Georg Keller

Group News

Oct 18, 2023
Expectation vs. Reality: study maps the neurons that tell the difference
Jul 18, 2023
Mouse study sheds light on how antipsychotics work
Jan 14, 2023
Lassen sich Tiere mit Virtual-Reality-Brillen austricksen?
Dec 7, 2021
How sound changes sight
Nov 5, 2021
Congratulations to the winners of the FMI Science Prizes 2021
All group news


Georg Keller

Cortical computations

Our aim is to understand the computational algorithm of neocortex. Our research is based on the central hypothesis that cortical function is governed by internal models of the environment. Sensory input is compared to predictions of sensory input based on these internal models to compute prediction errors. This would mean that much of what we perceive is not the result of what our sensory organs transmit to our brains but either the result of what we expect to perceive or the result of a large deviation from these expectations.

To investigate cortical processing, we use a combination of imaging and electrophysiological techniques to record activity of individual cortical neurons during a behavioral task performed in a virtual reality environment. We use molecular techniques to target our recordings to specific cell populations in order to identify the different functional elements of the circuit. Based on these experiments and theoretical considerations we then attempt to infer the basic functional principles underlying cortical processing.

Georg Keller

This is a list of selected publications from this group. For a full list of publications, please visit our Publications page and search by group name.

Felix C Widmer, Sean M O'Toole, Georg B Keller (2022) NMDA receptors in visual cortex are necessary for normal visuomotor integration and skill learning

eLife 11:e71476

Aleena R. Garner and Georg B. Keller (2022) A cortical circuit for audio-visual predictions.

Nature Neuroscience 25: 98-105

Rebecca Jordan, Georg B. Keller (2020) Opposing influence of top-down and bottom-up input on excitatory layer 2/3 neurons in mouse primary visual cortex.

Neuron 108(6):1194-1206.e5.

Georg B. Keller, Thomas D. Mrsic-Flogel (2018) Predictive Processing: A Canonical Cortical Computation

Neuron 100: issue 2, P424-435

Heindorf M, Arber S, Keller GB (2018) Mouse Motor Cortex Coordinates the Behavioral Response to Unpredicted Sensory Feedback

Neuron 99:1040-1050.e5

Leinweber M, Ward DR, Sobczak JM, Attinger A, Keller GB (2017) A sensorimotor circuit in mouse cortex for visual flow predictions

Neuron 95:1420-1432.e5

Attinger A*, Wang B*, Keller GB (2017) Visuomotor coupling shapes the functional development of mouse visual cortex

Cell 169:1291-1302.e14
*equal contribution

Keller AJ, Houlton R, Kampa BM, Lesica NA, Mrsic-Flogel TD, Keller GB*, Helmchen F* (2017) Stimulus relevance modulates contrast adaptation in visual cortex

Elife 6. doi:10.7554/eLife.21589
* equal contributions

Zmarz P, Keller GB (2016) Mismatch receptive fields in mouse visual cortex

Neuron 92:766-772

Fiser A*, Mahringer D*, Oyibo HK*, Petersen AV, Leinweber M, Keller GB (2016) Experience-dependent spatial expectations in mouse visual cortex

Nat Neurosci. 19:1658-1664
* equal contributions

Liebscher S, Keller GB, Goltstein PM, Bonhoeffer T, Hübener M (2016) Selective persistence of sensorimotor mismatch signals in visual cortex of behaving Alzheimer's disease mice

Curr Biol 26:956-964

Leinweber M*, Zmarz P*, Argast P, Buchmann P, Hübener M, Bonhoeffer T, Keller GB (2014) Two-photon calcium imaging in mice navigating a virtual reality environment

J Vis Exp 84:e50885, doi:10.3791/50885
* equal contributions

Keller GB, Bonhoeffer T, Hübener M (2012) Sensorimotor mismatch signals in primary visual cortex of the behaving mouse

Neuron 74:809-815

Keller GB, Hahnloser RHR (2009) Neural processing of auditory feedback during vocal practice in a songbird

Nature 457:187-90

Full list of publications
» Search with Medline


Group leader

In current position since 2012
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PhD students

In current position since 2024
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In current position since 2020
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In current position since 2022
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In current position since 2022
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In current position since 2023
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In current position since 2021
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Postdoctoral fellows

In current position since 2023
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In current position since 2021
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In current position since 2024
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Technical/Research associates

In current position since 2023
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In current position since 2018
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Visiting scientists

In current position since 2021
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PhD students

Baba Yogesh (2017-2023)
Felix Widmer (2016-2021)
Marina Moric (2017-2020)
David Mahringer (2013-2019)
Alexander Attinger (2013-2018)
Matthias Heindorf (2017)
Pawel Zmarz (2012-2017)
Bo Wang (2012-2017)
Aris Fiser (2013-2017)

Postdoctoral fellows

Sean O'Toole (2017-2023)
Matthias Heindorf (2017-2023)
Rebecca Jordan (2018-2023)
Aleena Garner (2016-2022)
Hassana Oyibo (2014-2022)
Koshika Yadava (2020-2021)
Marcus Leinweber (2012-2019)
Aris Fiser (2018-2019)
Daniel Ward (2014-2015)

Technical/Research associates

Daniela Gerosa Erni (2012-2020)


Ahmed Aizi (2023)
Alice Schildkamp (2023)
Mar Boleda Pellicer (2023)
Leonora Pinter (2023)
Ahmed Aizi (2022)
Beatriz Lucia Saenz de Buruaga Corrochano (2022)
Cedric Moser (2020-2022)
Jan Sobczak (2014-2016)
Felix Widmer (2015)
Alexander Attinger (2013)
Ulisses Marti-Mengual (2013)

Visiting scientists

Mahesh Karnani (2020-2023)
Andreas Keller (2020-2023)
Anders Petersen (2015-2016)
Kareny Dominguez (2013)


PhD, Institute of Neuroinformatics, University of Zurich, ETH Zürich
MSc, Swiss Federal Institute of Technology (ETH), Zürich

Positions held

Senior Group Leader, Friedrich Miescher Institute for Biomedical Research, Basel, Switzerland
Junior Group Leader, Friedrich Miescher Institute for Biomedical Research, Basel, Switzerland
Postdoctoral Fellow, Max Planck Institute of Neurobiology


Human Frontier Science Program Career Development Award
Max Planck Institute of Neurobiology Young Scientist Award
Human Frontier Science Program Long-term Fellowship
Swiss National Science Foundation Fellowship for Prospective Researchers