Georg Keller

Group News

Oct 21, 2020
How the visual cortex combines movement and vision
Feb 12, 2019
Alexander Attinger and Bo Wang awarded Pfizer Research Prize 2019
Aug 23, 2018
Motor cortex needed for sensory-guided control of movement
Sep 14, 2017
Predicting what we'll see
Jun 22, 2017
Coupling of movement and vision
All group news


FMI report pages

Georg Keller

Cortical computations

Our aim is to understand the computational algorithm of neocortex. Our research is based on the central hypothesis that cortical function is governed by internal models of the environment. Sensory input is compared to predictions of sensory input based on these internal models to compute prediction errors. This would mean that much of what we perceive is not the result of what our sensory organs transmit to our brains but either the result of what we expect to perceive or the result of a large deviation from these expectations.

To investigate cortical processing, we use a combination of imaging and electrophysiological techniques to record activity of individual cortical neurons during a behavioral task performed in a virtual reality environment. We use molecular techniques to target our recordings to specific cell populations in order to identify the different functional elements of the circuit. Based on these experiments and theoretical considerations we then attempt to infer the basic functional principles underlying cortical processing.

Georg Keller

This is a list of selected publications from this group. For a full list of publications, please visit our Publications page and search by group name.

Rebecca Jordan, Georg B. Keller (2020) Opposing influence of top-down and bottom-up input on excitatory layer 2/3 neurons in mouse primary visual cortex.

Neuron (advance online publication)

Georg B. Keller, Thomas D. Mrsic-Flogel (2018) Predictive Processing: A Canonical Cortical Computation

Neuron 100: issue 2, P424-435

Heindorf M, Arber S, Keller GB (2018) Mouse Motor Cortex Coordinates the Behavioral Response to Unpredicted Sensory Feedback

Neuron 99:1040-1050.e5

Leinweber M, Ward DR, Sobczak JM, Attinger A, Keller GB (2017) A sensorimotor circuit in mouse cortex for visual flow predictions

Neuron 95:1420-1432.e5

Attinger A*, Wang B*, Keller GB (2017) Visuomotor coupling shapes the functional development of mouse visual cortex

Cell 169:1291-1302.e14
*equal contribution

Keller AJ, Houlton R, Kampa BM, Lesica NA, Mrsic-Flogel TD, Keller GB*, Helmchen F* (2017) Stimulus relevance modulates contrast adaptation in visual cortex

Elife 6. doi:10.7554/eLife.21589
* equal contributions

Zmarz P, Keller GB (2016) Mismatch receptive fields in mouse visual cortex

Neuron 92:766-772

Fiser A*, Mahringer D*, Oyibo HK*, Petersen AV, Leinweber M, Keller GB (2016) Experience-dependent spatial expectations in mouse visual cortex

Nat Neurosci. 19:1658-1664
* equal contributions

Liebscher S, Keller GB, Goltstein PM, Bonhoeffer T, Hübener M (2016) Selective persistence of sensorimotor mismatch signals in visual cortex of behaving Alzheimer's disease mice

Curr Biol 26:956-964

Leinweber M*, Zmarz P*, Argast P, Buchmann P, Hübener M, Bonhoeffer T, Keller GB (2014) Two-photon calcium imaging in mice navigating a virtual reality environment

J Vis Exp 84:e50885, doi:10.3791/50885
* equal contributions

Keller GB, Bonhoeffer T, Hübener M (2012) Sensorimotor mismatch signals in primary visual cortex of the behaving mouse

Neuron 74:809-815

Keller GB, Hahnloser RHR (2009) Neural processing of auditory feedback during vocal practice in a songbird

Nature 457:187-90

Full list of publications
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Group leader

Joined group in 2012
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PhD students

Joined group in 2020
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Joined group in 2021
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Joined group in 2017
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Postdoctoral fellows

Joined group in 2016
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Joined group in 2017
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Joined group in 2018
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Joined group in 2017
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Joined group in 2014
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Technical/Research associates

Joined group in 2018
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Joined group in 2020
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Visiting scientists

Joined group in 2020
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Joined group in 2020
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PhD students

Felix Widmer (2016-2021)
Marina Moric (2017-2020)
David Mahringer (2013-2019)
Alexander Attinger (2013-2018)
Matthias Heindorf (2017)
Pawel Zmarz (2012-2017)
Bo Wang (2012-2017)
Aris Fiser (2013-2017)

Postdoctoral fellows

Koshika Yadava (2020-2021)
Marcus Leinweber (2012-2019)
Aris Fiser (2018-2019)
Daniel Ward (2014-2015)

Technical/Research associates

Daniela Gerosa Erni (2012-2020)


Jan Sobczak (2014-2016)
Felix Widmer (2015)
Alexander Attinger (2013)
Ulisses Marti-Mengual (2013)

Visiting scientists

Anders Petersen (2015-2016)
Kareny Dominguez (2013)


PhD, Institute of Neuroinformatics, University of Zurich, ETH Zürich
MSc, Swiss Federal Institute of Technology (ETH), Zürich

Positions held

Senior Group Leader, Friedrich Miescher Institute for Biomedical Research, Basel, Switzerland
Junior Group Leader, Friedrich Miescher Institute for Biomedical Research, Basel, Switzerland
Postdoctoral Fellow, Max Planck Institute of Neurobiology


Human Frontier Science Program Career Development Award
Max Planck Institute of Neurobiology Young Scientist Award
Human Frontier Science Program Long-term Fellowship
Swiss National Science Foundation Fellowship for Prospective Researchers