Jun 29, 2022
Video: watching how cells deal with stress
Dec 14, 2020
Thinking afresh about how cells respond to stress
Dec 16, 2019
A new druggable step in the gene expression pathway
Jan 28, 2019
How do mRNAs deal with stress?
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Jeffrey A. Chao
Regulation of gene expression
Gene expression requires an orchestrated series of events that is regulated temporally and spatially within the cell. After transcription, an mRNA must be spliced, processed, exported, transported and translated before it is eventually degraded. At each step, the factors that control the fate of the mRNA in either the nucleus or cytoplasm must be appropriately assembled, disassembled or remodeled. Not only is the composition of these macromolecular complexes dynamic, but there are also over 2000 proteins in the human genome involved in RNA metabolism, which makes them extremely heterogeneous as well. In order to better understand the molecular underpinnings that regulate these processes and how these complexes function within their cellular context, our research combines biochemical and structural (X-ray crystallography) techniques with single-molecule imaging of mRNAs in living cells.
Jeffrey A. Chao
This is a list of selected publications from this group. For a full list of publications, please visit our Publications page and search by group name.
Mateju, D., Eichenberger, B., Voigt, F. Eglinger, J., Roth, G., Chao, J.A. (2020) Single-molecule imaging reveals translation of mRNAs localized to stress granules.Cell. 183(7):1801-12.
Bhaskar, V., Graff-Meyer, A., Schenk, A., Cavadini, S., von Loeffhelholz, O., Natchiar, S.K., Artus-Revel, C., Hotz, H., Klaholz, B., Chao, J.A. (2020) Dynamics of uS19 C-terminal tail during the translation elongation cycle in human ribosomesCell Reports. 31(1):107473
Wilbertz, J.H., Voigt, F. Horvathova, I., Roth, G. Zhan, Y., Chao, J.A. (2019) Single-molecule imaging of mRNA localization and regulation during the integrated stress responseMol Cell. 73(5): 946-985
Horvathova I, Voigt F, Kotrys AV, Zhan Y, Artus-Revel CG, Eglinger J, Stadler MB, Giorgetti L, Chao JA (2017) The dynamics of mRNA turnover revealed by single-molecule imaging in single cellsMol Cell 68:615-625
Halstead JM, Lionnet T, Wilbertz JH, Wippich F, Ephrussi A, Singer RH, Chao JA (2015) An RNA biosensor for imaging the first round of translation from single cells to living animalsScience 347:1367-1370
Full list of publications
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