We want to understand the molecular mechanisms of health and disease
We train and mentor PhD students and postdocs
We work on biological mechanisms that enable biomedical application
Our 19 research groups
are supported by cutting-edge
technology platforms
Genome Regulation
 Multicellular Systems
 Neurobiology
More News

Latest News

Nov 20, 2024

New tool to map protease specificity may pave the way for improved treatments

FMI researchers have developed a new tool that maps how proteases —enzymes that process proteins— cut their targets. This innovation offers new insight into the highly selective nature of proteases, which were previously seen as indiscriminate degraders. The work could change how we approach drug design, particularly for conditions such as diabetes and obesity, by creating more stable, targeted treatments.

Nov 05, 2024

Rainer Friedrich receives ERC Synergy Grant to study mechanisms of intelligent behavior
Oct 29, 2024

Laure Plantard: A journey through microscopy, mountains and inclusion

About the FMI

The Friedrich Miescher Institute for Biomedical Research (FMI), based in Basel, Switzerland, is a world-class biomedical research institute, affiliated with the University of Basel and the Novartis Institutes for Biomedical Research.

330
People
45
Nationalities
20
Research Groups
15
active ERC grants (and equivalent)

Highlights

Video: Proudly advancing biomedical research and training

Video: How AI can help reveal the workings of the brain
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Upcoming Seminars & Events

Dec 12, 2024 - 16:00 - Fab24 0.60/61

New insights into mRNA translation and associated processes

  Seminar - Juliette Fedry, MRC Lab or Molecular Biology, Cambridge, UK
This is part of the University lecture G5: "Translational control and post-translational protein modification"
Register for Event Save to Calendar
Dec 19, 2024 - 10:00 - Fab24 0.60/61

Function and organization of an autoassociative olfactory memory network

  Thesis Presentation - Bo Hu
Register for Event Save to Calendar
Jan 17, 2025 - 11:00 - Fab24 0.60/61

YISS Seminar
title tbd.

  Young Investigator Seminar Series - Joris van der Veeken
Research Institute of Molecular Pathology, Vienna
Register for Event Save to Calendar
More Publications

Latest Publications

Nov 15, 2024

Loss of cytoplasmic actin filaments raises nuclear actin levels to drive INO80C-dependent chromosome fragmentation.

Hurst V, Gerhold CB, Tarashev CVD, Challa K, Seeber A, Yamazaki S, Knapp B, Helliwell SB, Bodenmiller B, Harata M, Shimada K, Gasser SM

Nat Commun
Nov 15, 2024

TORC2 inhibition triggers yeast chromosome fragmentation through misregulated Base Excision Repair of clustered oxidation events.

Shimada K, Tarashev CVD, Bregenhorn S, Gerhold CB, van Loon B, Roth G, Hurst V, Jiricny J, Helliwell SB, Gasser SM

Nat Commun
Nov 14, 2024

The human gestational sac as a choriovitelline placenta during early pregnancy; the secondary yolk sac and organoid models.

Burton GJ, Jauniaux E, Cindrova-Davies T, Turco MY

Dev Biol
Oct 28, 2024

Deep quantification of substrate turnover defines protease subsite cooperativity.

Gudipati RK, Gaidatzis D, Seebacher J, Muehlhaeusser S, Kempf G, Cavadini S, Hess D, Soneson C, Großhans H

Mol Syst Biol

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