Jul 26, 2016

Structural insights into HDAC6 activity and inhibition

FMI research groups led by Patrick Matthias and Heinz Gut have elucidated the long-sought crystal structure of the catalytic domains of HDAC6, as well as functionally analyzing this protein. HDAC6 is a key player in the cellular stress response, and its inhibition is considered a promising avenue for the treatment of myelomas and possibly also autoimmune diseases and inflammation. This study should therefore facilitate drug development efforts. In addition, the scientists identified a novel HDAC6 selective inhibitor and clarified how HDAC6 acts on its main physiological substrate tubulin. Read more

Jun 24, 2016

Aggressiveness of acute myeloid leukemia elucidated

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Jun 02, 2016

How fear makes us freeze

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May 27, 2016

Double honors for the Bentires-Alj lab

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Next seminars & events

Aug 02, 2016. Time: 13.00  FMI Room 530  Add to my calendar  Register for this event

Regulatory Roles of Repeat RNA
John L. Rinn, Harvard Department of Stem Cell & Regenerative Biology, Harvard University, Cambridge, MA, USA

Sep 06, 2016. Time: 12.30  FMI Room 530  Add to my calendar  Register for this event

Basel Breast Consortium Tandem Seminar Series
1. Unravelling mechanisms of breast cancer metastasis
2. Ultrasound in breast cancer diagnostics
3. Translation of genomics into actionable information

1. Curzio Rüegg, Pathology, University of Fribourg
2. Rosanna Zanetti, Claraspital, Basel
3. Matthias Langenfeld, Genomic Health International, Geneva

Sep 30, 2016. Time: 10.15  FMI Room 530  Add to my calendar  Register for this event

Epigenetic mechanisms in early mammalian development
Maria Elena Torres-Padilla, Institute of Epigenetics and Stem Cells (IES), Helmholtz Zentrum, Munich, Germany

Oct 04, 2016. Time: 16.00  FMI Room 530  Add to my calendar  Register for this event

Title t.b.a.
Tom Cech, University of Colorado, Boulder, CO, USA

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Recent Publications

Wicki A, Mandalà M, Massi D, Taverna D, Tang H, Hemmings BA, Xue G Acquired Resistance to Clinical Cancer Therapy: A Twist in Physiological Signaling Physiol Rev. 2016 Jul; 96(3):805-29

Eymery A, Liu Z, Ozonov EA, Stadler MB, Peters AH The methyltransferase Setdb1 is essential for meiosis and mitosis in mouse oocytes and early embryos Development. 2016 Jun; [Epub ahead of print]

Ferralli J, Chiquet-Ehrismann R, Degen M KLF4a stimulates breast cancer cell proliferation by acting as a KLF4 antagonist. Oncotarget. 2016 Jun; [Epub ahead of print]

Gonzalez-Sandoval A, Gasser SM On TADs and LADs: Spatial Control Over Gene Expression Trends Genet. 2016 Jun; [Epub ahead of print]

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