Posttranscriptional gene regulationGene expression is controlled at many levels, including by mRNA regulation. Whether a particular mRNA is translated, repressed, or degraded, depends on its interactions with a variety of RNA-binding proteins (RBPs) and regulatory RNAs, which in turn recruit diverse co-factors. Our interest is in elucidating the molecular mechanisms by which conserved RBPs control mRNA fate. We are also interested in explaining how these mechanisms influence fundamental biological processes explained below.
Molecular principles of cellular and metabolic plasticityCellular reprograming is fundamental for development and tissue homeostasis. A profound developmental reprograming occurs during the transition from a differentiated germ cell to a pluripotent embryo. This reprograming is critical for the formation of a new individual and for the life cycle to continue. In the past, we demonstrated a critical role for both epigenetic and cytoplasm-based, posttranscriptional mechanisms, in controlling developmental reprograming. In addition to this line of research, we became interested in metabolic reprograming, which we study in the context of obesity and adaptation to extreme cold, with important biomedical implications.
FMI report pages for Rafal Ciosk