yeast.
Cell. 1999 May 28;97(5):621-33.
Cockell M, Renauld H, Watt P, Gasser SM (1998)  Sif2p interacts with Sir4p N-terminal domain and antagonizes telomeric silencing in yeast.
Curr Biol. 1998 Jun 18;8(13):787-90.
Braguglia D, Heun P, Pasero P, Duncker B, Gasser SM (1998)  Semi-conservative replication in yeast nuclear extracts requires Dna2 helicase and supercoiled template.
J Mol Biol. 1998 Aug 28;281(4):631-49.
Gotta, M, Palladino, F and Gasser, SM (1998)  Functional characterization of the N terminus of Sir3p.
Mol Cell Biol. 1998 Oct;18(10):6110-20.
Laroche, T, Martin, SG, Gotta, M, Gorham, HC, Pryde, FE, Louis, EJ and Gasser, SM (1998)  Mutation of yeast Ku genes disrupts the subnuclear organization of telomeres.
Curr Biol. 1998 May 21;8(11):653-6.
Pasero P, Braguglia D, Gasser SM (1997)  ORC-dependent and Origin-specific initiation of DNA replication at defined foci in isolated yeast nuclei.
Genes Dev. 1997 Jun 15;11(12):1504-18.
Kennedy BK, Gotta M, Sinclair DA, Mills K, McNabb DS, Murthy M, Pak SM, Laroche T, Gasser SM, Guarente L (1997)  Redistribution of silencing proteins from telomeres to the nucleolus is associated with extension of life span in S. cerevisiae.
Cell. 1997 May 2;89(3):381-91.
Gotta, M, Strahl-Bolsinger, S, Renauld, H, Kennedy, BK, Laroche, T, Grunstein, M and Gasser, SM (1997)  Localization of Sir2p: the nucleolus as a compartment for Silent Information Regulators.
EMBO J. 1997 Jun 2;16(11):3243-55.
Maillet, L, Boscheron, C, Gotta, M, Marcand, S, Gilson, E and Gasser, SM (1996)  Evidence for silencing subcompartments within the yeast nucleus: a role for telomere proximity and Sir protein concentration in silencer-mediated repression
Genes Dev. 1996 Jul 15;10(14):1796-811.
Gotta, M, Laroche, T, Formenton, A, Maillet, L, Scherthan, H and Gasser, SM (1996)  The clustering of telomeres and colocalization with Rap1, Sir3 and Sir4 proteins in wild-type S. cerevisiae.
J Cell Biol. 1996 Sep;134(6):1349-63.
Cockell M, Palladino F, Laroche T, Kyrion G, Liu C, Lustig AJ, Gasser SM (1995)  The carboxy-termini of SIR4 and RAP1 affect SIR3 localization: Evidence for a multi-component complex required for yeast telomeric silencing.
J Cell Biol. 1995 May;129(4):909-24.
Hecht, A, Laroche, T, Strahl-Bolsinger, S, Gasser, SM, Grunstein, M (1995)  Histone H3 and H4 N-termini interact with SIR3 and SIR4 proteins: a molecular model for the formation heterochromatin in yeast.
Cell. 1995 Feb 24;80(4):583-92.
Gilson E, Mueller T, Sogo J, Laroche T, Gasser SM (1994)  RAP1 promotes single- to double-strand association of yeast telomeric DNA: implications for telomere-telomere interactions
Nucleic Acids Res. 1994 Dec 11;22(24):5310-20.
Vassetzky YS, Dang Q, Benedetti P, Gasser SM (1994)  Topoisomerase II forms multimer in vitro: effects of metals, b-glycerophosphate and phosphorylation of its C-terminal domain
Mol Cell Biol. 1994 Oct;14(10):6962-74.
Palladino F, Laroche T, Gilson E, Axelrod A, Pillus L, Gasser SM (1993)  SIR3 and SIR4 proteins are required for the positioning and integrity of yeast telomeres.
Cell. 1993 Nov 5;75(3):543-55.
Cardenas ME, Dang Q, Glover CVC, Gasser SM (1992)  Casein kinase II phosphorylates the eukaryote-specific C-terminus of topoisomerase II in vivo.
EMBO J. 1992 May;11(5):1785-96.
Klein, F, Laroche, T, Cardenas, ME, Hofmann, JFX, Schweizer, D and Gasser, SM (1992)  Localization of RAP1 and Topoisomerase II in Nuclei and Meiotic Chromosomes of Yeast
J Cell Biol. 1992 Jun;117(5):935-48.
Amati B, Pick L, Laroche T, Gasser SM (1990)  Nuclear scaffold attachment stimulates but is not necessary for ARS activity in S. cerevisiae: Analysis of the Drosophila ftz SAR.
EMBO J. 1990 Dec;9(12):4007-16.
Amati B, Gasser SM (1990)  Drosophila scaffold-attached regions bind near nuclear scaffolds and can function as ARS elements in both budding and fission yeasts.
Mol Cell Biol. 1990 Oct;10(10):5442-54.
Hofmann JFX, Laroche T, Brand AH Gasser SM (1989)  "RAP-1 is necessary for DNA loop formation in vitro at the silent mating type locus, HML."
Cell, 57, 725-737.