Sep 24, 2016

Controlling cell-fate decisions

Rafal Ciosk and his group at the FMI have identified an important link between the Notch signaling pathway and PRC2-mediated gene silencing. They showed that a fine balance between epigenetic silencing and signaling is crucial for cell-fate decisions. While this study has important implications for normal development and tissue homeostasis, it also provides insights into the origin of certain diseases associated with abnormal Notch signaling, such as acute T cell leukemia. Read more

Sep 19, 2016

What you see is not always what you get

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Sep 08, 2016

Cloëtta Prize awarded to Andreas Lüthi

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Jul 26, 2016

Structural insights into HDAC6 activity and inhibition

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Next seminars & events

Sep 29, 2016. Time: 14.30  FMI Room 530  Add to my calendar  Register for this event

microRNAs and gene expression variability
Nils Blüthgen, Charité, Universitätsmedizin, Berlin, Germany

Sep 30, 2016. Time: 10.15  FMI Room 530  Add to my calendar  Register for this event

Epigenetic mechanisms in early mammalian development
Maria Elena Torres-Padilla, Institute of Epigenetics and Stem Cells (IES), Helmholtz Zentrum, Munich, Germany

Oct 03, 2016. Time: 17.00  FMI Room 530  Add to my calendar  Register for this event

Dissecting neural circuits for memory, navigation and attention in the rodent hippocampal formation
Attila Losonczy, Department of Neuroscience, Columbia University Medical Center, New York, USA

Oct 04, 2016. Time: 16.00  FMI Room 530  Add to my calendar  Register for this event

The RNP world: telomerase, epigenetic silencing, and cancer
Tom Cech, University of Colorado, Boulder, CO, USA
More information

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Recent Publications

Nestorov P, Hotz HR, Liu Z, Peters AH Dynamic expression of chromatin modifiers during developmental transitions in mouse preimplantation embryos Sci Rep. 2016 Sep; 5:14347

Miki TS, Carl SH, Stadler MB, Großhans H XRN2 Autoregulation and Control of Polycistronic Gene Expresssion in Caenorhabditis elegans PLoS Genet. 2016 Sep; 12(9):e1006313

Fiser A, Mahringer D, Oyibo HK, Petersen AV, Leinweber M, Keller GB Experience-dependent spatial expectations in mouse visual cortex Nat Neurosci. 2016 Sep; [Epub ahead of print]

Seelk S, Adrian-Kalchhauser I, Hargitai B, Hajduskova M, Gutnik S, Tursun B, Ciosk R Increasing Notch signaling antagonizes PRC2-mediated silencing to promote reprograming of germ cells into neurons Elife. 2016 Sep; [Epub ahead of print]

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