Patent details

Title (priority date) Modulating XRN2 (4.12.2008)
Reference: 53148
Inventors: Chatterjee & Grosshans
Description: This patent application relies on the surprising findings of the inventors that the 5-to-3 exonuclease xrn-2 (or XRN2), is an important component of miRNA turnover machinery. Their results indicate that degradation by XRN2 occurs on mature miRNAs, after they have been incorporated into miRNA-induced silencing complex (miRISC). Hence, degradation by XRN2 is an extemely important part of the miRNA metabolism circuit
Applications: Drug discovery. Screening. Novel target. Cancer therapy.
Status: Pending EP & US
Opportunity: Exclusive or non-exclusive license
Publications: Nature. 2009 Sep 24;461(7263):546-9
Contact: Dr. Nicolas Favre, tel: +41 61 697 8382,
PCT File: WO 2010/063783
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