We want to understand

the molecular mechanisms

of health and disease

We train and mentor

PhD students

and postdocs

We work on biological

mechanisms that enable

biomedical application

Our 22 research groups

are supported

by cutting-edge

technology platforms

Epigenetics
Quantitative Biology
Neurobiology

More News

Latest News

Sep 24, 2020

Histone degradation after DNA damage enhances repair

DNA damage can occur anywhere in the genome, but most DNA is wrapped around nucleosomes making it inaccessible to the repair machinery. Researchers from the Gasser group now show that DNA damage induces histone depletion, which increases the accessibility and flexibility of the DNA fiber and enhances the rate of homology search during repair by homologous recombination.

Sep 21, 2020

How to make a replication origin in multicellular eukaryotes

Sep 14, 2020

Congratulations to the winners of the FMI science prizes 2020

About the FMI

The Friedrich Miescher Institute for Biomedical Research (FMI), based in Basel, Switzerland, is a world-class biomedical research institute, affiliated with the University of Basel and the Novartis Institutes for Biomedical Research.

340

People

Nationalities

Research Groups

131

Publications in 2019

Highlights

The FMI turns 50 this year

FMI ranks first in success rates for ERC grant applications

Apply to our PhD and MD-PhD Programs

Upcoming Seminars & Events

Due to the current coronavirus situation, all live seminars and events at the FMI have been cancelled or postponed.
We will feature content in this section once we will have public events again.

More Publications

Latest Publications

Sep 17, 2020

Cell Types of the Human Retina and Its Organoids at Single-Cell Resolution.

Cowan CS, Renner M, De Gennaro M, Gross-Scherf B, Goldblum D, Hou Y, Munz M, Rodrigues TM, Krol J, Szikra T, Cuttat R, Waldt A, Papasaikas P, Diggelmann R, Patino-Alvarez CP, Galliker P, Spirig SE, Pavlinic D, Gerber-Hollbach N, Schuierer S, Srdanovic A, Balogh M, Panero R, Kusnyerik A, Szabo A, Stadler MB, Orgül S, Picelli S, Hasler PW, Hierlemann A, Scholl HPN, Roma G, Nigsch F, Roska B

Cell

Sep 10, 2020

Structural mechanism of cGAS inhibition by the nucleosome.

Pathare GR, Decout A, Glück S, Cavadini S, Makasheva K, Hovius R, Kempf G, Weiss J, Kozicka Z, Guey B, Melenec P, Fierz B, Thomä NH, Ablasser A

Nature

Sep 01, 2020

Design principles of tissue organisation: How single cells coordinate across scales.

Zinner M, Lukonin I, Liberali P

Curr Opin Cell Biol

Jul 25, 2020

ExploreModelMatrix: Interactive exploration for improved understanding of design matrices and linear models in R.

Soneson C, Marini F, Geier F, Love MI, Stadler MB