Foreign vs. own DNA: How an innate immune sensor tells friend from foe
How do molecules involved in activating our immune system discriminate between our own DNA and foreign pathogens? Researchers from the Thomä group, in collaboration with the EPFL, deciphered the structural and functional basis of a DNA-sensing molecule when it comes in contact with the cell’s own DNA, providing crucial insights into the recognition of self vs. non-self DNA.
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The Friedrich Miescher Institute for Biomedical Research (FMI), based in Basel, Switzerland, is a world-class biomedical research institute, affiliated with the University of Basel and the Novartis Institutes for Biomedical Research.
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Monitoring Acetylation of the RNA Helicase DDX3X, a Protein Critical for Formation of Stress Granules.
Opposing Influence of Top-down and Bottom-up Input on Excitatory Layer 2/3 Neurons in Mouse Primary Visual Cortex.
DNA Damage-Induced Nucleosome Depletion Enhances Homology Search Independently of Local Break Movement.