Georg Keller
Group News
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May 7, 2025 How the brain detects surprises — and why it could matter for mental health |
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Oct 18, 2023 Expectation vs. Reality: study maps the neurons that tell the difference |
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Jul 18, 2023 Mouse study sheds light on how antipsychotics work |
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Jan 14, 2023 Lassen sich Tiere mit Virtual-Reality-Brillen austricksen? |
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Dec 7, 2021 How sound changes sight |
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Resources
Georg Keller
Mechanisms of psychiatric treatments
We aim to understand the mechanisms that give rise to conscious perception and how these mechanisms are disrupted in psychiatric disorders. Our laboratory is dedicated to exploring the neuronal circuit basis of conscious perception and investigating how these circuits become dysregulated in disease. Specifically, we focus on the effects of consciousness-altering drugs, widely used in psychiatric treatments, on the mouse cortex.
Despite the extensive use of antipsychotic and antidepressant medications, surprisingly little is understood about their effect on neuronal activity. By identifying functional patterns in cortical activity that are common across drugs within the same category — independent of their receptor binding profiles — we aim to isolate the treatment-relevant changes induced by these drugs. This approach may reveal the core neural changes necessary for therapeutic efficacy. Ultimately, we aspire to leverage this understanding to develop alternative strategies for achieving similar therapeutic outcomes, potentially paving the way for more effective and targeted treatments.
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Georg Keller
This is a list of selected publications from this group. For a full list of publications, please visit our Publications page and search by group name.
Georg B. Keller and Philipp Sterzer (2024) Predictive Processing: A Circuit Approach to Psychosis
Annual Review of Neuroscience Volume 47Baba Yogesh, Georg B Keller (2024) Cholinergic input to mouse visual cortex signals a movement state and acutely enhances layer 5 responsiveness
eLife.89986.5Matthias Heindorf, Georg B Keller (2024) Antipsychotic drugs selectively decorrelate long-range interactions in deep cortical layers
eLife 12:RP86805Rebecca Jordan, Georg B Keller (2023) The locus coeruleus broadcasts prediction errors across the cortex to promote sensorimotor plasticity
eLife.85111.3Sean M. O'Toole, Hassana K. Oyibo, Georg B. Keller (2023) Molecularly targetable cell types in mouse visual cortex have distinguishable prediction error responses
Neuron, Volume 111, Issue 18, 2918 - 2928.e8Felix C Widmer, Sean M O'Toole, Georg B Keller (2022) NMDA receptors in visual cortex are necessary for normal visuomotor integration and skill learning
eLife 11:e71476Aleena R. Garner and Georg B. Keller (2022) A cortical circuit for audio-visual predictions.
Nature Neuroscience 25: 98-105Rebecca Jordan, Georg B. Keller (2020) Opposing influence of top-down and bottom-up input on excitatory layer 2/3 neurons in mouse primary visual cortex.
Neuron 108(6):1194-1206.e5.Georg B. Keller, Thomas D. Mrsic-Flogel (2018) Predictive Processing: A Canonical Cortical Computation
Neuron 100: issue 2, P424-435Heindorf M, Arber S, Keller GB (2018) Mouse Motor Cortex Coordinates the Behavioral Response to Unpredicted Sensory Feedback
Neuron 99:1040-1050.e5Leinweber M, Ward DR, Sobczak JM, Attinger A, Keller GB (2017) A sensorimotor circuit in mouse cortex for visual flow predictions
Neuron 95:1420-1432.e5Attinger A*, Wang B*, Keller GB (2017) Visuomotor coupling shapes the functional development of mouse visual cortex
Cell 169:1291-1302.e14*equal contribution
Keller AJ, Houlton R, Kampa BM, Lesica NA, Mrsic-Flogel TD, Keller GB*, Helmchen F* (2017) Stimulus relevance modulates contrast adaptation in visual cortex
Elife 6. doi:10.7554/eLife.21589* equal contributions
Zmarz P, Keller GB (2016) Mismatch receptive fields in mouse visual cortex
Neuron 92:766-772Fiser A*, Mahringer D*, Oyibo HK*, Petersen AV, Leinweber M, Keller GB (2016) Experience-dependent spatial expectations in mouse visual cortex
Nat Neurosci. 19:1658-1664* equal contributions
Liebscher S, Keller GB, Goltstein PM, Bonhoeffer T, Hübener M (2016) Selective persistence of sensorimotor mismatch signals in visual cortex of behaving Alzheimer's disease mice
Curr Biol 26:956-964Leinweber M*, Zmarz P*, Argast P, Buchmann P, Hübener M, Bonhoeffer T, Keller GB (2014) Two-photon calcium imaging in mice navigating a virtual reality environment
J Vis Exp 84:e50885, doi:10.3791/50885* equal contributions
Keller GB, Bonhoeffer T, Hübener M (2012) Sensorimotor mismatch signals in primary visual cortex of the behaving mouse
Neuron 74:809-815Keller GB, Hahnloser RHR (2009) Neural processing of auditory feedback during vocal practice in a songbird
Nature 457:187-90Full list of publications
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