Nancy E. Hynes

MacDonald G, Nalvarte I, Smirnova T, Vecchi M, Aceto N, Doelemeyer A, Frei A, Lienhard S, Wyckoff J, Hess D, Seebacher J, Keusch JJ, Gut H, Salaun D, Mazzarol G, Disalvatore D, Bentires-Alj M, Di Fiore PP, Badache A, Hynes NE (2014) Memo is a copper-dependent redox protein with an essential role in migration and metastasis.
Sci Signal 7:ra56

Haenzi B, Bonny O, Masson R, Lienhard S, Dey JH, Kuro-o M, Hynes NE (2014) Loss of Memo, a novel FGFR regulator, results in reduced lifespan.
FASEB J 28:327-336

Hynes NE, Ingham PW, Lim WA, Marshall CJ, Massague J, Pawson T (2013) Signaling change: signal transduction through the decades.
Nat Rev Mol Cell Biol 14:393-398

Gattelli A, Nalvarte I, Boulay A, Roloff TC, Schreiber M, Carragher N, Macleod KK, Schlederer M, Lienhard S, Kenner L, Torres-Arzayus MI, Hynes NE (2013) Ret inhibition decreases growth and metastatic potential of estrogen receptor positive breast cancer cells.
EMBO Mol Med 5:1335-1350

Issa A, Gill JW, Heideman MR, Sahin O, Wiemann S, Dey JH, Hynes NE (2013) Combinatorial targeting of FGF and ErbB receptors blocks growth and metastatic spread of breast cancer models.
Breast Cancer Res 15:R8

Heinrich C, Keller C, Boulay A, Vecchi M, Bianchi M, Sack R, Lienhard S, Duss S, Hofsteenge J, Hynes NE (2010) Copine-III interacts with ErbB2 and promotes tumor cell migration.
Oncogene 29:1598-610

Boulay A, Breuleux M, Stephan C, Fux C, Brisken C, Fiche M, Stumm M, Lane HA, Hynes NE (2009) The Ret receptor tyrosine kinase functionally interacts with the ER-alpha pathway in breast cancer.
Cancer Res 68: 3743-3751

Fayard B, Bianchi F, Dey J, Moreno E, Djaffer S, Hynes NE*, Monard D* (2009) The serine protease inhibitor protease nexin-1 controls mammary cancer metastasis through LRP-1-mediated MMP-9 expression.
Cancer Res 69:5690-8
*joint senior authors

Hynes NE, Dey JH (2009) PI3K inhibition overcomes trastuzumab resistance: blockade of ErbB2/ErbB3 is not always enough.
Cancer Cell 15:353-355

Hynes NE, MacDonald G (2009) ErbB receptors and signaling pathways in cancer.
Curr Opin Cell Biol 21:177-184

Hynes NE, Stoelzle T (2009) Key signalling nodes in mammary gland development and cancer: Myc.
Breast Cancer Res 11:210

Matsuda Y, Schlange T, Oakeley EJ, Boulay A, Hynes NE (2009) Wnt signaling enhances breast cancer cell motility and blockade of the Wnt pathway by sFRP1 suppresses MDA-MB-231 xenograft growth.
Breast Cancer Res 11:R32

Meira M, Masson R, Stagljar I, Lienhard S, Maurer F, Boulay A, Hynes NE (2009) Memo is a novel cofilin interacting protein that influences PLCg1 and cofilin activities, and is essential for maintaining directionality during ErbB2 induced tumor cell migration.
J Cell Sci 122:787-797

Stoelzle T, Schwarb P, Trumpp A, Hynes NE (2009) c-Myc affects mRNA translation, cell proliferation and progenitor cell function in the mammary gland.
BMC Biol 7:63

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