FMI News Archive
What it is like to be a researcher
Over 200 high school students visited the FMI to learn more about biomedical research and the everyday life of a researcher. The goal of the event was to help the student better understand what it really means to work in research so that they can take more informed decisions abou...
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Thwarting cellular enzyme can fight viral infections
FMI researchers have identified a synthetic protein that dampens the activity of a cellular pathway involved in viral infection. The findings could help to develop drugs that combat viruses such as influenza A and Zika....
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Nicolas Thomä receives the Otto Naegeli Prize 2022
Nicolas Thomä, a research group leader at the Friedrich Miescher Institute for Biomedical Research (FMI) in Basel, receives the Otto Naegeli Prize for Medical Research, one of the most prestigious scientific awards in Switzerland. Thomä is recognized for his groundbreak...
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Structural insights into the assembly of cilia
Cilia, the little “hairs” attached to almost all cells of the human body, play a role in various cellular functions and cause diseases called ciliopathies when they are defective. Researchers from the group of Patrick Matthias and the FMI Structural Biology platform d...
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Enhancer-promoter interactions — distance matters
When and where a gene is transcribed in a living organism often depends on its physical interactions with distal genomic regulatory regions called enhancers. Researchers in the group of Luca Giorgetti have thrown light on how such interactions control transcription thanks to a no...
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Enlightening the brain’s circuitry
For nearly 50 years FMI Neurobiology has played a crucial role in shedding light on neuronal circuits that program how we behave, learn, and remember. In particular, neurobiologists at the FMI contributed – and are still contributing – to providing answers to a fundam...
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Community-based initiative improves reproducibility in microscopy and imaging
Researchers from the FMI Facility for Advanced Imaging and Microscopy (FAIM) are drivers of a large-scale international initiative dedicated to improving quality assessment and quality control in light microscopy. Recently, the workgroup chaired by the Head of FAIM delivered the ...
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Brain Prize 2022 for Silvia Arber
Silvia Arber from the FMI and the Biozentrum, University of Basel receives the Brain Prize 2022, the world’s largest neuroscience Prize. With this award, the Lundbeck Foundation recognizes this year's three prize winners for their pioneering research into the neuronal circu...
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Familiar objects can prevent autism-like behaviors in mouse model
The emergence of autism traits can result from different factors, such as a person’s environment and genetic background. FMI researchers and their Novartis collaborators showed that exposing mice with an autism mutation to a new environment can trigger autism-like behaviors...
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A "resolution revolution": how cryo-EM accelerates biomedicine and drug discovery
Cryo-electron microscopy, or cryo-EM for short, has revolutionized the way scientists image the smallest of structures. In a short video, the heads of the joint Novartis-FMI cryo-EM center discuss how the technique is advancing biomedical research and drug discovery, and where th...
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Spotlight on FMIers: Gisèle Ferrand
To discover the molecular mechanisms of health and disease, some FMI researchers use animals such as mice and fish. This animal research will help to understand the causes of conditions including cancer, Parkinson’s disease and psychiatric disorders, paving the way to new d...
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Congratulations to our fellowship winners
Three FMI postdoctoral researchers were among the recipients of the prestigious EMBO postdoctoral fellowships, autumn 2021 selection. In addition, an FMI student was recently awarded a Boehringer Ingelheim Fonds (BIF) fellowship. Read on to learn more about these researchers and ...
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The neuronal mechanism behind motivation
Our actions are motivated by the goals we want to achieve. However, little is known about the mechanism in our brains that allow us to make the right decisions to reach our goals. Researchers in the Lüthi lab now identified the sequence of events taking place in a mouse brai...
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How neurons that wire together fire together
For amplifying sensory stimuli quickly and accurately, neuronal circuits require specific wiring. Some 70 years ago, the compelling idea that “neurons that fire together wire together” emerged. Yet, in computational models, neurons that wire together tend to succumb t...
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Mechanical forces shape the ‘immortal’ Hydra
Hydras are tiny creatures with regenerative superpowers: they can renew their stem cells and replace damaged body parts in only a few days. Now, researchers in the Tsiairis group have found that mechanical forces turn on key genes as the mighty Hydras regenerate their entire bodi...
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How sound changes sight
When we learn to associate an auditory stimulus with a visual stimulus, the perception of that visual stimulus changes, but this phenomenon is not well understood. For the first time, the Keller group has now identified a mechanism in the brain that enables auditory information t...
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Uterine atlas can lead to better models of the womb, provide insights into diseases
In the quest to study the womb and its role in reproductive health, researchers in the Turco lab and their collaborators have generated a cellular map of the human uterus and of endometrial organoids — lab-grown models of the womb’s lining. The atlas, which is the mos...
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Studying the understudied in human biology: a chat with Margherita Yayoi Turco
Margherita Yayoi Turco is FMI’s newest group leader, leading a team of researchers who will investigate how the placenta develops and works together with the mother’s uterus during early pregnancy. She talks about her fascination with conservation biology, why 3D clus...
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Eccellenza Fellowship for Friedemann Zenke
FMI group leader Friedemann Zenke receives an Eccellenza Professorial Fellowship from the Swiss National Science Foundation (SNSF). These recognitions are awarded yearly to outstanding independent researchers who aspire to a permanent professorship....
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Susan Gasser receives honorary doctorate from the University of Fribourg
Susan Gasser, former FMI director and professor emeritus of molecular biology at the University of Basel, has been awarded an honorary doctorate by the University of Fribourg....
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A histone modification essential for tissue integrity
Chemical modifications of histones, the small proteins around which DNA is wrapped, are known to affect gene expression. In a study conducted in C. elegans, researchers from the Gasser group show that the defining modification of the tightly packed form of DNA called het...
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Mini-placentas: promising tools for studying early pregnancy and its complications
Despite its crucial role in healthy pregnancies, the placenta is one of the least understood organs in the human body. In a new study, Margherita Yayoi Turco and her colleagues compared the two main experimental models of the human placenta. The findings suggest that 3D clusters ...
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Congratulations to the winners of the FMI Science Prizes 2021
Our three internal FMI Science Prizes were awarded last week during our Annual Meeting, which took place at the FMI this year. The Ed Fischer Prize, the Max Burger Prize and the Ruth Chiquet Prize recognize respectively the best thesis, the best postdoc study, and an innovative n...
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FMI research areas
Research themes at the FMI evolve, reflecting our scientific interests and goals. Following an internal review of our strengths and the definition of the most pressing biomedical questions that we aim to address, we have decided to evolve our research areas into: Genome Regulatio...
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Research grant for Silvia Arber to investigate Parkinson's
Silvia Arber — group leader at the FMI and at the Biozentrum, University of Basel — and a team of international experts receive 8 million Swiss Francs from the Aligning Science Across Parkinson's (ASAP) initiative to investigate Parkinson's. The aim is to uncover how ...
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Worm atlas could help crack mysteries in animal evolution
Researchers in the Friedrich group have contributed to create an atlas that links subcellular structures to gene expression in each cell of the sea worm Platynereis dumerilii, a key model organism for the study of development and evolution. The atlas will help researcher...
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Charlotte Soneson wins Bioconductor Award 2021
Charlotte Soneson, a member of the FMI Computational Biology platform, has been awarded the Bioconductor Award 2021 that recognizes outstanding contributions to the Bioconductor project and community. The Bioconductor project is one of the major software collections for bioinform...
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Spotlight on FMIers: Marco Pregnolato
Spotlight on FMIers showcases the lives, work and passions of the institute’s researchers and support staff. This time, PhD student Marco Pregnolato tells us about his efforts to communicate science to the public and his dream of making a short film about climate change.
From imaging neurons to measuring their true activity
Neuroscientists often use calcium imaging to analyze neuronal activity in the intact brain. But this method provides only an indirect and slow measure of action potential firing, creating the need to reliably reconstruct action potentials from calcium signals. Peter Rupprecht, a ...
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More than just walking: a new role for core brain region
For decades, a key brain area called the mesencephalic locomotor region has been thought to merely regulate locomotion. Now, researchers in Silvia Arber’s group have shown that the region is involved in much more than walking, as it contains distinct populations of neurons ...
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Homing in on how cells keep gene silencing in check
Long considered ‘junk’, non-coding RNAs have emerged as important regulators of diverse cellular processes, including the silencing of genes. Working in yeast, researchers from the Bühler group have identified more than 20 mutations that enable RNA-mediated gene ...
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Researchers identify missing ‘switch’ that controls essential genes
Proteins known as transcription factors act as switches that regulate the expression of nearby genes, but the identity of some of these genetic levers has so far remained mysterious. Now, researchers from the Schübeler group have pinpointed a new switch that regulates essent...
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Pico Caroni awarded 2021 Science Prize of the city of Basel
The governing council of Basel awarded this year's Science Prize of the city of Basel to Prof. Dr. Pico Caroni. The neurobiologist, who is a group leader at the FMI and professor of neurobiology at the University of Basel, is being honored for his life's work in basic neuroscienc...
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How proteins bind “hidden” DNA
How can proteins bind DNA in the cell nucleus, where it is present in form of chromatin, tightly wrapped around histones and therefore mostly inaccessible? Recently, several studies began to uncover the various strategies used by DNA-binding proteins to solve this problem. In a C...
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Mini-guts reveal crucial forces that shape the intestinal lining
Using miniature guts grown in a dish and 3D biophysical modelling, FMI researchers and their collaborators have uncovered the forces that give the intestinal wall its classic brushlike appearance. The findings can help to understand how the gut takes form during development &mdas...
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"Mentor matching" helps new PhD students get started during the pandemic
Starting a PhD can be daunting, especially during a pandemic, when uncertainty and social isolation can cause some extra emotional and logistical upheavals. That’s why the FMI launched a ‘mentor matching’ initiative. By pairing senior PhD students with students ...
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‘Tug of war’ between neurons tells the brain when to fear — and when not to be afraid
Fear protects us by making us alert to danger, but the persistence of fearful memories can lead to serious mental conditions. Now, an international team of researchers co-led by Andreas Lüthi has found that the activity of different cells in the brain’s threat-detector...
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Spotlight on FMIers: Gergely Tihanyi
Spotlight on FMIers showcases the lives, work and passions of the institute’s researchers and support staff. This time, graduate student Gergely Tihanyi tells us about his love for food and cooking, and he shares his insights on the FMI Master Chef series — virtual ev...
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In remembrance of Andrew Matus
It is with great sadness that we learned that Andrew Matus passed away on April 26 after a short illness, at the age of 79. Andrew was a group leader at the FMI for nearly 30 years and Titular Professor at the University of Basel. He made pioneering contributions to the field of ...
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ERC Advanced Grant for Silvia Arber
This year’s recipients of the prestigious Advanced Grants from the European Research Council (ERC) have been announced today. The neurobiologist Prof. Silvia Arber, research group leader at the Friedrich Miescher Institute and the Biozentrum of the University of Basel, is a...
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The architect of genome folding
The spatial organization of the genome is fundamental for the regulation of our genes and has to be established de novo during early embryogenesis. By combining powerful Drosophila genetics with 3D chromosome modelling, a collaboration between the Giorgetti group at the ...
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When two worlds meet: a protease that controls small RNA activity
The protection of genome integrity of germ cells is essential for animal fertility. Researchers from the Grosshans group characterized a defense mechanism against selfish genetic elements in the C. elegans germline. They identified a protein processing mechanism that con...
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Congratulations to our fellowship winners
We are pleased to announce the latest FMI winners of prestigious research fellowships, including EMBO, Maria Sklodowska-Curie Actions (MSCA), Human Frontier Science Program (HFSP) and Boehringer Ingelheim Funds (BIF). These grants, targeted at postdocs (and students for BIF), are...
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Spotlight on FMIers: Esther Griesbach
Spotlight on FMIers is a new series that showcases the lives, work and passions of the institute’s researchers and support staff. In the first interview of the series, Esther Griesbach, a postdoctoral fellow in the group of Jeffrey Chao, tells us about herself, the fascinat...
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'Brain state' behind social interaction uncovered
The brain’s emotion-processing center — the amygdala — is one of several brain regions involved in social behavior. But the exact role that this almond-shaped structure plays in the so-called ‘social brain’ remains mysterious. Now, the Lüthi gro...
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New-found molecular signature keeps key genes ready for action
During development, scores of molecular signals prod cells to take on specialized identities and functions. In response to some of these signals, the cellular machinery awakens specific genes called ‘immediate early genes’ within minutes. The Rijli group has now ident...
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Extensive remodeling of chromatin after DNA damage
In eukaryotes, histones are often modified and evicted at site of DNA double-strand breaks in order to facilitate end-resection and break repair. Together with the protein analysis facility of the FMI, the Gasser group has quantified massive changes in the chromatin associated pr...
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Chromatin remodelers never rest to keep our genome open
Chromatin remodelers are needed to take nucleosomes away from DNA in order to make room for transcription factors to bind, and regulate the activity of our genes. It has been unclear how dynamic this process is. Researchers from the Schübeler group now revealed that active r...
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A key regulator for humoral immunity and B lymphoma
The generation of antibodies in B-cells takes place in a dynamic structure that forms during infections, the germinal center (GC). The formation of GCs lays at the heart of the immune response; this process is highly regulated and not fully understood yet. The Matthias group now ...
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Susan Gasser elected director of the ISREC Foundation
FMI Director Emeritus and Group Leader Emeritus, Susan Gasser, has been elected director of the Foundation of the Swiss Institute for Experimental Cancer (ISREC) by the Foundation Council. The ISREC Foundation has contributed to significant discoveries in oncology, and actively a...
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Prisca Liberali awarded prestigious Friedrich Miescher Award
FMI group leader Prisca Liberali, who is also a Professor at the University of Basel, receives the Friedrich Miescher Award 2021 for her research on design principles of tissue organization. The Friedrich Miescher Award is awarded yearly to a young scientist based in Switzerland ...
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Protecting the genome from transposon activation
Transposons are foreign DNA elements capable of random insertion into the genome, an event that can be very dangerous for a cell. Their activity must be silenced to maintain genomic integrity, which is primarily achieved by H3K9me3-mediated repression. Researchers from the Gasser...
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Neuronal circuits for fine motor skills
Writing, driving a screw or throwing darts are only some of the activities that demand a high level of skill. How the brain masters such exquisite movements has now been described in Nature by the group of Silvia Arber. The researchers revealed the existence of a map of brainstem...
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Did you know? 10 facts about the FMI
Throughout 2020, we celebrated the 50th Anniversary of the FMI across our social media channels with a series of ‘Did you know?’ facts about our history. The highlights detail our founding, major achievements, and the key turning points in the evolution of the scienti...
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Thinking afresh about how cells respond to stress
Just like people, cells get stressed too. A sudden drop in oxygen, overheating, or toxins can trigger a cascade of molecular changes that lead cells to stop growing, produce stress-protective factors, and form stress granules – proteins and RNA molecules huddled together in...
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Interview with Susan Gasser, FMI Director Emeritus
Susan Gasser is a world-leading scientist in the field of genome biology and has been involved in guiding science policy and institutes across Europe. She was the FMI Director for 15 years, from 2004 until 2019. Still a group leader at the FMI, she will close her lab at the end ...
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Foreign vs. own DNA: How an innate immune sensor tells friend from foe
How do molecules involved in activating our immune system discriminate between our own DNA and foreign pathogens? Researchers from the Thomä group, in collaboration with the EPFL, deciphered the structural and functional basis of a DNA-sensing molecule when it comes in conta...
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Building artificial neural networks inspired by the brain
The requirements of real biological neural networks are modest compared to the complex deep neural networks used in machine learning, which come with substantial memory and energy demands. The Zenke group has developed a new method in machine learning called Neural Tangent Transf...
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How the visual cortex combines movement and vision
The Keller group had previously shown that the coupling of sensory and motor experience was critical for normal sensorimotor processing. The researchers have now identified the particular subset of cortical neurons responsible for computing mismatches between what we expect to se...
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Intestinal regeneration: lessons from organoid research
Intestinal organoids recapitulate not only the structure of intestinal epithelium but also its ability to regenerate following damage. Using this research tool, the group of Prisca Liberali unraveled mechanisms orchestrating organoid formation and intestinal regeneration with a u...
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Histone degradation after DNA damage enhances repair
DNA damage can occur anywhere in the genome, but most DNA is wrapped around nucleosomes making it inaccessible to the repair machinery. Researchers from the Gasser group now show that DNA damage induces histone depletion, which increases the accessibility and flexibility of the D...
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How to make a replication origin in multicellular eukaryotes
Loading of replicative helicases onto DNA is a key event during the initiation of chromosomal DNA replication. It takes place at specific chromosomal regions termed origins and is facilitated by the ORC protein complex. By resolving the cryo-EM structures of DNA-bound ORC, resear...
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Congratulations to the winners of the FMI science prizes 2020
Due the covid-19 situation, we could not hold our FMI 50th Anniversary Symposium as planned. Instead, we organized a video conference - for FMI members and our Scientific Advisory Board - to celebrate science virtually. The Award ceremonies for our three annual science prizes wer...
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LifeTime - Researchers partner to improve European healthcare
The FMI is a partner of the pan-European LifeTime initiative. In two publications, researchers involved with the initiative - including FMI group leader Susan Gasser - present a detailed roadmap of how to leverage the latest scientific breakthroughs and technologies over the next...
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How to identify new molecular glue degraders
Molecular glue degraders are a new class of drugs that work by facilitating an interaction between a disease-causing target protein and a ubiquitin ligase complex, tagging the target protein for degradation. In this new video, members of the Thomä group, in collaboration wit...
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ERC Starting Grant for Johannes Felsenberg
FMI group leader Johannes Felsenberg is among this year's recipients of a prestigious Starting Grant from the European Research Council (ERC). He will use the grant to study the neural processes that allow memories to be changed, using the fruit fly Drosophila as a model organism...
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FMI is a partner in the new EU “HCA|Organoid” project
The EU research project “HCA (Human Cell Atlas)|Organoid” was launched today. It aims at validating organoids as faithful models of human biology, combining single-cell profiling and organoid technology. Towards this goal, Europe’s leading organoid researchers a...
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A developmental clock with a checkpoint function
The group of Helge Grosshans characterized the "C. elegans oscillator", over 3,700 genes that are rhythmically expressed during the larval development of C. elegans. They demonstrated the coupling of the oscillator with molting and got insights into how it is wi...
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Structural insights into Fe-S protein biogenesis
The cytosolic iron sulfur assembly (CIA) pathway is required for the insertion of Fe-S clusters into proteins, including many DNA replication and repair factors. Despite its essential cellular function, this pathway remains enigmatic. A new integrative structural and biochemical ...
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Building corticocerebellar neural circuits
In a comprehensive study, researchers from the Rijli group found that a single Hox transcription factor expressed in a group of neurons of the pontine nucleus - the cerebral cortex most important brainstem relay to the cerebellum - determines the wiring onto these neurons of spec...
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How transcription factors recognize binding motifs on chromatin
In a video (5’35’’) combining interviews and figures, the team behind the latest collaboration from the Thomä and Schübeler labs - Alicia Michael, Ralph Grand and Luke Isbel - explain how they developed an assay identifying where the preferable sites f...
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A genome-scale map of DNA methylation kinetics
While the first genome-wide DNA methylation map in mammalian cells was established over 10 years ago, such maps only provide snapshots and do not inform about the actual dynamics of this epigenetic mark. Researchers from the Schübeler group now quantified actual rates of met...
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A novel pathway ensuring chromosome stability in early mice embryo
The Peters group studies chromatin formation and regulation in mammalian germ cells and during early embryonic development. Now researchers from the group identified a novel pathway that is essential for maintaining the integrity of heterochromatin, and therefore for securing chr...
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Silvia Arber elected to the American National Academy of Sciences
FMI group leader Silvia Arber is among the 26 international members elected to the National Academy of Sciences (NAS) this year. Members are elected to the NAS in recognition of their distinguished and continuing achievements in original research. Membership is a widely accepted ...
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RNA degradation contributes to heterochromatic gene silencing in higher eukaryotes
The Gasser group discovered that silencing of heterochromatic regions - and more specifically of hundreds of Polycomb-target genes enriched for H3K27me3 - can occur through selective RNA degradation, and not only through transcriptional repression. The study links the epigenetics...
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