Georg Keller
Group News
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Dec 7, 2021 How sound changes sight |
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Nov 5, 2021 Congratulations to the winners of the FMI Science Prizes 2021 |
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Oct 21, 2020 How the visual cortex combines movement and vision |
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Feb 12, 2019 Alexander Attinger and Bo Wang awarded Pfizer Research Prize 2019 |
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Aug 23, 2018 Motor cortex needed for sensory-guided control of movement |
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Georg Keller
Cortical computations
Our aim is to understand the computational algorithm of neocortex. Our research is based on the central hypothesis that cortical function is governed by internal models of the environment. Sensory input is compared to predictions of sensory input based on these internal models to compute prediction errors. This would mean that much of what we perceive is not the result of what our sensory organs transmit to our brains but either the result of what we expect to perceive or the result of a large deviation from these expectations.
To investigate cortical processing, we use a combination of imaging and electrophysiological techniques to record activity of individual cortical neurons during a behavioral task performed in a virtual reality environment. We use molecular techniques to target our recordings to specific cell populations in order to identify the different functional elements of the circuit. Based on these experiments and theoretical considerations we then attempt to infer the basic functional principles underlying cortical processing.
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Georg Keller
This is a list of selected publications from this group. For a full list of publications, please visit our Publications page and search by group name.
Felix C Widmer, Sean M O'Toole, Georg B Keller (2022) NMDA receptors in visual cortex are necessary for normal visuomotor integration and skill learning
eLife 11:e71476Aleena R. Garner and Georg B. Keller (2022) A cortical circuit for audio-visual predictions.
Nature Neuroscience 25: 98-105Rebecca Jordan, Georg B. Keller (2020) Opposing influence of top-down and bottom-up input on excitatory layer 2/3 neurons in mouse primary visual cortex.
Neuron 108(6):1194-1206.e5.Georg B. Keller, Thomas D. Mrsic-Flogel (2018) Predictive Processing: A Canonical Cortical Computation
Neuron 100: issue 2, P424-435Heindorf M, Arber S, Keller GB (2018) Mouse Motor Cortex Coordinates the Behavioral Response to Unpredicted Sensory Feedback
Neuron 99:1040-1050.e5Leinweber M, Ward DR, Sobczak JM, Attinger A, Keller GB (2017) A sensorimotor circuit in mouse cortex for visual flow predictions
Neuron 95:1420-1432.e5Attinger A*, Wang B*, Keller GB (2017) Visuomotor coupling shapes the functional development of mouse visual cortex
Cell 169:1291-1302.e14*equal contribution
Keller AJ, Houlton R, Kampa BM, Lesica NA, Mrsic-Flogel TD, Keller GB*, Helmchen F* (2017) Stimulus relevance modulates contrast adaptation in visual cortex
Elife 6. doi:10.7554/eLife.21589* equal contributions
Zmarz P, Keller GB (2016) Mismatch receptive fields in mouse visual cortex
Neuron 92:766-772Fiser A*, Mahringer D*, Oyibo HK*, Petersen AV, Leinweber M, Keller GB (2016) Experience-dependent spatial expectations in mouse visual cortex
Nat Neurosci. 19:1658-1664* equal contributions
Liebscher S, Keller GB, Goltstein PM, Bonhoeffer T, Hübener M (2016) Selective persistence of sensorimotor mismatch signals in visual cortex of behaving Alzheimer's disease mice
Curr Biol 26:956-964Leinweber M*, Zmarz P*, Argast P, Buchmann P, Hübener M, Bonhoeffer T, Keller GB (2014) Two-photon calcium imaging in mice navigating a virtual reality environment
J Vis Exp 84:e50885, doi:10.3791/50885* equal contributions
Keller GB, Bonhoeffer T, Hübener M (2012) Sensorimotor mismatch signals in primary visual cortex of the behaving mouse
Neuron 74:809-815Keller GB, Hahnloser RHR (2009) Neural processing of auditory feedback during vocal practice in a songbird
Nature 457:187-90Full list of publications
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