Brian A. Hemmings
Brian A. Hemmings
Targeting the cancer kinome
Judging simply by the abundance of protein kinase and protein phosphatase genes, protein phosphorylation is a very important regulatory mechanism. Our current work focuses on the role of these enzymes in eukaryotic signaling pathways and their possible implications in human diseases.
Signal transduction pathways in mammalian cells function through the coordinated activation, or inactivation of protein kinases and phosphatases localized in the cell membrane, cytoplasm or nucleus. Many human diseases result from deregulation of signal transduction pathways; for example, the proliferation signal pathways of cancer cells are permanently upregulated following mutation of key regulatory enzymes.
Our current research activities focus on targeting novel kinases involved in the development and progression of glioblastoma, ovarian cancer and lymphoma with the ultimate aim of finding new personalized therapeutic strategies.
Most highly cited paper
Cross DAE, Alessi DR, Cohen P, Andjelkovich M, Hemmings BA (1995) Inhibition of glycogen synthase kinase-3 by insulin mediated by protein kinase B
Tang F, Zhang L, Xue G, Hynx D, Wang Y, Cron PD, Hundsrucker C, Hergovich A, Frank S, Hemmings BA, Schmitz-Röhmer D (2014) hMOB3 modulates MST1 apoptotic signaling and supports tumor growth in glioblastoma multiforme
Cancer Res 74:3779-89Grzmil M, Huber RM, Hess D, Frank S, Hynx D, Moncayo G, Klein D, Merlo A, Hemmings BA (2014) MNK1 pathway activity maintains protein synthesis in rapalog-treated gliomas
J Clin Invest 124:742-754Wang Y, Moncayo G, Morin P Jr, Xue G, Grzmil M, Lino MM, Clément-Schatlo V, Frank S, Merlo A, Hemmings BA (2013) Mer receptor tyrosine kinase promotes invasion and survival in glioblastoma multiforme
Oncogene 32:872-882Xue G, Restuccia DF, Lan Q, Hynx D, Dirnhofer S, Hess D, Rüegg C, Hemmings BA (2012) Akt/PKB-mediated phosphorylation of Twist1 promotes tumor metastasis via mediating cross-talk between PI3K/Akt and TGF-β signaling axes
Cancer Discov 2:248-259Zhuravleva E, Gut H, Hynx D, Marcellin D, Bleck CK, Genoud C, Cron P, Keusch JJ, Dummler B, Esposti MD, Hemmings BA (2012) Acyl coenzyme A thioesterase Them5/Acot15 is involved in cardiolipin remodeling and fatty liver development
Mol Cell Biol 32:2685-2697Cornils H, Kohler RS, Hergovich A, Hemmings BA (2011) Downstream of human NDR kinases: Impacting on c-myc and p21 protein stability to control cell cycle progression
Cell Cycle 10:1897-904Lu S, Nie J, Luan Q, Feng Q, Xiao Q, Chang Z, Shan C, Hess D, Hemmings BA, Yang Z (2011) Phosphorylation of the twist1-family basic helix-loop-helix transcription factors is involved in pathological cardiac remodeling
PLoS One 6:e19251.Grzmil M, Morin P Jr, Lino MM, Merlo A, Frank S, Wang Y, Moncayo G, Hemmings BA (2011) MAP kinase-interacting kinase 1 regulates SMAD2-dependent TGF-ß signaling pathway in human glioblastoma
Cancer Res 71:2392-402Cornils H, Kohler RS, Hergovich A, Hemmings BA (2011) Human NDR kinases control G(1)/S cell cycle transition by directly regulating p21 stability
Mol Cell Biol 31:1382-95Fayard E, Xue G, Parcellier A, Bozulic L, Hemmings BA (2011) Protein kinase B (PKB/Akt), a key mediator of the PI3K signaling pathway
Curr Top Microbiol Immunol (CTMI) (ed) Vogt P, Rommel, Vanhaesebroeck B., Springer, Heidelberg 346:31-56Restuccia DF, Hemmings BA (2010) From man to mouse and back again: advances in defining tumor AKTivities in vivo
Dis Model Mech 3:705-20Kohler RS, Schmitz D, Cornils H, Hemmings BA, Hergovich A (2011) Differential NDR/LATS interactions with the human MOB family reveal a negative role for human MOB2 in the regulation of human NDR kinases
Mol Cell Biol 30:4507-20Cornils H, Stegert MR, Hergovich A, Hynx D, Schmitz D, Dirnhofer S, Hemmings BA (2010) Ablation of the kinase NDR1 predisposes mice to the development of T cell lymphoma
Sci Signal 3:ra47Hergovich A, Hemmings BA (2010) TAZ-mediated crosstalk between Wnt and Hippo signaling
Dev Cell 18(4):508-509Vichalkovski A, Gresko E, Hess D, Restuccia DF, Hemmings BA (2010) PKB/AKT phosphorylation of the transcription factor Twist-1 at Ser42 inhibits p53 activity in response to DNA damage
Oncogene 29:3554-65Bozulic L, Hemmings BA (2009) PIKKing on PKB: regulation of PKB activity by phosphorylation
Curr Opin Cell Biol 21:256-261Grzmil M, Hemmings BA (2009) Deregulated signalling networks in human brain tumours
Biochim Biophys Acta 1804(3):476-483Hergovich A, Hemmings BA (2009) Mammalian NDR/LATS protein kinases in hippo tumor suppressor signaling
Biofactors 35(4):338-45Hergovich A, Kohler RS, Schmitz D, Vichalkovski A, Cornils H, Hemmings BA (2009) The MST1 and hMOB1 tumor suppressors control human centrosome duplication by regulating NDR kinase phosphorylation
Curr Biol 19:1692-702Parcellier A, Tintignac LA, Zhuravleva E, Cron P, Schenk S, Bozulic L, Hemmings BA (2009) Carboxy-Terminal Modulator Protein (CTMP) is a mitochondrial protein that sensitizes cells to apoptosis
Cell Signal 21:639-650Parcellier A, Tintignac LA, Zhuravleva E, Dummler B, Brazil DP, Hynx D, Cron P, Schenk S, Olivieri V, Hemmings BA (2009) The Carboxy-Terminal Modulator Protein (CTMP) regulates mitochondrial dynamics
PLoS ONE. 4:e5471. Epub 2009 May 7Park J, Feng J, Li Y, Hammarsten O, Brazil DP, Hemmings BA (2009) DNA-dependent protein kinase-mediated phosphorylation of protein kinase B requires a specific recognition sequence in the C-terminal hydrophobic motif
J Biol Chem 284:6169-6174Restuccia D, Hemmings BA (2009) Blocking Akt-ivity
Science 325:1083-1084