Filippo M. Rijli
Group News
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Feb 18, 2021 New-found molecular signature keeps key genes ready for action |
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Jun 22, 2020 Building corticocerebellar neural circuits |
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Oct 23, 2018 ERC Synergy Grant - epigenetics of cartilage repair and regeneration |
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Oct 5, 2018 Congratulations to the FMI Prize winners 2018 |
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Jul 18, 2018 New EMBO and HFSP fellows at FMI |
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Filippo M. Rijli
Transcriptional and epigenetic regulation of craniofacial and neuronal development
Our recent work focuses on the transcriptional and epigenetic mechanisms underlying craniofacial development and the sensory mapping of facial structures in the brain. To this end, we established in vivo genome-wide approaches to identify chromatin signatures underlying the molecular identities of selected subpopulations of cranial neural crest cells and neurons of the somatosensory circuits in the mouse hindbrain (brainstem). Moreover, to explore the transcriptional mechanisms of assembly of sensory connectivity maps, we study the functional role of the Hox gene family encoding homeodomain transcription factors. We also address the role of selected epigenetic regulators, including members of Polycomb repressive complexes.
The ad hoc genetic tools we use in mice include imaging of fluorescently labeled neurons and axonal tracts, trans-synaptic viral tracing of defined subpopulations, in utero electroporation, and in vivo genome-wide analysis of gene expression and chromatin organization of cell subpopulations.
Our studies may enhance understanding of the basic molecular mechanisms that establish precise connectivity between neurons and contribute to the definition of the etiology of certain developmental craniofacial syndromes.
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Filippo M. Rijli
This is a list of selected publications from this group. For a full list of publications, please visit our Publications page and search by group name.
Taro Kitazawa, Dania Machlab, Onkar Joshi, Nicola Maiorano, Hubertus Kohler, Sebastien Ducret, Sandra Kessler, Henrik Gezelius, Charlotte Soneson, Panagiotis Papasaikas, Guillermina Lopez-Bendito, Michael B. Stadler and Filippo M. Rijli (2021) A unique bipartite Polycomb signature regulates stimulus-response transcription during development
Nature Genetics (advance online publication)Maheshwari U, Kraus D, Vilain N, Holwerda SJB, Cankovic V, Maiorano NA, Kohler H, Satoh D, Sigrist M, Arber S, Kratochwil CF, Di Meglio T, Ducret S, Rijli FM (2020) Postmitotic Hoxa5 Expression Specifies Pontine Neuron Positional Identity and Input Connectivity of Cortical Afferent Subsets.
Cell Rep. 2020 Jun 16;31(11):107767Riva M, Genescu I, Habermacher C, Orduz D, Ledonne F, Rijli FM, Lopez-Bendito G, Coppola E, Garel S, Angulo MC, Pierani A. (2019) Activity-dependent death of transient Cajal-Retzius neurons is required for functional cortical wiring.
Elife. 2019 Dec 31;8:e50503Coughlan E, Garside VC, Wong SFL, Liang H, Kraus D, Karmakar K, Maheshwari U, Rijli FM, Bourne J, McGlinn E. (2019) A Hox Code Defines Spinocerebellar Neuron Subtype Regionalization.
Cell Rep. 2019 Nov 19;29(8):2408-2421.e4Kitazawa T, Rijli FM (2018) Barrelette map formation in the prenatal mouse brainstem
Curr Opin Neurobiol 53:210-219Kitazawa T, Rijli FM (2018) Integrating into the Rhombomere Community across the Border
Dev Cell 45(5):546-548Kitazawa T, Rijli FM (2017) Nuclear pore protein meets transcription factor in neural fate
Neuron 96:259-261Minoux M, Holwerda S, Vitobello A, Kitazawa T, Kohler H, Stadler M, Rijli FM (2017) Gene bivalency at polycomb domains regulates cranial neural crest positional identity
Science, 355:eaal2913Karmakar K, Narita Y, Fadok J, Loche A, Fadok J, Genoud C, Ducret S, Di Meglio T, Thierry R, Bacelo J, Lüthi A, Rijli FM (2017) Hoxa2 and Hoxb2 are required for tonotopic map precision and sound discrimination in the mouse auditory brainstem
Cell Reports, 18:185-197Moreno-Juan V, Filipchuk A, Antón-Bolaños N, Mezzera C, Gezelius H, Andrés B, Rodriguez Malmierca L, Susín R, Schaad O, Rutlin M, Nelson S, Ducret S, Valdeolmillos M, Rijli FM, López-Bendito G (2017) Prenatal thalamic waves regulate cortical area size prior to sensory processing
Nature Comm, 8:14172Bechara A, Laumonnerie C, Vilain N, Kratochwil CF, Cankovic V, Maiorano NA, Kirschmann MA, Ducret S, Rijli FM (2015) Hoxa2 selects barrelette neuron identity and connectivity in the mouse somatosensory brainstem
Cell Reports. 2015 Oct. [Epub ahead of print]Laumonnerie C*, Bechara A*, Vilain N, Kurihara Y, Kurihara H, Rijli FM (2015) Facial whisker pattern is not sufficient to instruct a whisker-related topographic map in the mouse somatosensory brainstem.
Development. 2015 Sep. [Epub ahead of print]* co-first authors
Minoux M, Kratochwil CF, Ducret S, Amin S, Kitazawa T, Kurihara H, Bobola N, Vilain N, Rijli FM (2013) Mouse Hoxa2 mutations provide a model for microtia and auricle duplication
Development 140:4386-97Di Bonito M, Narita Y, Avallone B, Sequino L, Mancuso M, Andolfi G, Franzè AM, Puelles L, Rijli FM*, Studer M* (2013) Assembly of the auditory circuitry by a hox genetic network in the mouse brainstem
PLoS Genet 9:e1003249* corresponding authors
Di Meglio T, Kratochwil CF, Vilain N, Loche A, Vitobello A, Yonehara K, Hrycaj SM, Roska B, Peters AHFM, Eichmann A, Wellik D, Ducret S, Rijli FM (2013) Ezh2 orchestrates topographic tangential migration and connectivity of mouse precerebellar neurons
Science, 339:204-207Vitobello A, Ferretti E, Lampe X, Vilain N, Ducret S, Ori M, Spetz JF, Selleri L, Rijli FM (2011) Hox and Pbx factors control retinoic acid synthesis during hindbrain segmentation
Dev Cell. 20:469-82Erzurumlu RS, Murakami Y, Rijli FM (2010) Mapping the face in the somatosensory brainstem
Nat Rev Neurosci 11:252-63Minoux M, Rijli FM (2010) Molecular mechanisms of cranial neural crest cell migration and patterning in craniofacial development
Development 137(16):2605-21Minoux M, Antonarakis GS, Kmita M, Duboule D, Rijli FM (2009) Rostral and caudal pharyngeal arches share a common neural crest ground pattern
Development 136:637-645Geisen MJ, Di Meglio T, Pasqualetti M, Ducret S, Brunet JF, Chedotal A, Rijli FM (2008) Hox paralogue group 2 genes control the migration of mouse pontine neurons through slit-robo signaling
PLoS Biol;6(6):e142Oury F, Murakami Y, Renaud JS, Pasqualetti M, Charnay P, Ren SY, Rijli FM (2006) Hoxa2- and rhombomere-dependent development of the mouse facial somatosensory map
Science 313:1408-1413Full list of publications
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