Susan M. Gasser

Group News

Feb 16, 2021
Extensive remodeling of chromatin after DNA damage
Feb 9, 2021
Interview Susan M. Gasser – Director Emeritus & Group Leader, FMI
Jan 14, 2021
Protecting the genome from transposon activation
Dec 7, 2020
Interview with Susan Gasser, FMI Director Emeritus
Oct 5, 2020
Interview Susan Gasser
All group news

Resources

Group Website
Video portrait (Inserm Prize 2011)
Susan Gasser CV

Susan M. Gasser

Genome organization during differentiation and stress

The Gasser lab has closed at the end of June 2021.
Susan Gasser moved to the ISREC Foundation in Lausanne.


The Gasser laboratory studies how chromatin, a complex of proteins and nucleic acids, impinges on mechanisms of DNA repair and replication, and on the epigenetic inheritance of cell fate decisions. We use high throughput time-lapse imaging to address questions of chromatin folding in living organisms. With respect to stem cell determination and epigenetic inheritance, we exploit the nematode C. elegans to study the effects of 3D chromatin organization during organismal development. We examine how the environment alters that program and we ask if these changes are epigenetically inherited from one stage of life to another. With respect to the mechanisms of repair, the budding yeast, S. cerevisiae provides a flexible genetic system that allows us to model DNA folding based on the spatial dynamics of chromosomal loci.

Specific areas of focus include:
1. Nuclear subcompartments: Transient long-range interactions within active, or potentially active, chromatin (TADs) and the more stable "condensates" of heterochromatin (LADs) drive chromatin organization in the nucleus. We use genetics to identify factors that spatially segregate large chromatin domains.
2. Chromatin dynamics in repair: Chromatin organization both protects from DNA damage and facilitates repair. We focus on dynamic changes in chromatin during repair and on the role of chromatin compaction in repeat stability.
3. Stress-induced epigenetic function: We are examining whether there is a "memory" function mediated by histone post-translational modifications that controls a stress response, enhancing organismal survival. These studies have a direct impact on the treatment of medical conditions.

Challa, K., Seebacher, J. and Gasser, S.M. (2021) Sucrose gradient chromatin enrichment for quantitative proteomic analysis in budding yeast

STAR protocols, doi: 10.1016/j.xpro.2021.100825, in press.

Saitoh, N. and Gasser, S.M. (2021) Nadeshiko revisited: The situation of women in Japanese research and the measures taken to increase their representation

EMBO Reports. 22, e52528. dx.doi.org/10.15252/embr.202152528.

Fuchs J., Cheblal A., Gasser S.M. (2021) Underappreciated Roles of DNA Polymerase δ in Replication Stress Survival

Trends Genet. 37, 476 - 487. doi: 10.1016/j.tig.2020.12.003.

Hurst, V., Shimada, K. and Gasser, S.M. (2019) Nuclear actin and actin binding proteins in DNA repair

Trends Cell Biol. 29, 462 - 476. doi: 10.1016/j.tcb.2019.02.010.

Hurst, V., Challa, K., Jonas, F., Forey, R., Sack, R., Seebacher, J., Schmid, C.E., Barkai, N., Shimada*, K., Gasser*, S.M. and Poli*, J. (2021) A regulatory phosphorylation site on Mec1 controls chromatin occupancy of RNA polymerases during replication stress

EMBO J. doi: 10.15252/embj.2021108439. in press
*co-corresponding

Shimada. K., van Loon, B., Gerhold, C.B., Bregenhorn, S., Hurst, V., Roth, G., Tarashev, C., Heinis, C., Jiricny, J. and Gasser, S.M. (2021) Uncoordinated long-patch base excision repair at juxtaposed DNA lesions generates a lethal accumulation of double-strand breaks

Nature Comms in revision, and BioRXiv doi: 10.1101/ 2020.11.15.383513

Shimada, K., Tsai-Pflugfelder, M., Davoodi Vijeh Motlagh, N., Delgoshaie, N., Fuchs, J., Gut, H. and Gasser, S.M. (2021) The Stabilized Pol31-Pol3 interface counteracts Pol32 ablation with differential effects on repair.

Life Sci Alliance. 4(9): e202101138. doi: 10.26508/lsa.202101138.

Challa K, Schmid CD, Kitagawa S, Cheblal A, Iesmantavicius V, Seeber A, Amitai A, Seebacher J, Hauer MH, Shimada K, Gasser SM (2021) Damage-induced chromatome dynamics link Ubiquitin ligase and proteasome recruitment to histone loss and efficient DNA repair.

Molecular Cell, 81, 811 - 829. doi: 10.1016/j.molcel.2020.12.021.

Padeken J, Methot S, Zeller P, Delaney CE, Kalck V, Gasser SM (2021) Argonaute NRDE-3 and MBT domain protein LIN-61 redundantly recruit an H3K9me3 HMT to prevent embryonic lethality and transposon expression.

Genes & Dev. 35, 82 - 101. doi: 10.1101/gad.344234.120.

Forey R, Barthe A, Tittel-Elmer M, Wery M, Barrault MB, Ducrot C, Seeber A, Krietenstein N, Szachnowski U, Skrzypczak M, Ginalski K, Rowicka M, Cobb JA, Rando OJ, Soutourina J, Werner M, Dubrana K, Gasser SM, Morillon A, Pasero P, Lengronne A, Poli J (2021) A Role for the Mre11-Rad50-Xrs2 Complex in Gene Expression and Chromosome Organization.

Molecular Cell, 81, 183 - 197. doi:10.1016/j.molcel.2020.11.010

Cheblal A, Challa K, Seeber A, Shimada K, Yoshida H, Ferreira HC, Amitai A, Gasser SM (2021) DNA Damage-Induced Nucleosome Depletion Enhances Homology Search Independently of Local Break Movement.

Molecular Cell, 64, 951 - 966. doi: 10.1016/j.molcel.2016.10.032

Harr JC, Schmid CD, Munoz-Jiménez C, Romero-Bueno R, Kalck V, Gonzalez-Sandoval A, Hauer MH, Padeken J, Askjaer P, Mattout A, Gasser SM (2020) Loss of an H3K9me anchor rescues laminopathy-linked changes in nuclear organization and muscle function in an Emery-Dreifuss muscular dystrophy model.

Genes & Dev. 34, 560 - 579. doi:10.1101/gad.332213.119

Mattout A, Gaidatzis D, Padeken J, Schmid CD, Aeschimann F, Kalck V, Gasser SM (2020) LSM2-8 and XRN-2 contribute to the silencing of H3K27me3-marked genes through targeted RNA decay.

Nature Cell Biology, 22, 579 - 590. doi: 10.1038/s41556-020-0504-1.

Deshpande, I., Keusch, J., Challa, K., Iesmantavicius, V., Gasser, S.M. and Gut, H. (2019) A Sir4 H-BRCT domain interacts with phospho-proteins to sequester and repress yeast heterochromatin

EMBO J. 38(20), e101744. doi: 10.15252/embj.2019101744.

Delaney, CE, Methot, SP, Guidi, M, Katic, I, Gasser, SM, Padeken, J. (2019) Heterochromatic foci and transcriptional repression by an unstructured MET-2/SETDB1 co-factor LIN-65

J. Cell Biol. 218, 820 - 838. doi: 10.1083/jcb.201811038.

Padeken J, Zeller P, Towbin B, Katic I, Kalck V, Methot SP, Gasser SM. (2019) Synergistic lethality between BRCA1 and H3K9me2 loss reflects satellite derepression.

Genes & Dev. 33, 436 - 451. doi: 10.1101/gad.322495.118.

Cabianca, D.S., Munoz Jimenez, C., Kalck, V., Gaidatzis, D., Padeken, J., Seeber, A., Askjaer, P. and Gasser, S.M. (2019) Active chromatin marks drive spatial sequestration of heterochromatin in C. elegans nuclei

Nature, 569, 734 - 739. doi: 10.1038/s41586-019-1243-y.

PhD students

Anaïs Cheblal (2016-2020)
Verena Hurst (2016-2020)
Jan Marten Schmidt (2020)
Benoît Falquet (2018-2020)
Isabella Marcomini (2012-2018)
Michael Hauer (2013-2017)
Andrew Seeber (2011-2017)
Peter Zeller (2012-2017)
Adriana Gonzalez (2011-2016)
Nicole Hustedt (2010-2014)
Sabine Rohner (2009-2013)
Mariano Oppikofer (2008-2012)
Benjamin Towbin (2007-2012)
Anna Maria Hegnauer (2005-2010)
Lutz Gehlen (2004-2009)
Shigeki Nagai (2004-2009)
Fabrizio Martino (2004-2008)
Heiko Schober (2004-2008)
Thomas Schleker (2004-2007)
Ruchi Chauhan (2006-2007)
Frank Neumann (2005)

Postdoctoral fellows

Colin Delaney (2018-2021)
Kiran Challa (2017-2020)
Stephen Methot (2017-2020)
Jeannette Fuchs (2020)
Shany Koren (2020)
Daria Monogiou Belik (2020)
Daphne Cabianca (2013-2020)
Nicolas Mercado (2018-2020)
Micol Guidi (2017-2019)
Jennifer Harr (2015-2019)
Anna Mattout (2012-2019)
Neda Delgoshaie (2015-2018)
Christian Gerhold (2013-2017)
Jerome Poli (2014-2017)
Chihiro Horigome (2010-2015)
Helder Ferreira (2007-2013)
Vincent Dion (2008-2013)
Benjamin Towbin (2012-2013)
Stephanie Kueng (2007-2012)
Thibaud Jegou (2011)
Pierre Meister (2005-2011)
Niloofar Davoodi (2007-2011)
Lutz Gehlen (2009)
Brietta Pike (2006-2009)
Elisa Varela Sanz (2004-2008)
Kenji Shimada (2004-2007)
Haico Van Attikum (2004-2007)
Angela Taddei (2004-2006)
Olivier Fritsch (2004-2006)
Fabien Cubizolles (2005-2006)
Aaron Ponti (2005)

Technical/Research associates

Kenji Shimada (2007-2021)
Cleo Tarashev (2020-2021)
Veronique Kalck (2004-2020)
Christoph Schmid (2018-2020)
Peter David Cron (2018-2020)
Monika Tsai (2004-2017)
Monique Thomas-Seldran (2004-2005)
Thierry Laroche (2004)

Undergraduates

Saho Kitagawa (2020)
Mariya Kryzhanovska (2015-2016)
Christian Adrian Mueller (2015-2016)
Anya Wilson (2015)
Aline De Courten (2014)
Michael Hauer (2012-2013)
Fabrice Darbellay (2012)
Roger Schmid (2010-2011)
Alma Brostroem (2010)
Sabine Rohner (2008)
Benjamin Towbin (2006-2007)
Sabine Rohner (2006)

Visiting scientists

Azusa Uchimoto (2019)
Akito Funatsu (2019)
Haruka Yoshida (2019)
Ryoichi Inoue (2019)
Catia Attanasio (2016-2018)
Sukenao Koyabu (2018)
Saho Kitagawa (2017-2018)
Takumi Motokura (2017)
Io Yamamoto (2016)
Kiran Challa (2016)
Kei Kadoda (2015)
Miki Shinohara (2015)
Hisashi Kamido (2015)
Kyohei Kitamura (2015)
Mary Sopta (2014)
Kota Hashimoto (2014)
Kiwamu Doi (2014)
Sho Ishikawa (2014)
Masafumi Fukushima (2013)
Yo Murata (2013)
Jennifer Cobb (2013)
Shizuka Nohara (2013)
Kosuke Maeguchi (2012)
Mami Oi (2012)
Isabella Marcomini (2012)
Adriana Gonzalez (2011)
Mari Fujita (2011)
Yosef Gruenbaum (2010-2011)
Yuiko Hirata (2011)
Andrew Seeber (2011)
Raku Son (2010)
Munenori Kawai (2010)
Yuki Moriyama (2009)
Takaharu Sakuragi (2009)
Mohammad Sailani (2009)
Alix Christen (2009)
Anna Mattout (2008)
Yukako Oma (2007)
Eric Selker (2006-2007)
Jeanne Selker (2006-2007)
Takahito Yoshida (2005)

Education

1982
PhD (Biochemistry), University of Basel, Basel, Switzerland
1979
BA (Hons Biophysics), University of Chicago, Chicago, Ill., USA

Positions held

2021-
Director ISREC Foundation, Epalinges, Switzerland
2005-2020
Full Professor, Molecular Biology, University of Basel, Switzerland
2004-2020
Senior group leader, Friedrich Miescher Institute for Biomedical Research, Basel, Switzerland
2004-2019
Director, Friedrich Miescher Institute for Biomedical Research, Basel, Switzerland
2001-2004
Full Professor, Dept. of Molecular Biology, University of Geneva, Switzerland
1991-2001
Senior Group Leader, ISREC, Epalinges, Switzerland
1986-1991
Junior Group Leader, Swiss Institute for Experimental Cancer Research (ISREC), Epalinges, Switzerland
1983-1986
Postdoctoral Fellow, Dept. of Molecular Biology, University of Geneva, Geneva, Switzerland

Honors

2020-2023
Member, Biozentrum Scientific Advisory Board, University of Basel
2018-
Member of the Executive Board of Accentus and Empiris Foundations, Zürich
2018-
Member of the Governing Board of the ETH Domain, Bern and Zürich
2017-2020
Member, Swiss Tropical & Public Health Institute, Scientific Advisory Board
2017-2020
Member, Univ. Tokyo Institute of Quant. Sciences, Scientific Advisory Board
2017-2019
Who's who in Switzerland, Who's who in Germany
2016-2022
Member, Crick Institute Scientific Advisory Board, London
2016-2022
Member, Swiss Science Council (SSC, advising Science Ministry)
2016
Honorary Doctorate in Medicine, Charles University of Prague
2016
Lee Hartwell Award, Genetics Society of America
2015-2021
Member, EMBL Scientific Advisory Council, Heidelberg
2015-2021
Member, Gairdner Prize Advisory committee, Toronto, Canada
2014-2019
Chair, Swiss National Science Foundation Gender Commission
2014-2018
Chair, Career Development Grant Review Committee HFSPO, Strasbourg
2014-2018
Member, Executive Board, Genomics Institute of the Novartis Res. Foundation
2014-2018
Scientific Review Board of Netherlands Cancer Institute, Amsterdam, NL
2014
Honorary Doctorate in Molecular biology, University of Lausanne
2013-2018
Member, Wissenschaftlicher Beirat of the Instituteof Advanced Study, Berlin
2013-2015
Member of the EC President's Science and Technology Advisory Council
2013
Weizmann Institute, Women in Science Award
2012-2016
Advisory Board for Max Planck Institute for Biophysical Chemistry, Göttingen
2012
EMBO/FEBS Women in Science Award
2011
Prix International de l'INSERM, France
2009
Election to American Association for the Advancement of Science
2009
London Royal Society of Chemistry "Nucleic Acid" Award
2008-2018
Member of the Nestlé Nutrition Council, Nestlé SA8
2007
Election to German Academy of Science, Leopoldina
2006
Election to Academy of Medical Sciences, Switzerland
2006
Gregor Mendel Medal, Czech Academy of Science
2006
Otto Naegeli Prize for Biomedical Research, Switzerland
2005-2016
Board of Directors, Gebert Rüf Foundation, Basel
2005
Foreign member, Académie des Sciences, Institut de France
2000-2004
Vice Chair and then Chair, EMBO Council, Heidelberg
1998
Election to Academia Europaea
1994
Friedrich Miescher Prize, Swiss Society for Biochemistry
1993
Member, EMBO