A developmental clock with a checkpoint function
The group of Helge Grosshans characterized the "C. elegans oscillator", over 3,700 genes that are rhythmically expressed during the larval development of C. elegans. They demonstrated the coupling of the oscillator with molting and got insights into how it is wired. Their findings suggest that the oscillator functions as a developmental clock with a developmental checkpoint function.
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The Friedrich Miescher Institute for Biomedical Research (FMI), based in Basel, Switzerland, is a world-class biomedical research institute, affiliated with the University of Basel and the Novartis Institutes for Biomedical Research.
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Developmental function and state transitions of a gene expression oscillator in Caenorhabditis elegans