Group News

Oct 21, 2020
How the visual cortex combines movement and vision

Feb 12, 2019
Alexander Attinger and Bo Wang awarded Pfizer Research Prize 2019

Aug 23, 2018
Motor cortex needed for sensory-guided control of movement

Sep 14, 2017
Predicting what we'll see

Jun 22, 2017
Coupling of movement and vision

All group news

Resources

FMI report pages

Georg Keller

Cortical computations

Our aim is to understand the computational algorithm of neocortex. Our research is based on the central hypothesis that cortical function is governed by internal models of the environment. Sensory input is compared to predictions of sensory input based on these internal models to compute prediction errors. This would mean that much of what we perceive is not the result of what our sensory organs transmit to our brains but either the result of what we expect to perceive or the result of a large deviation from these expectations.

To investigate cortical processing, we use a combination of imaging and electrophysiological techniques to record activity of individual cortical neurons during a behavioral task performed in a virtual reality environment. We use molecular techniques to target our recordings to specific cell populations in order to identify the different functional elements of the circuit. Based on these experiments and theoretical considerations we then attempt to infer the basic functional principles underlying cortical processing.

Contact
Georg Keller

This is a list of selected publications from this group. For a full list of publications, please visit our Publications page and search by group name.

Rebecca Jordan, Georg B. Keller (2020) Opposing influence of top-down and bottom-up input on excitatory layer 2/3 neurons in mouse primary visual cortex.

Neuron (advance online publication)

Georg B. Keller, Thomas D. Mrsic-Flogel (2018) Predictive Processing: A Canonical Cortical Computation

Neuron 100: issue 2, P424-435

Heindorf M, Arber S, Keller GB (2018) Mouse Motor Cortex Coordinates the Behavioral Response to Unpredicted Sensory Feedback

Neuron 99:1040-1050.e5

Leinweber M, Ward DR, Sobczak JM, Attinger A, Keller GB (2017) A sensorimotor circuit in mouse cortex for visual flow predictions

Neuron 95:1420-1432.e5

Attinger A*, Wang B*, Keller GB (2017) Visuomotor coupling shapes the functional development of mouse visual cortex

Cell 169:1291-1302.e14
*equal contribution

Keller AJ, Houlton R, Kampa BM, Lesica NA, Mrsic-Flogel TD, Keller GB*, Helmchen F* (2017) Stimulus relevance modulates contrast adaptation in visual cortex

Elife 6. doi:10.7554/eLife.21589
* equal contributions

Zmarz P, Keller GB (2016) Mismatch receptive fields in mouse visual cortex

Neuron 92:766-772

Fiser A*, Mahringer D*, Oyibo HK*, Petersen AV, Leinweber M, Keller GB (2016) Experience-dependent spatial expectations in mouse visual cortex

Nat Neurosci. 19:1658-1664
* equal contributions

Liebscher S, Keller GB, Goltstein PM, Bonhoeffer T, Hübener M (2016) Selective persistence of sensorimotor mismatch signals in visual cortex of behaving Alzheimer's disease mice

Curr Biol 26:956-964

Leinweber M*, Zmarz P*, Argast P, Buchmann P, Hübener M, Bonhoeffer T, Keller GB (2014) Two-photon calcium imaging in mice navigating a virtual reality environment

J Vis Exp 84:e50885, doi:10.3791/50885
* equal contributions

Keller GB, Bonhoeffer T, Hübener M (2012) Sensorimotor mismatch signals in primary visual cortex of the behaving mouse

Neuron 74:809-815

Keller GB, Hahnloser RHR (2009) Neural processing of auditory feedback during vocal practice in a songbird

Nature 457:187-90

Full list of publications
» Search with Medline