Rainer W. Friedrich

Group News

Mar 7, 2020
Forscher entwerfen eine virtuelle Welt für Zebrafische
Mar 3, 2020
A glitch in the Matrix: Using virtual reality to understand how fish predict the future
Jan 21, 2020
Reconstructing structure and function of a neuronal circuit
Oct 8, 2019
Complex odors made simple
Nov 19, 2018
Precise synaptic organization of a memory network
All group news

Resources

FMI report pages

Rainer W. Friedrich

Neuronal circuits and computations

The goal of our research is to understand how neuronal circuits perform intelligent computations. Unlike most technical devices, brains learn to interpret their environment from experience and use this knowledge to inform behavior. These processes involve the recognition of behaviorally relevant regularities in the world and the generation of predictions for behavior. To explore the underlying fundamental computations we study information processing and memory in the olfactory system.

Our work takes advantage of zebrafish as a model system and combines analyses of single neurons, neuronal population activity, circuit connectivity, and behavior. We ask how high-dimensional sensory stimuli are represented and processed in the olfactory bulb and cortex, and how information processing is modified during learning. Higher brain functions depend on refinements of network connectivity that continuously modify information processing based on an individual's experience. We explore the underlying mechanisms by combining analyses of connectivity ("connectomics") with studies of circuit function and behavior. This work bridges the gap between experiment and theory.

Additional research focuses on circuit dysfunctions in genetic models of autism spectrum disorders and other diseases. The goal of this research is to obtain deeper insights into disease mechanisms at the level of neuronal circuit structure and function.

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Rainer W. Friedrich

This is a list of selected publications from this group. For a full list of publications, please visit our Publications page and search by group name.


Huang KH, Rupprecht P, Frank T, Kawakami K, Bouwmeester T, Friedrich RW (2020) A virtual reality system to analyze neural activity and behavior in adult zebrafish.

Nature Methods 17:343-351

Wanner AA, Friedrich RW (2020) Whitening of odor representations by the wiring diagram of the olfactory bulb.

Nature Neurosci 23:433-442

Frank T, Mönig NR, Satou C, Higashijima S-i, Friedrich RW (2019) Associative conditioning remaps odor representations and modifies inhibition in a higher olfactory brain area

Nature Neurosci 22:1844-1856

Rupprecht, P., Friedrich, R.W. (2018) Precise synaptic balance in the zebrafish homolog of olfactory cortex

Neuron 100, 669-683

Jacobson, G., Rupprecht, P., Friedrich, R.W. (2018) Experience-dependent plasticity of odor representations in the telencephalon of zebrafish

Curr Biol, 28, 1-14

Wanner AA, Genoud C, Masudi T, Siksou L, Friedrich RW (2016) Dense EM-based reconstruction of the interglomerular projectome in the zebrafish olfactory bulb

Nat Neurosci. 2016 Apr; [Epub ahead of print]

Zhu P, Frank T, Friedrich RW (2013) Equalization of odor representations by a network of electrically coupled inhibitory interneurons

Nature Neurosci. 16:1678-1686

Friedrich RW (2013) Information processing in the olfactory system of zebrafish

Annu Rev Neurosci 36: 383-402

Bundschuh ST, Zhu P, Zhang Schärer Y-P, Friedrich RW (2012) Dopaminergic modulation of mitral cells and odor responses in the zebrafish olfactory bulb

J Neurosci 32:6830-6840

Zhu P, Fajardo O, Shum J, Zhang Schärer Y-P, Friedrich RW (2012) High-resolution optical control of spatiotemporal neuronal activity patterns in zebrafish using a digital micromirror device

Nat Protoc 7: 1410-25

Blumhagen F, Zhu P, Shum J, Scharer YP, Yaksi E, Deisseroth K, Friedrich RW (2011) Neuronal filtering of multiplexed odour representations

Nature 479:493-498

Niessing J, Friedrich RW (2010) Olfactory pattern classification by discrete neuronal network states

Nature 465:47-52

Wiechert MT, Judkewitz B, Riecke H, Friedrich RW (2010) Mechanisms of pattern decorrelation by recurrent neuronal circuits

Nature Neurosci 13:1003-1010

Yaksi E, von Saint Paul F, Niessing J, Bundschuh ST, Friedrich RW (2009) Transformation of odor representations in target areas of the olfactory bulb

Nature Neurosci 12:474-482

Full list of publications
» Search with Medline

Members

Group leader

Rainer W. Friedrich (Senior group leader)

PhD students

Tommaso Caudullo (PhD student)
Bo Hu (PhD student)
Nila Moenig (PhD student)
Ruth Montano (PhD student)
Nesibe Z. Temiz (PhD student)

Postdoctoral fellows

Claire Meissner-Bernard (Postdoctoral fellow)
Kim Palacios Flores (Postdoctoral fellow)
Chie Satou (Postdoctoral fellow)

Technical/Research associates

Estelle Arn (Lab manager)
Jan Eckhardt (Research associate )
Benjamin Titze (Imaging analysis programmer)

Visiting scientists

Oded Mayseless (Visiting scientist)

Alumni

PhD students

Peter Rupprecht (2014-2018)
Adrian Wanner (2009-2016)
Tafheem Masudi (2011-2016)
Ming Zou (2009-2014)
Sebastian Bundschuh (2007-2011)
Martin Wiechert (2007-2011)
Joern Niessing (2007-2009)
Francisca von Saint Paul (2007-2009)

Postdoctoral fellows

Kuo-Hua Huang (2013-2020)
Thomas Frank (2011-2019)
Peter Rupprecht (2018-2019)
Stephan Gerhard (2016-2019)
Benjamin Titze (2014-2018)
Anastasios Moressis (2012-2018)
Adrian Wanner (2016-2017)
Iori Namekawa (2009-2016)
Gilad Jacobson (2009-2015)
Jiang Hao (2012-2013)
Lea Siksou (2011-2013)
Peixin Zhu (2007-2013)
Otto Fajardo (2009-2013)
Yan-Ping Zhang Schaerer (2008-2012)
Martin Wiechert (2011)
Joern Niessing (2010)
Bidisha Chattopadhyaya (2007)
Jun Li (2007)

Technical/Research associates

Marcus Leinweber (2019-2020)
Martin Naegeli (2007-2019)

Undergraduates

Laura Kruempelmann (2017)
Aeneas Florian Bernardi (2016)
Aeneas Florian Bernardi (2016)
Peter Rupprecht (2013)
Cedric Van den Berg (2010-2012)
Denise Kranz (2009)
Jennifer Shum (2008-2009)
Sonja Degner (2008-2009)

Visiting scientists

Stefano Fusi (2016)
Fred Wolf (2016)
Paul de Koninck (2011-2012)

Education

1998
PhD, University of Tübingen and Max Planck Institute for Developmental Biology, Tübingen, Germany
1995
MSc, University of Freiburg, Freiburg, Germany

Positions held

2007-
Senior Group Leader, Friedrich Miescher Institute for Biomedical Research, Basel
2001-2007
Research Group Leader, Max Planck Institute for Medical Research, Heidelberg, Germany
2000-2001
Junior Group Leader, Max Planck Institute for Medical Research, Heidelberg, Germany
1998-2000
Postdoctoral Fellow, California Institute of Technology, Pasadena, USA
1998
Postdoctoral Fellow, Max Planck Institute for Developmental Biology, Tübingen, Germany

Honors

2014
Academia Europaea Member
2014
EMBO member
2012
Delwart Prize, Delwart Foundation
2011
Adjunct Professor, University of Basel
2003
James Heinemann Research Award, Minna James Heinemann Foundation
1999-2000
Otto Hahn Fellowship, Max Planck Society
1998-1999
Research Fellowship, Del Webb Foundation
1998
Attempto Award for Research Achievements, University of Tübingen
1997
Otto Hahn Medal of the Max Planck Society
1995-1998
Fellowship, Boehringer Ingelheim Fonds
1993
Member, Studienstiftung des deutschen Volkes