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May 02, 2016

Unraveling complex neuronal networks

One of the fundamental questions in neuroscience is how neuronal circuits are wired to process information. The research group led by Rainer Friedrich has developed new methods to determine the complex morphology of densely packed neurons and their synaptic connections by 3D electron microscopy. As reported in Nature Neuroscience, these methods allowed them to reconstruct the entire olfactory bulb of a zebrafish larva, comprising more than 1000 neurons. They found that neuronal projections in the olfactory bulb are widely distributed but not randomly organized. Rather, the network contains modules that receive similar input, which are more likely to be interconnected than others. This study marks a step forward in the emerging field of connectomics. Read more

Apr 25, 2016

Four "ERC Advanced Grants" awarded to FMI group leaders

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Apr 07, 2016

A master regulator serving more than 200 protein degradation machines

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Mar 11, 2016

Marc Bühler awarded prestigious ERC Consolidator Grant

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Next seminars & events

May 11, 2016. Time: 15.00  FMI Room 530  Add to my calendar  Register for this event

Shaping fear circuitry and memory from experience
Wulf Haubensak, Institute of Molecular Pathology (IMP), Vienna, Austria

May 17, 2016. Time: 15.00  FMI Room 530  Add to my calendar  Register for this event

DNA base damage, repair and neurodevelopment
Barbara van Loon, Norwegian University for Science and Technology, Trondheim, Norway

May 19, 2016. Time: 11.30  FMI Room 530  Add to my calendar  Register for this event

Making, breaking and linking memories
Sheena Josselyn, The Hospital for Sick Children (SickKids), Toronto, Canada

May 27, 2016. Time: 12.15  FMI Room 530  Add to my calendar  Register for this event

Dynamic changes in host histone modification and chromatin architecture to influenza virus infection
Yumiko Imai, Akita University Graduate School of Medicine, Akita, Japan

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Recent Publications

Wanner AA, Genoud C, Masudi T, Siksou L, Friedrich RW Dense EM-based reconstruction of the interglomerular projectome in the zebrafish olfactory bulb Nat Neurosci. 2016 Apr; [Epub ahead of print]

Horigome C, Bustard DE, Marcomini I, Delgoshaie N, Tsai-Pflugfelder M, Cobb JA, Gasser SM PolySUMOylation by Siz2 and Mms21 triggers relocation of DNA breaks to nuclear pores through the Slx5/Slx8 STUbL Genes Dev. 2016 Apr; [Epub ahead of print]

Petzold G, Fischer ES, Thomä NH Structural basis of lenalidomide-induced CK1a degradation by the CRL4CRBN ubiquitin ligase Nature. 2016 Apr; 532(7597):127-30

Leroy C, Ramos P, Cornille K, Bonenfant D, Fritsch C, Voshol H, Bentires-Alj M Activation of IGF1R/p110/AKT/mTOR confers resistance to a-specific PI3K inhibition Breast Cancer Res. 2016 Apr; 18(1):41

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