Dec 4, 2019
Safeguarding one-way traffic
Jan 14, 2019
A metabolic checkpoint for embryonic stem cell differentiation
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Cell fate transitions
Cell identity is encoded in self-propagating regulatory networks that confer cell state stability. Most cells, however, acquire their identity during development by transiting through progressively restricted cell states. Thus, destabilization of existing and emergence of prospective regulatory networks underlies cell fate determination, and is reflected in the lineage progression from stem and progenitor cells into mature cell types.
In order to execute differentiation, stem and progenitor networks have to be dispersed and differentiation-specific circuits need to be established. Failure to do so infringes development and tissue regeneration, and also contributes to tumor-propagation. While cell identity networks are fairly well described, transitions between them are less studied.
Our research aims at deciphering mechanisms and logics driving cell state transitions using pluripotent stem cells as a paradigm. In particular, by combining genetic and biochemical approaches, we target the identification of modules that regulate cell state changeover, to specify the underlying network dynamics, and to deduce routines conferring network plasticity.
This is a list of selected publications from this group. For a full list of publications, please visit our Publications page and search by group name.
Mayer D, Stadler MB, Rittirsch M, Hess D, Lukonin I, Winzi M, Smith A, Buchholz F, Betschinger J (2020) Zfp281 orchestrates interconversion of pluripotent states by engaging Emht1 and Zic2EMBO J. 39:e102591
Villegas F, Lehalle D, Mayer D, Rittirsch M, Stadler MB, Zinner M, Olivieri D, Vabres P, Duplomb-Jego L, de Bont JM, Duffourd Y, Duijkers F, Avila M, Geneviève D, Houcinat N, Jouan T, Kuentz P, Lichtenbelt KD, Thauvin-Robinet C, St-Onge J, Thevenon J, van Gassen KLI, van Haelst M, van Koningsbruggen S, Hess D, Smallwood S, Rivière J, Faivre L, Betschinger J (2019) Lysosomal signaling licenses embryonic stem cell differentiation via inactivation of Tfe3Cell Stem Cell. 24(2):257-270
Betschinger J (2017) Charting developmental dissolution of pluripotencyJ Mol Biol. 429(10):1441-58.
Betschinger J, Nichols J, Dietmann S, Corrin PS, Paddison PJ, Smith A (2013) Exit from Pluripotency is Gated by Intracellular Redistribution of the bHLH Transcription Factor Tfe3Cell 153(2): 335-47
Betschinger J, Mechtler K, Knoblich JA (2006) Asymmetric Segregation of the Tumor Suppressor Brat Regulates Self-Renewal in Drosophila Neural Stem CellsCell 124(6): 1241-53
Betschinger J, Mechtler K, Knoblich JA (2003) The Par Complex Directs Asymmetric Cell Division by Phosphorylating the Cytoskeletal ProteinNature 422(6929): 326-30
Full list of publications
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