Brian A. Hemmings

Most highly cited paper
Cross DAE, Alessi DR, Cohen P, Andjelkovich M, Hemmings BA (1995) Inhibition of glycogen synthase kinase-3 by insulin mediated by protein kinase B.
Nature 378, 785-789

More selected publications
Tang F, Zhang L, Xue G, Hynx D, Wang Y, Cron PD, Hundsrucker C, Hergovich A, Frank S, Hemmings BA, Schmitz-Röhmer D (2014) hMOB3 modulates MST1 apoptotic signaling and supports tumor growth in glioblastoma multiforme.
Cancer Res 74:3779-89

Grzmil M, Huber RM, Hess D, Frank S, Hynx D, Moncayo G, Klein D, Merlo A, Hemmings BA (2014) MNK1 pathway activity maintains protein synthesis in rapalog-treated gliomas.
J Clin Invest 124:742-754

Wang Y, Moncayo G, Morin P Jr, Xue G, Grzmil M, Lino MM, Clément-Schatlo V, Frank S, Merlo A, Hemmings BA (2013) Mer receptor tyrosine kinase promotes invasion and survival in glioblastoma multiforme.
Oncogene 32:872-882

Xue G, Restuccia DF, Lan Q, Hynx D, Dirnhofer S, Hess D, Rüegg C, Hemmings BA (2012) Akt/PKB-mediated phosphorylation of Twist1 promotes tumor metastasis via mediating cross-talk between PI3K/Akt and TGF-β signaling axes.
Cancer Discov 2:248-259

Zhuravleva E, Gut H, Hynx D, Marcellin D, Bleck CK, Genoud C, Cron P, Keusch JJ, Dummler B, Esposti MD, Hemmings BA (2012) Acyl coenzyme A thioesterase Them5/Acot15 is involved in cardiolipin remodeling and fatty liver development.
Mol Cell Biol 32:2685-2697

Cornils H, Kohler RS, Hergovich A, Hemmings BA (2011) Downstream of human NDR kinases: Impacting on c-myc and p21 protein stability to control cell cycle progression.
Cell Cycle 10:1897-904

Lu S, Nie J, Luan Q, Feng Q, Xiao Q, Chang Z, Shan C, Hess D, Hemmings BA, Yang Z (2011) Phosphorylation of the twist1-family basic helix-loop-helix transcription factors is involved in pathological cardiac remodeling.
PLoS One 6:e19251.

Grzmil M, Morin P Jr, Lino MM, Merlo A, Frank S, Wang Y, Moncayo G, Hemmings BA (2011) MAP kinase-interacting kinase 1 regulates SMAD2-dependent TGF-ß signaling pathway in human glioblastoma.
Cancer Res 71:2392-402

Cornils H, Kohler RS, Hergovich A, Hemmings BA (2011) Human NDR kinases control G(1)/S cell cycle transition by directly regulating p21 stability.
Mol Cell Biol 31:1382-95

Fayard E, Xue G, Parcellier A, Bozulic L, Hemmings BA (2011) Protein kinase B (PKB/Akt), a key mediator of the PI3K signaling pathway.
Curr Top Microbiol Immunol (CTMI) (ed) Vogt P, Rommel, Vanhaesebroeck B., Springer, Heidelberg 346:31-56

Restuccia DF, Hemmings BA (2010) From man to mouse and back again: advances in defining tumor AKTivities in vivo.
Dis Model Mech 3:705-20

Kohler RS, Schmitz D, Cornils H, Hemmings BA, Hergovich A (2011) Differential NDR/LATS interactions with the human MOB family reveal a negative role for human MOB2 in the regulation of human NDR kinases.
Mol Cell Biol 30:4507-20

Cornils H, Stegert MR, Hergovich A, Hynx D, Schmitz D, Dirnhofer S, Hemmings BA (2010) Ablation of the kinase NDR1 predisposes mice to the development of T cell lymphoma.
Sci Signal 3:ra47

Hergovich A, Hemmings BA (2010) TAZ-mediated crosstalk between Wnt and Hippo signaling.
Dev Cell 18(4):508-509

Vichalkovski A, Gresko E, Hess D, Restuccia DF, Hemmings BA (2010) PKB/AKT phosphorylation of the transcription factor Twist-1 at Ser42 inhibits p53 activity in response to DNA damage.
Oncogene 29:3554-65

Bozulic L, Hemmings BA (2009) PIKKing on PKB: regulation of PKB activity by phosphorylation.
Curr Opin Cell Biol 21:256-261

Grzmil M, Hemmings BA (2009) Deregulated signalling networks in human brain tumours.
Biochim Biophys Acta 1804(3):476-483

Hergovich A, Hemmings BA (2009) Mammalian NDR/LATS protein kinases in hippo tumor suppressor signaling.
Biofactors 35(4):338-45

Hergovich A, Kohler RS, Schmitz D, Vichalkovski A, Cornils H, Hemmings BA (2009) The MST1 and hMOB1 tumor suppressors control human centrosome duplication by regulating NDR kinase phosphorylation.
Curr Biol 19:1692-702

Parcellier A, Tintignac LA, Zhuravleva E, Cron P, Schenk S, Bozulic L, Hemmings BA (2009) Carboxy-Terminal Modulator Protein (CTMP) is a mitochondrial protein that sensitizes cells to apoptosis.
Cell Signal 21:639-650

Parcellier A, Tintignac LA, Zhuravleva E, Dummler B, Brazil DP, Hynx D, Cron P, Schenk S, Olivieri V, Hemmings BA (2009) The Carboxy-Terminal Modulator Protein (CTMP) regulates mitochondrial dynamics.
PLoS ONE. 4:e5471. Epub 2009 May 7

Park J, Feng J, Li Y, Hammarsten O, Brazil DP, Hemmings BA (2009) DNA-dependent protein kinase-mediated phosphorylation of protein kinase B requires a specific recognition sequence in the C-terminal hydrophobic motif.
J Biol Chem 284:6169-6174

Restuccia D, Hemmings BA (2009) Blocking Akt-ivity.
Science 325:1083-1084

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