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Jan 14, 2019

A metabolic checkpoint for embryonic stem cell differentiation

Upon exit from self-renewal, embryonic stem cells differentiate into different types of tissues – a process regulated by various complex mechanisms. Recent work published by the Betschinger group shows the importance of the lysosome – which is directly associated with cellular metabolism and nutrition – in developmental progression. The researchers could also link their findings to a human developmental disorder. Read more

Jan 02, 2019

Pushing the boundaries of the visible

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Dec 17, 2018

How liquid droplets grow in cells

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Dec 05, 2018

Whole-brain imaging of mice during behavior

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Next seminars & events

Jan 29, 2019. Time: 16:30  FMI Room 530  Add to my calendar  Register for this event

Insights into N-glycosylation from cryo-EM studies on the yeast oligosaccharyltransferase complex
Rebekka Wild, Institute of Molecular Biology and Biophysics, ETH Zurich

Jan 31, 2019. Time: 11:30  FMI Room 530  Add to my calendar  Register for this event

Local translation in neuronal dendrites and axons
Erin Schuman, Max Planck Institute for Brain Research, Frankfurt, Germany

Feb 14, 2019. Time: 14:00  FMI Room 530  Add to my calendar  Register for this event

Title t.b.a.
Makoto Saito

Feb 18, 2019. Time: 11:00  FMI Room 530  Add to my calendar  Register for this event

High-resolution cryo-EM studies of protein complexes involved in cell cycle regulation
Andreas Boland, Department of Molecular Biology, University of Geneva

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Recent Publications

Saito M, Hess D, Eglinger J, Fritsch AW, Kreysing M, Weinert BT, Choudhary C, Matthias P Acetylation of intrinsically disordered regions regulates phase separation. Nat Chem Biol. 2019 Jan;15(1):51-61

Villegas F, Lehalle D, Mayer D, Rittirsch M, Stadler MB, Zinner M, Olivieri D, Vabres P, Duplomb-Jego L, De Bont ESJM, Duffourd Y, Duijkers F, Avila M, Geneviève D, Houcinat N, Jouan T, Kuentz P, Lichtenbelt KD, Thauvin-Robinet C, St-Onge J, Thevenon J, van Gassen KLI, van Haelst M, van Koningsbruggen S, Hess D, Smallwood SA, Rivière JB, Faivre L, Betschinger J Lysosomal Signaling Licenses Embryonic Stem Cell Differentiation via Inactivation of Tfe3. Cell Stem Cell. 2018 Dec 23

Macé É, Montaldo G, Trenholm S, Cowan C, Brignall A, Urban A, Roska B Whole-Brain Functional Ultrasound Imaging Reveals Brain Modules for Visuomotor Integration. Neuron. 2018 Dec 5;100(5):1241-1251.e7

Krüttner S, Caroni P m6A-epitranscriptome modulates memory strength. Cell Res. 2018 Dec 4

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