Helge Grosshans

Aeschimann, F., Neagu, A., Rausch, M., and Grosshans, H. (2019) A single let-7 target to coordinate transition to adulthood.
Life Science Alliance 2, e201900335

Pereira, L., Aeschimann, F., Wang, C., Lawson, H., Serrano-Saiz, E., Portman, D.S., Grosshans, H., Hobert, O. (2019) Timing mechanism of sexually dimorphic nervous system differentiation.
eLIFE 8: e42078.

Kumari, P.*, Aeschimann, F.*, Gaidatzis, D.*, Keusch, J.J.*, Ghosh, P., Neagu, A., Pachulska-Wieczorek, K., Bujnicki, J.M., Gut, H., Grosshans, H., Ciosk, R. (2018) Evolutionary plasticity of the NHL domain underlies distinct solutions to RNA recognition.
Nat. Commun. 9: 1549
* Equal contribution

Brancati, G., and Grosshans, H. (2018) An interplay of miRNA abundance and target site architecture determines miRNA activity and specificity.
Nucleic Acids Res. 46: 3259-3269

Miki TS, Carl SH, Grosshans H (2017) Two distinct transcription termination modes dictated by promoters.
Genes Dev. 31: 1870-1879.

Aeschimann F, Kumari P, Bartake H, Gaidatzis D, Xu L, Ciosk R, Grosshans H (2017) LIN41 post-transcriptionally silences mRNAs by two distinct and position-dependent mechanisms.
Mol Cell 65:476-489.

Richter H, Katic I, Gut H, Grosshans H (2016) Structural basis and function of XRN2 binding by XTB domains.
Nat Struct Mol Biol 23:164-71

de la Mata M, Gaidatzis D, Vitanescu M, Stadler MB, Wentzel C, Scheiffele P, Filipowicz W, Grosshans H (2015) Potent degradation of neuronal miRNAs induced by highly complementary targets.
EMBO Rep 16:500-11

Ecsedi M, Rausch M Grosshans H (2015) The let-7 microRNA directs vulval development through a single target.
Dev Cell 32:335-44

Hendriks GJ, Gaidatzis D, Aeschimann F, Grosshans H (2014) Extensive oscillatory gene expression during C. elegans larval development.
Mol Cell 53:380-92.

Katic I, Grosshans H (2013) Targeted heritable mutation and gene conversion by Cas9-CRISPR in Caenorhabditis elegans.
Genetics 195:1173-6

Chatterjee S, Fasler M, Büssing I, Grosshans H (2011) Target-mediated protection of endogenous microRNAs in C. elegans.
Dev Cell 20:388-396

Büssing I, Yang J-S, Lai EC, Grosshans H (2010) The nuclear export receptor XPO-1 supports primary miRNA processing in C. elegans and Drosophila..
EMBO J 29:1830-1839

Chatterjee S, Grosshans H (2009) Active turnover modulates mature microRNA activity in C. elegans.
Nature 461:546-549

Ding XC, Grosshans H (2009) Repression of C. elegans microRNA targets at the initiation level of translation requires GW182 proteins.
EMBO J 28:213-222

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