Jeffrey A. Chao

Group News

Dec 14, 2020
Thinking afresh about how cells respond to stress
Dec 16, 2019
A new druggable step in the gene expression pathway
Jan 28, 2019
How do mRNAs deal with stress?
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Publication Workflows and Data

Jeffrey A. Chao

Regulation of gene expression

Gene expression requires an orchestrated series of events that is regulated temporally and spatially within the cell. After transcription, an mRNA must be spliced, processed, exported, transported and translated before it is eventually degraded. At each step, the factors that control the fate of the mRNA in either the nucleus or cytoplasm must be appropriately assembled, disassembled or remodeled. Not only is the composition of these macromolecular complexes dynamic, but there are also over 2000 proteins in the human genome involved in RNA metabolism, which makes them extremely heterogeneous as well. In order to better understand the molecular underpinnings that regulate these processes and how these complexes function within their cellular context, our research combines biochemical and structural (X-ray crystallography) techniques with single-molecule imaging of mRNAs in living cells.

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Jeffrey A. Chao

Members

Group leader

In current position since 2013
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PhD students

In current position since 2018
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In current position since 2020
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In current position since 2019
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In current position since 2018
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Postdoctoral fellows

In current position since 2015
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In current position since 2018
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In current position since 2021
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In current position since 2018
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In current position since 2021
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In current position since 2015
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Technical/Research associates

In current position since 2012
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Visiting scientists

In current position since 2021
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Alumni

PhD students

Min Jia (2014-2019)
Johannes Wilbertz (2013-2018)
Ivana Horvathova (2013-2018)

Postdoctoral fellows

Min Jia (2019)
James Halstead (2014-2016)

Undergraduates

Nadia Djabeur (2020-2021)
Oleg Bedich (2020)
Bastian Eichenberger (2018-2020)
Desiree Triebold (2017-2018)
Julia Noerpel (2018)
Jahnavi Bhaskaran (2017)
Desiree Triebold (2016)
Mathilde Bedin (2016)
Anna Victoria Kotrys (2015)
Mathilde Bedin (2014)
Mathilde Bedin (2013)

Visiting scientists

Yoko Ogura (2019)
Denisa Jansova (2018)
Min Jia (2013-2014)

Education

2005
PhD, The Scripps Research Institute, La Jolla, CA, USA
1999
BA, Pomona College, Claremont, CA, USA

Positions held

2019-
Senior Group Leader, Friedrich Miescher Institute for Biomedical Research, Basel
2013-2019
Junior Group Leader, Friedrich Miescher Institute for Biomedical Research, Basel
2005-2012
Research Fellow, Albert Einstein College of Medicine, Bronx, NY, USA

Honors

2017
EMBO Young Investigator Award
2010
Dennis Shields Postdoctoral Research Prize
2007-2009
NIH NRSA Fellowship
2002-2005
Skaggs Pre-doctoral Fellowship
2000-2005
ARCS Scholar Fellowship