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May 22, 2019

A role for gene activators in 3D nuclear organization

From yeast to man, the genome is partitioned into subnuclear compartments, with active euchromatin spatially separated from silent heterochromatin, which is often found at the nuclear periphery. This spatial distribution correlates with gene expression and contributes to cell-type integrity. In a study published in Nature, the Gasser group showed that the sequestration of a strong gene activator, CBP/p300, regulates the spatial organization of inactive domains. Read more

Apr 25, 2019

Intestinal organoid development mimics regeneration

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Apr 23, 2019

Stressed, anxious? Ask the brain!

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Apr 17, 2019

Making room for genome regulation

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Next seminars & events

May 24, 2019. Time: 12:15  FMI Room 530  Add to my calendar  Register for this event

Roles of histone variant H2A.Z and actin family in chromatin and nuclear organization
Masahiko Harata, Graduate School of Agricultural Science, Tohoku University, Sendai, Japan

Jun 04, 2019. Time: 12:15  FMI Room 530  Add to my calendar  Register for this event

Stem cells in the adult brain: glial identity and niches
Fiona Doetsch, Biozentrum, University of Basel

Jun 04, 2019. Time: 17:00  FMI Room 530  Add to my calendar  Register for this event

All Institutes Career Event
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Jun 05, 2019. Time: 16:00  FMI Room 530  Add to my calendar  Register for this event

Transcription factor interplay regulates ferritin levels to promote cold survival
Tina Pekec

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Recent Publications

Duempelmann L, Mohn F, Shimada Y, Oberti D, Andriollo A, Lochs S, Bühler M Inheritance of a Phenotypically Neutral Epimutation Evokes Gene Silencing in Later Generations. Mol Cell. 2019 May 2;74(3):534-541.e4

Serra D, Mayr U, Boni A, Lukonin I, Rempfler M, Challet Meylan L, Stadler MB, Strnad P, Papasaikas P, Vischi D, Waldt A, Roma G, Liberali P Self-organization and symmetry breaking in intestinal organoid development. Nature. 2019 May;569(7754):66-72

Barisic D, Stadler MB, Iurlaro M, Schübeler D Mammalian ISWI and SWI/SNF selectively mediate binding of distinct transcription factors. Nature. 2019 May;569(7754):136-140

Hohn B From Bacteriophage to Plant Genetics. Annu Rev Plant Biol. 2019 Apr 29;70:1-22

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