A genome-scale map of DNA methylation kinetics
While the first genome-wide DNA methylation map in mammalian cells was established over 10 years ago, such maps only provide snapshots and do not inform about the actual dynamics of this epigenetic mark. Researchers from the Schübeler group now quantified actual rates of methylation and demethylation for 860,404 individual CpGs in mouse embryonic stem cells. Their study reveals highly variable and context-specific activity for the DNA methylation machinery.
About the FMI
The Friedrich Miescher Institute for Biomedical Research (FMI), based in Basel, Switzerland, is a world-class biomedical research institute, affiliated with the University of Basel and the Novartis Institutes for Biomedical Research.
The FMI turns 50 this year
FMI ranks first in success rates for ERC grant applications
Video: FMI group leader Charisios Tsiairis
Upcoming Seminars & Events
Due to the current coronavirus situation, all live seminars and events at the FMI have been cancelled or postponed.
We will feature content in this section once we will have public events again.
A Genome-Scale Map of DNA Methylation Turnover Identifies Site-Specific Dependencies of DNMT and TET Activity
SUMOylated PRC1 controls histone H3.3 deposition and genome integrity of embryonic heterochromatin.
LSM2-8 and XRN-2 contribute to the silencing of H3K27me3-marked genes through targeted RNA decay.