Georg Keller

Group News

Oct 18, 2023
Expectation vs. Reality: study maps the neurons that tell the difference
Jul 18, 2023
Mouse study sheds light on how antipsychotics work
Jan 14, 2023
Lassen sich Tiere mit Virtual-Reality-Brillen austricksen?
Dec 7, 2021
How sound changes sight
Nov 5, 2021
Congratulations to the winners of the FMI Science Prizes 2021
All group news

Resources

Georg Keller

Mechanisms of psychiatric treatments

We aim to understand the mechanisms that give rise to conscious perception and how these mechanisms are disrupted in psychiatric disorders. Our laboratory is dedicated to exploring the neuronal circuit basis of conscious perception and investigating how these circuits become dysregulated in disease. Specifically, we focus on the effects of consciousness-altering drugs, widely used in psychiatric treatments, on the mouse cortex. 

Despite the extensive use of antipsychotic and antidepressant medications, surprisingly little is understood about their effect on neuronal activity. By identifying functional patterns in cortical activity that are common across drugs within the same category — independent of their receptor binding profiles — we aim to isolate the treatment-relevant changes induced by these drugs. This approach may reveal the core neural changes necessary for therapeutic efficacy. Ultimately, we aspire to leverage this understanding to develop alternative strategies for achieving similar therapeutic outcomes, potentially paving the way for more effective and targeted treatments.

 

 

 

Contact
Georg Keller



This is a list of selected publications from this group. For a full list of publications, please visit our Publications page and search by group name.


Georg B. Keller and Philipp Sterzer (2024) Predictive Processing: A Circuit Approach to Psychosis

Annual Review of Neuroscience Volume 47

Baba Yogesh, Georg B Keller (2024) Cholinergic input to mouse visual cortex signals a movement state and acutely enhances layer 5 responsiveness

eLife.89986.5

Matthias Heindorf, Georg B Keller (2024) Antipsychotic drugs selectively decorrelate long-range interactions in deep cortical layers

eLife 12:RP86805

Rebecca Jordan, Georg B Keller (2023) The locus coeruleus broadcasts prediction errors across the cortex to promote sensorimotor plasticity

eLife.85111.3

Sean M. O'Toole, Hassana K. Oyibo, Georg B. Keller (2023) Molecularly targetable cell types in mouse visual cortex have distinguishable prediction error responses

Neuron, Volume 111, Issue 18, 2918 - 2928.e8

Felix C Widmer, Sean M O'Toole, Georg B Keller (2022) NMDA receptors in visual cortex are necessary for normal visuomotor integration and skill learning

eLife 11:e71476

Aleena R. Garner and Georg B. Keller (2022) A cortical circuit for audio-visual predictions.

Nature Neuroscience 25: 98-105

Rebecca Jordan, Georg B. Keller (2020) Opposing influence of top-down and bottom-up input on excitatory layer 2/3 neurons in mouse primary visual cortex.

Neuron 108(6):1194-1206.e5.

Georg B. Keller, Thomas D. Mrsic-Flogel (2018) Predictive Processing: A Canonical Cortical Computation

Neuron 100: issue 2, P424-435

Heindorf M, Arber S, Keller GB (2018) Mouse Motor Cortex Coordinates the Behavioral Response to Unpredicted Sensory Feedback

Neuron 99:1040-1050.e5

Leinweber M, Ward DR, Sobczak JM, Attinger A, Keller GB (2017) A sensorimotor circuit in mouse cortex for visual flow predictions

Neuron 95:1420-1432.e5

Attinger A*, Wang B*, Keller GB (2017) Visuomotor coupling shapes the functional development of mouse visual cortex

Cell 169:1291-1302.e14
*equal contribution

Keller AJ, Houlton R, Kampa BM, Lesica NA, Mrsic-Flogel TD, Keller GB*, Helmchen F* (2017) Stimulus relevance modulates contrast adaptation in visual cortex

Elife 6. doi:10.7554/eLife.21589
* equal contributions

Zmarz P, Keller GB (2016) Mismatch receptive fields in mouse visual cortex

Neuron 92:766-772

Fiser A*, Mahringer D*, Oyibo HK*, Petersen AV, Leinweber M, Keller GB (2016) Experience-dependent spatial expectations in mouse visual cortex

Nat Neurosci. 19:1658-1664
* equal contributions

Liebscher S, Keller GB, Goltstein PM, Bonhoeffer T, Hübener M (2016) Selective persistence of sensorimotor mismatch signals in visual cortex of behaving Alzheimer's disease mice

Curr Biol 26:956-964

Leinweber M*, Zmarz P*, Argast P, Buchmann P, Hübener M, Bonhoeffer T, Keller GB (2014) Two-photon calcium imaging in mice navigating a virtual reality environment

J Vis Exp 84:e50885, doi:10.3791/50885
* equal contributions

Keller GB, Bonhoeffer T, Hübener M (2012) Sensorimotor mismatch signals in primary visual cortex of the behaving mouse

Neuron 74:809-815

Keller GB, Hahnloser RHR (2009) Neural processing of auditory feedback during vocal practice in a songbird

Nature 457:187-90

Full list of publications
» Search with Medline

Members

Group leader

In current position since 2012
» Contact details


PhD students

In current position since 2024
» Contact details

In current position since 2020
» Contact details

In current position since 2024
» Contact details

In current position since 2022
» Contact details

In current position since 2022
» Contact details

In current position since 2023
» Contact details

In current position since 2021
» Contact details


Postdoctoral fellows

In current position since 2024
» Contact details

In current position since 2023
» Contact details

In current position since 2021
» Contact details

In current position since 2024
» Contact details


Technical/Research associates

In current position since 2023
» Contact details

In current position since 2018
» Contact details


Visiting scientists

In current position since 2021
» Contact details


Alumni

PhD students

Baba Yogesh (2017-2023)
Felix Widmer (2016-2021)
Marina Moric (2017-2020)
David Mahringer (2013-2019)
Alexander Attinger (2013-2018)
Matthias Heindorf (2017)
Pawel Zmarz (2012-2017)
Bo Wang (2012-2017)
Aris Fiser (2013-2017)

Postdoctoral fellows

Sean O'Toole (2017-2023)
Matthias Heindorf (2017-2023)
Rebecca Jordan (2018-2023)
Aleena Garner (2016-2022)
Hassana Oyibo (2014-2022)
Koshika Yadava (2020-2021)
Marcus Leinweber (2012-2019)
Aris Fiser (2018-2019)
Daniel Ward (2014-2015)

Technical/Research associates

Daniela Gerosa Erni (2012-2020)

Undergraduates

Alice Schildkamp (2024)
Angelina Gaudry (2024)
Ahmed Aizi (2023)
Alice Schildkamp (2023)
Mar Boleda Pellicer (2023)
Leonora Pinter (2023)
Ahmed Aizi (2022)
Beatriz Lucia Saenz de Buruaga Corrochano (2022)
Cedric Moser (2020-2022)
Jan Sobczak (2014-2016)
Felix Widmer (2015)
Alexander Attinger (2013)
Ulisses Marti-Mengual (2013)

Visiting scientists

Mahesh Karnani (2020-2023)
Andreas Keller (2020-2023)
Anders Petersen (2015-2016)
Kareny Dominguez (2013)

Education

2009
PhD, Institute of Neuroinformatics, University of Zurich, ETH Zürich
2005
MSc, Swiss Federal Institute of Technology (ETH), Zürich

Positions held

2017-
Senior Group Leader, Friedrich Miescher Institute for Biomedical Research, Basel, Switzerland
2012-2017
Junior Group Leader, Friedrich Miescher Institute for Biomedical Research, Basel, Switzerland
2009-2012
Postdoctoral Fellow, Max Planck Institute of Neurobiology

Honors

2020
ERC Consolidator Grant
2015
ERC Starting Grant
2014
Human Frontier Science Program Career Development Award
2013
Max Planck Institute of Neurobiology Young Scientist Award
2010-2013
Human Frontier Science Program Long-term Fellowship
2009-2010
Swiss National Science Foundation Fellowship for Prospective Researchers