Rainer W. Friedrich
Group News
Oct 5, 2021 Worm atlas could help crack mysteries in animal evolution |
Aug 2, 2021 From imaging neurons to measuring their true activity |
Mar 7, 2020 Forscher entwerfen eine virtuelle Welt für Zebrafische |
Mar 3, 2020 A glitch in the Matrix: Using virtual reality to understand how fish predict the future |
Jan 21, 2020 Reconstructing structure and function of a neuronal circuit |
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Rainer W. Friedrich
Neuronal circuits and computations
The goal of our research is to understand how neuronal circuits perform intelligent computations. Unlike most technical devices, brains learn to interpret their environment from experience and use this knowledge to inform behavior. These processes involve the recognition of behaviorally relevant regularities in the world and the generation of predictions for behavior. To explore the underlying fundamental computations we study information processing and memory in the olfactory system.
Our work takes advantage of zebrafish as a model system and combines analyses of single neurons, neuronal population activity, circuit connectivity, and behavior. We ask how high-dimensional sensory stimuli are represented and processed in the olfactory bulb and cortex, and how information processing is modified during learning. Higher brain functions depend on refinements of network connectivity that continuously modify information processing based on an individual's experience. We explore the underlying mechanisms by combining analyses of connectivity ("connectomics") with studies of circuit function and behavior. This work bridges the gap between experiment and theory.
Additional research focuses on circuit dysfunctions in genetic models of autism spectrum disorders and other diseases. The goal of this research is to obtain deeper insights into disease mechanisms at the level of neuronal circuit structure and function.
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Rainer W. Friedrich
This is a list of selected publications from this group. For a full list of publications, please visit our Publications page and search by group name.
Anneser, L., Satou, C., Hotz, H.R., and Friedrich, R.W. (2024) Molecular organization of neuronal cell types and neuromodulatory systems in the zebrafish telencephalon
Curr Biol 34, 298-312 e294. 10.1016/j.cub.2023.12.003Satou, C., Neve, R.L., Oyibo, H.K., Zmarz, P., Huang, K.H., Arn Bouldoires, E., Mori, T., Higashijima, S.I., Keller, G.B., and Friedrich, R.W. (2022) A viral toolbox for conditional and transneuronal gene expression in zebrafish
eLife 11. 10.7554/eLife.77153Friedrich RW, Wanner AA (2021) Dense Circuit Reconstruction to Understand Neuronal Computation: Focus on Zebrafish
Annu Rev Neurosci 44:275-293Rupprecht P, Carta S, Hoffmann A, Echizen M, Blot A, Kwan AC, Dan Y, Hofer SB, Kitamura K, Helmchen F, Friedrich RW (2021) A database and deep learning toolbox for noise-optimized, generalized spike inference from calcium imaging
Nat Neurosci 24:1324-1337Vergara HM, Pape C, Meechan KI, Zinchenko V, Genoud C, Wanner AA, Mutemi KN, Titze B, Templin RM, Bertucci PY, Simakov O, Durichen W, Machado P, Savage EL, Schermelleh L, Schwab Y, Friedrich RW, Kreshuk A, Tischer C, Arendt D (2021) Whole-body integration of gene expression and single-cell morphology
Cell 184:4819-4837 e4822Huang KH, Rupprecht P, Frank T, Kawakami K, Bouwmeester T, Friedrich RW (2020) A virtual reality system to analyze neural activity and behavior in adult zebrafish.
Nature Methods 17:343-351Wanner AA, Friedrich RW (2020) Whitening of odor representations by the wiring diagram of the olfactory bulb.
Nature Neurosci 23:433-442Frank T, Mönig NR, Satou C, Higashijima S-i, Friedrich RW (2019) Associative conditioning remaps odor representations and modifies inhibition in a higher olfactory brain area
Nature Neurosci 22:1844-1856Rupprecht, P., Friedrich, R.W. (2018) Precise synaptic balance in the zebrafish homolog of olfactory cortex
Neuron 100, 669-683Jacobson, G., Rupprecht, P., Friedrich, R.W. (2018) Experience-dependent plasticity of odor representations in the telencephalon of zebrafish
Curr Biol, 28, 1-14Wanner AA, Genoud C, Masudi T, Siksou L, Friedrich RW (2016) Dense EM-based reconstruction of the interglomerular projectome in the zebrafish olfactory bulb
Nat Neurosci. 2016 Apr; [Epub ahead of print]Zhu P, Frank T, Friedrich RW (2013) Equalization of odor representations by a network of electrically coupled inhibitory interneurons
Nature Neurosci. 16:1678-1686Friedrich RW (2013) Information processing in the olfactory system of zebrafish
Annu Rev Neurosci 36: 383-402Bundschuh ST, Zhu P, Zhang Schärer Y-P, Friedrich RW (2012) Dopaminergic modulation of mitral cells and odor responses in the zebrafish olfactory bulb
J Neurosci 32:6830-6840Zhu P, Fajardo O, Shum J, Zhang Schärer Y-P, Friedrich RW (2012) High-resolution optical control of spatiotemporal neuronal activity patterns in zebrafish using a digital micromirror device
Nat Protoc 7: 1410-25Blumhagen F, Zhu P, Shum J, Scharer YP, Yaksi E, Deisseroth K, Friedrich RW (2011) Neuronal filtering of multiplexed odour representations
Nature 479:493-498Niessing J, Friedrich RW (2010) Olfactory pattern classification by discrete neuronal network states
Nature 465:47-52Wiechert MT, Judkewitz B, Riecke H, Friedrich RW (2010) Mechanisms of pattern decorrelation by recurrent neuronal circuits
Nature Neurosci 13:1003-1010Yaksi E, von Saint Paul F, Niessing J, Bundschuh ST, Friedrich RW (2009) Transformation of odor representations in target areas of the olfactory bulb
Nature Neurosci 12:474-482Full list of publications
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