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Publications


Flury V, Georgescu PR, Iesmantavicius V, Shimada Y, Kuzdere T, Braun S, Bühler M The Histone Acetyltransferase Mst2 Protects Active Chromatin from Epigenetic Silencing by Acetylating the Ubiquitin Ligase Brl1 Mol Cell. 2017 Jul; 67(2):294-307

Hauer MH, Seeber A, Singh V, Thierry R, Sack R, Amitai A, Kryzhanovska M, Eglinger J, Holcman D, Owen-Hughes T, Gasser SM Histone degradation in response to DNA damage enhances chromatin dynamics and recombination rates Nat Struct Mol Biol. 2017 Feb; 24(2):99-107

Miyake Y, Keusch JJ, Wang L, Saito M, Hess D, Wang X, Melancon BJ, Helquist P, Gut H, Matthias P Structural insights into HDAC6 tubulin deacetylation and its selective inhibition Nat Chem Biol. 2016 Sep; 12(9):748-754

Grzmil M, Seebacher J, Hess D, Behe M, Schibli R, Moncayo G, Frank S, Hemmings BA Inhibition of MNK pathways enhances cancer cell response to chemotherapy with temozolomide and targeted radionuclide therapy Cell Signal. 2016 Jun; 28(9):1412-1421

Poli J, Gerhold CB, Tosi A, Hustedt N, Seeber A, Sack R, Herzog F, Pasero P, Shimada K, Hopfner KP, Gasser SM Mec1, INO80, and the PAF1 complex cooperate to limit transcription replication conflicts through RNAPII removal during replication stress Genes Dev. 2016 Feb; 30(3):337-54

Rüegger S, Miki TS, Hess D, Großhans H The ribonucleotidyl transferase USIP-1 acts with SART3 to promote U6 snRNA recycling Nucleic Acids Res. 2015 Mar; 43(6):3344-57

Zhang L, Tang F, Terracciano L, Hynx D, Kohler R, Bichet S, Hess D, Cron P, Hemmings BA, Hergovich A, Schmitz-Rohmer D NDR Functions as a Physiological YAP1 Kinase in the Intestinal Epithelium Curr Biol. 2015 Feb; 25(3):296-305

Hustedt N, Seeber A, Sack R, Tsai-Pflugfelder M, Bhullar B, Vlaming H, van Leeuwen F, Guénolé A, van Attikum H, Srivas R, Ideker T, Shimada K, Gasser SM Yeast PP4 Interacts with ATR Homolog Ddc2-Mec1 and Regulates Checkpoint Signaling Mol Cell. 2015 Jan; 57(2):273-89

Arnold A, Rahman MM, Lee MC, Muehlhaeusser S, Katic I, Gaidatzis D, Hess D, Scheckel C, Wright JE, Stetak A, Boag PR, Ciosk R Functional characterization of C. elegans Y-box-binding proteins reveals tissue-specific functions and a critical role in the formation of polysomes Nucleic Acids Res. 2014 Dec; 42(21):13353-69

Lingaraju GM, Bunker RD, Cavadini S, Hess D, Hassiepen U, Renatus M, Fischer ES, Thomä NH Crystal structure of the human COP9 signalosome Nature. 2014 Aug; 512(7513):161-5

MacDonald G, Nalvarte I, Smirnova T, Vecchi M, Aceto N, Dolemeyer A, Frei A, Lienhard S, Wyckoff J, Hess D, Seebacher J, Keusch JJ, Gut H, Salaun D, Mazzarol G, Disalvatore D, Bentires-Alj M, Di Fiore PP, Badache A, Hynes NE Memo is a copper-dependent redox protein with an essential role in migration and metastasis Sci Signal. 2014 Jun; 7(329):ra56

Scharenberg MA, Pippenger BE, Sack R, Zingg D, Ferralli J, Schenk S, Martin I, Chiquet-Ehrismann R TGF--induced differentiation into myofibroblasts involves specific regulation of two MKL1 isoforms J Cell Sci. 2014 Mar; 127(Pt 5):1079-91

Grzmil M, Huber RM, Hess D, Frank S, Hynx D, Moncayo G, Klein D, Merlo A, Hemmings BA MNK1 pathway activity maintains protein synthesis in rapalog-treated gliomas J Clin Invest. 2014 Feb; 124(2):742-54

Loedige I, Gaidatzis D, Sack R, Meister G, Filipowicz W The mammalian TRIM-NHL protein TRIM71/LIN-41 is a repressor of mRNA function Nucleic Acids Res. 2013 Jan; 41(1):518-32

Chen CI, Keusch JJ, Klein D, Hess D, Hofsteenge J, Gut H Structure of human POFUT2: insights into thrombospondin type 1 repeat fold and O-fucosylation EMBO J. 2012 Sep; 31(14):3183-97

Towbin BD, González-Aguilera C, Sack R, Gaidatzis D, Kalck V, Meister P, Askjaer P, Gasser SM Step-Wise Methylation of Histone H3K9 Positions Heterochromatin at the Nuclear Periphery Cell. 2012 Aug; 150(5):934-947

Kueng S, Tsai-Pflugfelder M, Oppikofer M, Ferreira HC, Roberts E, Tsai C, Roloff TC, Sack R, Gasser SM Regulating repression: roles for the sir4 N-terminus in linker DNA protection and stabilization of epigenetic States PLoS Genet. 2012 May; 8(5):e1002727

Xue G, Restuccia DF, Lan Q, Hynx D, Dirnhofer S, Hess D, Rüegg C, Hemmings BA Akt/PKB-Mediated Phosphorylation of Twist1 Promotes Tumor Metastasis via Mediating Cross-Talk between PI3K/Akt and TGF- Signaling Axes Cancer Discovery. 2012 Mar; 2:248-259

Schmitges FW, Prusty AB, Faty M, Stützer A, Lingaraju GM, Aiwazian J, Sack R, Hess D, Li L, Zhou S, Bunker RD, Wirth U, Bouwmeester T, Bauer A, Ly-Hartig N, Zhao K, Chan H, Gu J, Gut H, Fischle W, Müller J, Thomä NH Histone Methylation by PRC2 Is Inhibited by Active Chromatin Marks Mol Cell. 2011 May 6;42(3):330-41.

Brellier F, Ruggiero S, Zwolanek D, Martina E, Hess D, Brown-Luedi M, Hartmann U, Koch M, Merlo A, Lino M, Chiquet-Ehrismann R SMOC1 is a tenascin-C interacting protein over-expressed in brain tumors Matrix Biol. 2011 Apr;30(3):225-33.

Vichalkovski A, Gresko E, Hess D, Restuccia DF, Hemmings BA PKB/AKT phosphorylation of the transcription factor Twist-1 at Ser42 inhibits p53 activity in response to DNA damage Oncogene. 2010 Jun 17;29(24):3554-65.

Keller C, Woolcock K, Hess D, Bühler M Proteomic and functional analysis of the noncanonical poly(A) polymerase Cid14 RNA. 2010 Jun;16(6):1124-9.

Heinrich C, Keller C, Boulay A, Vecchi M, Bianchi M, Sack R, Lienhard S, Duss S, Hofsteenge J, Hynes NE Copine-III interacts with ErbB2 and promotes tumor cell migration Oncogene. 2010 Mar 18;29(11):1598-610.

Schleker T, Shimada K, Sack R, Pike BL, Gasser SM Cell cycle-dependent phosphorylation of Rad53 kinase by Cdc5 and Cdc28 modulates checkpoint adaptation Cell Cycle. 2010 Jan 15;9(2):350-63.

Gresko E, Ritterhoff S, Sevilla-Perez J, Roscic A, Fröbius K, Kotevic I, Vichalkovski A, Hess D, Hemmings BA, Schmitz ML PML tumor suppressor is regulated by HIPK2-mediated phosphorylation in response to DNA damage Oncogene. 2009 Feb; 28(5):698-708

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