Silvia Arber

Group News

Jun 1, 2019
Interview Werner Arber & Silvia Arber
Mar 25, 2019
Silvia Arber receives the International Prize of the Fyssen Foundation
Mar 7, 2019
Transfer of FMI Directorship: Silvia Arber and Dirk Schübeler to be co-directors
Mar 1, 2019
Understanding the brain & spinal cord connection in the nervous system – Interview Silvia Arber
Aug 23, 2018
Motor cortex needed for sensory-guided control of movement
All group news

Resources

FMI report pages
Biozentrum - Silvia Arber Group

Silvia Arber

Motor circuit function

Our studies aim at identifying the principles by which neuronal circuits orchestrate accurate and timely control of motor behavior. We thrive to understand how the nervous system can produce a large repertoire of movement patterns, covering diverse motor actions from locomotion to skilled forelimb tasks. To decipher how motor circuits engage in the control of movement and contribute to the generation of diverse actions, we unravel how neuronal subpopulations are organized into specific circuits, and we study the function of identified circuits in execution and learning of motor programs.

We address these questions using multi-facetted approaches combining many technologies. These include state-of-the-art mouse genetics, development and implementation of viral technologies for transsynaptic circuit tracing and functional manipulation by opto- and pharmacogenetics, quantitative behavioral analysis, electrophysiology and gene expression profiling of identified neuronal subpopulations.

The combination of these approaches allows us to assess connectivity and manipulate function in order to determine the role of defined circuit elements in animal behavior. Furthermore, they also enable us to uncover mechanisms involved in motor circuit assembly during development, as well as circuit plasticity during motor learning and in response to disease or injury.

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Silvia Arber

This is a list of selected publications from this group. For a full list of publications, please visit our Publications page and search by group name.


Ruder L, Arber S (2019) Brainstem Circuits Controlling Action Diversification.

Annu Rev Neurosci. 42:485-504

Takeoka A, Arber S (2019) Functional Local Proprioceptive Feedback Circuits Initiate and Maintain Locomotor Recovery after Spinal Cord Injury.

Cell Rep 27(1):71-85.e3

Ferreira-Pinto MJ, Ruder L, Capelli P, Arber S. (2018) Connecting Circuits for Supraspinal Control of Locomotion.

Neuron 100(2):361-374

Heindorf M, Arber S, Keller GB (2018) Mouse Motor Cortex Coordinates the Behavioral Response to Unpredicted Sensory Feedback

Neuron 99:1040-1050.e5

Capelli P, Pivetta C, Soledad Esposito M, Arber S (2017) Locomotor speed control circuits in the caudal brainstem

Nature [Epub ahead of print]

Ruder L, Takeoka A, Arber S. (2016) Long-distance descending spinal neurons ensure quadrupedal locomotor stability

Neuron 92:1063-1078

Satoh D, Pudenz C, Arber S (2016) Context-dependent gait choice elicited by EphA4 mutation in Lbx1 spinal interneurons

Neuron 89:1046-1058

Basaldella E, Takeoka A, Sigrist M, Arber S (2015) Multisensory signaling shapes vestibulo-motor circuit specificity

Cell 163:301-312

Goetz C, Pivetta C, Arber S (2015) Distinct limb and trunk premotor circuits establish laterality in the spinal cord

Neuron 85:131-144

Takeoka A, Vollenweider I, Courtine G, Arber S (2014) Muscle spindle feedback directs locomotor recovery and circuit reorganization after spinal cord injury

Cell 159:1626-1639

Esposito MS, Capelli P, Arber S (2014) Brainstem nucleus MdV mediates skilled forelimb motor tasks

Nature 508:351-356

Pivetta C, Esposito MS, Sigrist M,Arber S (2014) Motor-circuit communication matrix from spinal cord to brainstem neurons revealed by developmental origin

Cell 156:537-548

Arber S (2012) Motor circuits in action: specification, connectivity, and function

Neuron 74:975-989

Tripodi M, Arber S (2012) Regulation of motor circuit assemblyby spatial and temporal mechanisms

Curr Opin Neurobiol 22:615-623

Tripodi M, Stepien AE, Arber S (2011) Motor antagonism exposed by spatial segregation and timing of neurogenesis

Nature. 479:61-66

Stepien AE, Tripodi M, Arber S (2010) Monosynaptic rabies virus reveals premotor network organization and synaptic specificity of cholinergic partition cells

Neuron 68:456-472

Pecho-Vrieseling E, Sigrist M, Yoshida Y, Jessell TM, Arber S (2009) Specificity of sensory-motor connections encoded by Sema3e-Plxnd1 recognition

Nature, 459:842-6

Ladle DR, Pecho-Vrieseling E, Arber S (2007) Assembly of motor circuits in the spinal cord: driven to function by genetic and experience-dependent mechanisms

Neuron 56:270-283

Kramer I, Sigrist M, de Nooij JC, Taniuchi I, Jessell TM, Arber S (2006) A role for Runx transcription factor signaling in dorsal root ganglion sensory neuron diversification

Neuron 49:379-393

Vrieseling E, Arber S (2006) Target-induced transcriptional control of dendritic patterning and connectivity in motor neurons by ETS gene Pea3

Cell 127:1439-1452

Hippenmeyer S, Vrieseling E, Sigrist M, Portmann T, Laengle C, Ladle DR, Arber S (2005) A developmental switch in the response of DRG neurons to ETS transcription factor signaling

PLoS Biol. 3:e159

Full list of publications
» Search with Medline

Members

Group leader


PhD students


Postdoctoral fellows


Technical/Research associates


Undergraduates


Alumni

PhD students

Ludwig Ruder (2013-2019)
Paolo Capelli (2011-2018)
Matthias Heindorf (2012-2017)
Emanuela Basaldella (2010-2016)
Cyrill Goetz (2011-2015)
Chiara Pivetta (2009-2015)
Christiane Pudenz (2010-2014)
Anna Stepien (2005-2011)
Jun Lee (2005-2011)
Neha Rajadhyaksha (2009-2011)
Andrea Sieber (2008-2009)
Simon Dalla Torre (2004-2009)
Andreas Friese (2003-2008)
Roland Huber (2006-2007)
Marlies Muernseer (2006-2007)
Eline Pecho Vrieseling (2001-2006)
Rishard Salie (2001-2005)
Ina Kramer (2000-2005)
Vera Niederkofler (2000-2005)
Simon Hippenmeyer (2000-2004)

Postdoctoral fellows

Maria Soledad Esposito (2008-2018)
Sara Valencia Garcia (2015-2018)
Fabien Alcaraz (2016-2018)
Aya Takeoka (2010-2016)
Daisuke Satoh (2010-2016)
Sheyla Mejia Gervacio (2012-2015)
Marco Tripodi (2008-2013)
Celine Jean-Xavier (2008-2011)
Eline Pecho Vrieseling (2007-2008)
David Ladle (2002-2008)
Stan Nakanishi (2005-2006)
Simon Hippenmeyer (2004-2006)
Ina Kramer (2005-2006)

Undergraduates

Artur Schmidt (2014-2016)
Inka Busack (2014)
Keith Gunapala (2014)
Mildred Alejandra Gutierrez Herrera (2013-2014)
Ludwig Ruder (2012)
Naomi Walker (2012)
Cyrill Goetz (2010-2011)
Sibel Guerler (2008-2010)
Vito Lotito (2009)
Milica Petrovic (2008-2009)
Joachim Luginbuehl (2006-2008)
Alison Kate Macintyre (2006-2007)
Roland Huber (2005-2006)
Jennifer Henaghan (2005)
Claudia Suenderhauf (2004)
Celia Laengle (2003-2004)
Thomas Portmann (2002-2004)
Simon Strobel (2000-2001)

Visiting scientists

Antonio Falasconi (2019)
Celina Hartmann (2016)
Kohdai Muraki (2016)
Sabine Brodbeck (2002)

Education

1995
PhD, University of Basel, Basel, Switzerland
1991
BSc, University of Basel, Basel, Switzerland

Positions held

2019-
Co-Director FMI
2008-
Full Professor for Neurobiology/Cell Biology, Biozentrum, University of Basel, Basel
2004-2008
Associate Professor for Neurobiology/Cell Biology, Biozentrum, University of Basel, Basel
2004-
Senior Group Leader, Friedrich Miescher Institute for Biomedical Research, Basel, Switzerland
2000-2004
Assistant Professor for Neurobiology/Cell Biology, Biozentrum, University of Basel, Basel and Friedrich Miescher Institute for Biomedical Research,Basel, Switzerland
1996-2000
Postdoctoral Fellow, Columbia University, HHMI, New York

Honors

2019
International Prize of the Fyssen Foundation
2018
Pradel Research Award
2017
Novartis VIVA Leading Scientist Award
2017
Louis-Jeantet Prize for Medicine
2016
ERC Advanced Grant
2015
Remedios Caro Almela Prize in Developmental Neurobiology
2014
Basel City Award
2014
Otto Naegeli Prize
2008
Friedrich Miescher Award
2008
Schellenberg Prize
2005
EMBO Member
2004
Member, Swiss Academy of Medical Sciences
2003
National Latsis Prize
2001
EMBO Young Investigator Award 2000
1999
Human Frontier Science Program Award for Young Investigators
1998-2000
Swiss National Science Foundation Fellowship
1998
Pfizer Research Prize
1997
Best Thesis of the Year, Faculty of Natural Sciences, University of Basel
1996-1998
Human Frontier Science Program (HFSP) Long-Term Fellowship
1996-1996
EMBO Long-Term Fellowship
1996
E. Fisher Best Thesis Prize, Friedrich Miescher Institute for Biomedical Research, Basel
1992-1994
Swiss Foundation for Research on Muscle Diseases Fellowship