The circuitous path to adulthood
Genes that time the transition to adulthood are well-studied in the roundworm C. elegans, and at least partially conserved in mammals, where they regulate the onset of puberty. Juvenile worms turn into adults when a protein called LIN-29 accumulates in sufficient amounts. By studying two variants of LIN-29, the group of Helge Grosshans reveals that temporal coordination of events during the transition to adulthood involves a branched pathway rather than a linear chain of events.... Read more
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What can microscopic aquatic creatures teach us about growing new body parts?
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A branched heterochronic pathway directs juvenile-to-adult transition through two LIN-29 isoforms.
Loss of an H3K9me anchor rescues laminopathy-linked changes in nuclear organization and muscle function in an Emery-Dreifuss muscular dystrophy model.
A virtual reality system to analyze neural activity and behavior in adult zebrafish.