Nicolas Thomä
Group News
Nov 17, 2023 Zuzanna Kozicka awarded Science & SciLifeLab Prize for Young Scientists |
Oct 4, 2023 Small molecules to treat big diseases |
Oct 3, 2023 Nicolas Thomä leaving the FMI |
Apr 26, 2022 Nicolas Thomä receives the Otto Naegeli Prize 2022 |
Apr 26, 2022 Basel biologist wins science prize for thalidomide insights |
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Nicolas Thomä
The molecular basis of genome maintenance
The information stored in the genome of each cell is constantly protected against endogenous and exogenous attack. Enzymatic maintenance processes are in place that repair mutations and prevent duplication or deletion events. Thus, genetic and epigenetic information is faithfully passaged to the progeny. On a biomedical level, defects in these pathways are frequently associated with cancer. Genome integrity is maintained through large multi-component nano-machines. We focus on protein complexes at the interface of DNA repair, replication and chromatin. My laboratory has set out to combine structural biology, cell biology and complex biochemical in vitro reconstitutions to address the molecular workings of these chromatin-bound complex assemblies. Our focus is on machines that detect and repair mutations in the DNA, and those that make possible the accurate passage of epigenetic information to the daughter generation.
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Nicolas Thomä
Understanding life, advancing medicine — Nicolas Thomä talks about his fascination with proteins and his work on "molecular glues", small molecules that have the potential to treat tough diseases.
April 26, 2022
TED talk by Nico Thomä
Protein superglue! What this means for drug discovery
May 11, 2019 - Basel
This is a list of selected publications from this group. For a full list of publications, please visit our Publications page and search by group name.
Pathare GR, Decout A, Glück S, Cavadini S, Makasheva K, Hovius R, Kempf G, Weiss J, Kozicka Z, Guey B, Melenec P, Fierz B, Thomä NH, Ablasser A. (2020) Structural mechanism of cGAS inhibition by the nucleosome.
Nature. 2020 Nov;587(7835):668-672Kassube SA, Thomä NH (2020) Structural insights into Fe-S protein biogenesis by the CIA targeting complex.
Nat Struct Mol Biol. 2020 Aug;27(8):735-742Slabicki M, Kozicka Z, Petzold G, Li YD, Manojkumar M, Bunker RD, Donovan KA, Sievers QL, Koeppel J, Suchyta D, Sperling AS, Fink EC, Gasser JA, Wang LR, Corsello SM, Sellar RS, Jan M, Gillingham D, Scholl C, Fröhling S, Golub TR, Fischer ES, Thomä NH, Ebert BL. (2020) The CDK inhibitor CR8 acts as a molecular glue degrader that depletes cyclin K.
Nature. 2020 Sep;585(7824):293-297Michael AK, Grand RS, Isbel L, Cavadini S, Kozicka Z, Kempf G, Bunker RD, Schenk AD, Graff-Meyer A, Pathare GR, Weiss J, Matsumoto S, Burger L, Schübeler D, Thomä NH. (2020) Mechanisms of OCT4-SOX2 motif readout on nucleosomes.
Science. 2020 Jun 26;368(6498):1460-1465.Schenk AD, Cavadini S, Thomä NH, Genoud C (2020) Live Analysis and Reconstruction of Single-Particle Cryo-Electron Microscopy Data with CryoFLARE.
J Chem Inf Model. 2020 May 26Rabl J, Bunker RD, Schenk AD, Cavadini S, Gill ME, Abdulrahman W, Andrés-Pons A, Luijsterburg MS, Ibrahim AFM, Branigan E, Aguirre JD, Marceau AH, Guérillon C, Bouwmeester T, Hassiepen U, Peters AHFM, Renatus M, Gelman L, Rubin SM, Mailand N, van Attikum H, Hay RT, Thomä NH (2019) Structural Basis of BRCC36 Function in DNA Repair and Immune Regulation.
Mol Cell. 2019 Aug 8;75(3):483-497.e9Matsumoto S, Cavadini S, Bunker RD, Grand RS, Potenza A, Rabl J, Yamamoto J, Schenk AD, Schübeler D, Iwai S, Sugasawa K, Kurumizaka H, Thomä NH (2019) DNA damage detection in nucleosomes involves DNA register shifting.
Nature. 2019 Jul;571(7763):79-84Sievers QL, Petzold G, Bunker RD, Renneville A, Slabicki M, Liddicoat BJ, Abdulrahman W, Mikkelsen T, Ebert BL, Thomä NH (2018) Defining the human C2H2 zinc finger degrome targeted by thalidomide analogs through CRBN
Science. 2018 Nov 2;362(6414)Fischer ES, Böhm K, Lydeard JR, Yang H, Stadler MB, Cavadini S, Nagel J, Serluca F, Acker V, Lingaraju GM, Tichkule RB, Schebesta M, Forrester WC, Schirle M, Hassiepen U, Ottl J, Hild M, Beckwith RE, Harper JW, Jenkins JL, Thomä NH (2014) Structure of the DDB1-CRBN E3 ubiquitin ligase in complex with thalidomide
Nature 512:49-53Lingaraju GM, Bunker RD, Cavadini S, Hess D, Hassiepen U, Renatus M, Fischer ES, Thomä NH (2014) Crystal structure of the human COP9 signalosome
Nature. 2014 Jul 16. doi: 10.1038/nature13566. [Epub ahead of print]Bocquet N, Bizard AH, Abdulrahman W, Larsen NB, Faty M, Cavadini S, Bunker RD, Kowalczykowski SC, Cejka P, Hickson ID, Thomä NH (2014) Structural and mechanistic insight into Holliday-junction dissolution by topoisomerase IIIa and RMI1
Nat Struct Mol Biol. 21:261-8Shi T, Bunker RD, Mattarocci S, Ribeyre C, Faty M, Gut H, Scrima A, Rass U, Rubin SM, Shore D, Thomä NH (2013) Rif1 and Rif2 shape telomere function and architecture through multivalent Rap1 interactions
Cell 153:1340-53Fischer ES, Scrima A, Böhm K, Matsumoto S, Lingaraju GM, Faty M, Yasuda T, Cavadini S, Wakasugi M, Hanaoka F, Iwai S, Gut H, Sugasawa K, Thomä NH (2011) The molecular basis of CRL4(DDB2/CSA) ubiquitin ligase architecture, targeting and release of signalosome inhibition
Cell, 147, 5, 1024-1039Schmitges FW, Prusty AB, Faty M, Stützer A, Lingaraju GM, Aiwazian J, Sack R, Hess D, Li L, Zhou S, Bunker RD, Wirth U, Bouwmeester T, Bauer A, Ly-Hartig N, Zhao K, Chan H, Gu J, Gut H, Fischle W, Müller J, Thomä NH (2011) Histone methylation by PRC2 is inhibited by active chromatin marks
Mol Cell 42:330-41.Scrima A, Konickova R, Czyzewski B, Kawasaki Y, Jeffrey P, Groisman R, Nakatani Y, Iwai S, Pavletich N, Thomä N (2008) Structural basis of UV DNA-damage recognition by the DDB1-DDB2 complex
Cell 135:1213-1223Full list of publications
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