We want to understand
the molecular mechanisms
of health and disease
We train and mentor
PhD students
and postdocs
We work on biological
mechanisms that enable
biomedical application
Our 22 research groups
are supported
by cutting-edge
technology platforms
Epigenetics
 Quantitative Biology
 Neurobiology
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Latest News

Jan 14, 2021

Protecting the genome from transposon activation

Transposons are foreign DNA elements capable of random insertion into the genome, an event that can be very dangerous for a cell. Their activity must be silenced to maintain genomic integrity, which is primarily achieved by H3K9me3-mediated repression. Researchers from the Gasser group identified two parallel pathways that are essential for H3K9me3- mediated transcriptional repression and thus for protecting the genome from toxic transposon activation.

Jan 06, 2021

Neuronal circuits for fine motor skills
Dec 23, 2020

Did you know? 10 facts about the FMI

About the FMI

The Friedrich Miescher Institute for Biomedical Research (FMI), based in Basel, Switzerland, is a world-class biomedical research institute, affiliated with the University of Basel and the Novartis Institutes for Biomedical Research.

340
People
43
Nationalities
21
Research Groups
131
Publications in 2019

Highlights

Winning image of our 2020 Christmas Card competition:
C. elegans snowflakes

Video and article: How to identify new molecular glue degrader drugs

Group leader video: Marc Bühler
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Upcoming Seminars & Events

Jan 25, 2021 - 13:00

The role of chromatin loop extrusion in generating a diverse antibody repertoire

  Seminar - Meinrad Busslinger, IMP Research Institute of Molecular Pathology, Vienna, Austria
Join by Zoom:
https://fmi.zoom.us/j/95596151350?pwd=MVFxNUp2Mmt3SVdTY0tCZTdoNHljQT09
Meeting ID: 955 9615 1350
Passcode: 849597
Register for Event Save to Calendar
Jan 28, 2021 - 10:00-12:30

Organoid Symposium: Design principles of multicellular systems

  Other - Organized by FMI and D-BSSE
Registration is free but mandatory
Please register here: https://forms.gle/MwuSMGHgZ7tvpWNM9
» See poster
Register for Event Save to Calendar
Feb 16, 2021 -

Computational Neuroscience Initiative Basel
Human decision bias and variability from cognitive limitations

  Seminar - Rava da Silveira, IOB Basel and ENS Paris
For additional information, please visit our website: www.fmi.ch/CNIB
Register for Event Save to Calendar
More Publications

Latest Publications

Jan 21, 2021

Dynamic association of human Ebp1 with the ribosome.

Bhaskar V, Desogus J, Graff-Meyer A, Schenk AD, Cavadini S, Chao JA

RNA
Jan 11, 2021

Preprocessing choices affect RNA velocity results for droplet scRNA-seq data.

Soneson C, Srivastava A, Patro R, Stadler MB

PLoS Comput Biol
Jan 6, 2021

A functional map for diverse forelimb actions within brainstem circuitry.

Ruder L, Schina R, Kanodia H, Valencia-Garcia S, Pivetta C, Arber S

Nature
Jan 01, 2021

Argonaute NRDE-3 and MBT domain protein LIN-61 redundantly recruit an H3K9me3 HMT to prevent embryonic lethality and transposon expression.

Padeken J, Methot S, Zeller P, Delaney CE, Kalck V, Gasser SM

Genes Dev

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