Patrick Matthias
Group News
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Jan 2, 2024 Cracking the secrets of virus ‘uncoating’ may help fight infections |
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May 11, 2022 Thwarting cellular enzyme can fight viral infections |
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Apr 20, 2022 Structural insights into the assembly of cilia |
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Feb 1, 2021 A key regulator for humoral immunity and B lymphoma |
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Resources
Patrick Matthias
Transcriptional and epigenetic networks and function of HDACs in mammals
Molecular mechanism underlying plasticity
Stem cells give rise to differentiated cells through gradual establishment of lineage-specific gene expression programs. These result from a complex interplay of signal transduction cascades, genetic hierarchies of transcription factors and epigenetic chromatin modifiers. This creates a molecular code unique to each cell type that defines its properties and fate.
We are interested in the molecular mechanisms underlying cellular plasticity and cell-specific gene expression in a genetically tractable system and concentrate on the transcriptional and epigenetic control of lymphoid (B) cell development. For this, we study several transcription factors and epigenetic regulators that may be relevant for B cell development.
Focus on HDACs
In addition, we have a central focus on histone deacetylases (HDACs). Acetylation of histones represents a crucial epigenetic annotation of chromatin, which participates significantly in the regulation of gene expression. In addition, non-histone protein acetylation is involved in an expanding range of cellular processes. HDACs remove acetyl groups from histone N-terminal tails and thereby contribute to chromatin condensation and to the modulation of gene expression. Although the biological role of HDACs in mammals is still poorly understood, it is clear that these proteins are important in cancer as well as in various other diseases such as autoimmunity or neurodegeneration. HDACs therefore are valuable potential therapeutic targets in a number of pathological settings.
We use a broad range of methods, including the generation and analysis of transgenic or conditionally targeted mice as well as functional genomics and proteomics.
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Patrick Matthias
This is a list of selected publications from this group. For a full list of publications, please visit our Publications page and search by group name.
Choukrallah MA, Matthias P (2014) The interplay between chromatin and transcription facto networks during B cell development: who pulls the trigger first?
Front Immunol 5:15Du Roure C, Versavel A, Doll T, Cao C, Pillonel V, Matthias G, Kaller M, Spetz JF, Kopp P, Kohler H, Müller M, Matthias P (2014) Hematopoietic overexpression of FOG1 does not affect B-cells but reduces the number of circulating eosinophils
PLOS One 9:e92836Brunmeir R, Lagger S, Simboeck E, Sawicka A, Egger G, Hagelkruys A, Zhang Y, Matthias P, Miller WJ, Seiser C (2010) Epigenetic regulation of a murine retrotransposon by a dual histone modification mark
PLoS Genet 6:e1000927Yamaguchi T, Cubizolles F, Zhang Y, Reichert N, Kohler H, Seiser C, Matthias P (2010) Histone deacetylases 1 and 2 act in concert to promote the G1-to-S progression
Genes Dev 24:455-69Bordon A, Bosco N, Du Roure C, Bartholdy B, Matthias G, Rolink AG, Matthias P (2008) Enforced expression of the transcriptional coactivator OBF1 impairs B cell differentiation at the earliest stage of development
PloS ONE. 3:e4007. Epub 2008 Dec 23Karnowski A, Cao C, Matthias G, Carotta S, Corcoran LM, Martensson IL, Skok JA, Matthias P (2008) Silencing and nuclear repositioning of the l5 gene locus at the pre-B cell stage require Aiolos and OBF-1
PLoS ONE. 3:e3568. Epub 2008 Oct 30Matthias P, Yoshida M, Khochbin S (2008) HDAC6 a new cellular stress surveillance factor
Cell Cycle 7:7-10Zhang Y, Kwon S, Yamaguchi T, Cubizolles F, Rousseaux S, Kneissel M, Cao C, Li N, Cheng HL, Chua K, Lombard D, Mizeracki A, Matthias G, Alt FW, Khochbin S, Matthias P (2008) Mice lacking histone deacetylase 6 have hyperacetylated tubulin but are viable and develop normally
Mol Cell Biol 28:1688-1701Boyault C, Zhang Y, Fritah S, Caron C, Gilquin B, Kwon SH, Garrido C, Yao TP, Vourc'h C, Matthias P, Khochbin S (2007) HDAC6 controls major cell response pathways to cytotoxic accumulation of protein aggregates
Genes Dev 21:2172-2181Kwon S, Zhang Y, Matthias P (2007) The deacetylase HDAC6 is a novel critical component of stress granules involved in the stress response
Genes Dev 21:3381-3394Bartholdy B, Du Roure C, Bordon A, Emslie D, Corcoran LM, Matthias P (2006) The Ets factor Spi-B is a direct critical target of the coactivator OBF-1
Proc Natl Acad Sci USA 103:11665-11670Boyault C, Gilquin B, Zhang Y, Rybin V, Garman E, Meyer-Klaucke W, Matthias P, Müller CW, Khochbin S (2006) HDAC6-p97/VCP controlled polyubiquitin chain turnover
EMBO J 25:3357-3366Matthias P, Rolink AG (2005) Transcriptional networks in developing and mature B cells
Nature Rev Immunol 5:497-508Bartholdy B, Matthias P (2004) Transcriptional control of B cell development and function
Gene 327:1-23Lins K, Remenyi A, Tomilin A, Massa S, Wilmanns M, Matthias P, Scholer HR (2003) OBF1 enhances transcriptional potential of Oct1
EMBO J 22:2188-2198Sun J, Matthias G, Mihatsch MJ, Georgopoulos K, Matthias P (2003) Lack of the transcrip- tional coactivator OBF-1 prevents the devel- opment of systemic lupus erythematosus- like phenotypes in Aiolos mutant mice
J Immunol 170:1699-1706Zhang Y, Li N, Caron C, Matthias G, Hess D, Khochbin S, Matthias P (2003) HDAC-6 interacts with and deacetylates tubulin and microtubules in vivo
EMBO J 22:1168-1179Schubart K, Massa S, Schubart D, Corcoran LM, Rolink AG, Matthias P (2001) B cell development and immunoglobulin gene transcription in the absence of Oct-2 and OBF-1
Nature Immunol 2:69-74Tiedt R, Bartholdy BA, Matthias G, Newell JW, Matthias P (2001) The RING finger protein Siah-1 regulates the level of the transcrip- tional coactivator OBF-1
EMBO J 20:4143-4152Full list of publications
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Members
Group leader
In current position since 1991
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PhD students
In current position since 2020
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Postdoctoral fellows
In current position since 2018
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In current position since 2023
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In current position since 2021
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Technical/Research associates
In current position since 2006
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In current position since 1997
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