Yoshikuni Nagamine

Signal transduction and the plasminogen activator system

The plasminogen activator (PA) system plays an important role in processes involving extracellular proteolysis, such as angiogenesis, wound healing, gametogenesis, inflammation and tumor metastasis.
Recent results show a new form of biological regulation by the PA system not involving proteolytic activity in which urokinase-type PA (uPA)-occupied uPA receptor acquires a high affinity for vitronectin, promoting cell adhesion or migration on vitronectin-containing extracellular matrix. Studying regulation of uPA and PA inhibitor-1 by growth factors, we found serine/threonine phosphorylation of the adaptor/docking protein ShcA. Tyrosine phosphorylation of ShcA and its role in signaling have been well documented, but its serine/threonine phosphorylation has been little studied. Our work has revealed a role for serine phosphorylation of ShcA in insulin induced signaling.

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FMI report pages for Yoshikuni Nagamine

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Yoshikuni Nagamine
Gabi Gruber