Histone degradation after DNA damage enhances repair
DNA damage can occur anywhere in the genome, but most DNA is wrapped around nucleosomes making it inaccessible to the repair machinery. Researchers from the Gasser group now show that DNA damage induces histone depletion, which increases the accessibility and flexibility of the DNA fiber and enhances the rate of homology search during repair by homologous recombination.
About the FMI
The Friedrich Miescher Institute for Biomedical Research (FMI), based in Basel, Switzerland, is a world-class biomedical research institute, affiliated with the University of Basel and the Novartis Institutes for Biomedical Research.
The FMI turns 50 this year
FMI ranks first in success rates for ERC grant applications
Apply to our PhD and MD-PhD Programs
Upcoming Seminars & Events
Due to the current coronavirus situation, all live seminars and events at the FMI have been cancelled or postponed.
We will feature content in this section once we will have public events again.
Design principles of tissue organisation: How single cells coordinate across scales.