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Jun 10, 2019

New method reveals principles of chromatin folding in vivo

Characterizing chromosome structure is fundamental to a better understanding of gene expression. Current experimental methods helped to build mechanistic models of chromosome folding, however they could not be formally validated so far by independent techniques. This is what the Giorgetti group just did – thanks to a new method they developed to measure chromosome structure quantitatively in living cells. Read more

May 30, 2019

A new mechanism for accessing damaged DNA

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May 22, 2019

A role for gene activators in 3D nuclear organization

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Apr 25, 2019

Intestinal organoid development mimics regeneration

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Next seminars & events

Jun 20, 2019. Time: 11:30  FMI Room 530  Add to my calendar  Register for this event

Maturation of prefrontal circuits in control of cognitive and social behavior
Hirofumi Morishita, Mount Sinai School of Medicine, New York, NY, USA

Jul 04, 2019. Time: 11:30  FMI Room 530  Add to my calendar  Register for this event

Pushing the limits of multiphoton imaging
Chris Xu, Cornell University, Ithaka, NY, USA

Jul 05, 2019. Time: 12:15  FMI Room 530  Add to my calendar  Register for this event

Mechanisms of eukaryotic adaptation
Giulia Rancati, Institute of Medical Biology, Singapore

Jul 08, 2019. Time: 10:00  FMI Room 530  Add to my calendar  Register for this event

How cell fate decisions are maintained by Polycomb Repressive Complexes
Oliver Bell, Keck School of Medicine of the University of Southern California, Los Angeles, USA

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Recent Publications

Fontana GA, Hess D, Reinert JK, Mattarocci S, Falquet B, Klein D, Shore D, Thomä NH, Rass U Rif1 S-acylation mediates DNA double-strand break repair at the inner nuclear membrane. Nat Commun. 2019 Jun 10;10(1):2535

Redolfi J, Zhan Y, Valdes-Quezada C, Kryzhanovska M, Guerreiro I, Iesmantavicius V, Pollex T, Grand RS, Mulugeta E, Kind J, Tiana G, Smallwood SA, de Laat W, Giorgetti L DamC reveals principles of chromatin folding in vivo without crosslinking and ligation. Nat Struct Mol Biol. 2019 Jun;26(6):471-480

Hurst V, Shimada K, Gasser SM Nuclear Actin and Actin-Binding Proteins in DNA Repair. Trends Cell Biol. 2019 Jun;29(6):462-476

Matsumoto S, Cavadini S, Bunker RD, Grand RS, Potenza A, Rabl J, Yamamoto J, Schenk AD, Schübeler D, Iwai S, Sugasawa K, Kurumizaka H, Thomä NH DNA damage detection in nucleosomes involves DNA register shifting. Nature. 2019 May 29

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