Prisca Liberali

Group News

Mar 8, 2024
Prisca Liberali receives International Suffrage Science Award
May 22, 2023
Video: Embryo-like models help map early stages of development
Nov 30, 2022
Seeing is believing - interview with Prisca Liberali
Aug 22, 2022
Jumping into the unknown
Jun 24, 2022
Prisca Liberali awarded EMBO Gold Medal 2022
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Logic of life

Prisca Liberali

Design principles of tissue organization

Understanding the collective properties of multicellular systems and their patterns, including how such properties arise from single-cell behavior and their self-organization, is essential in order to elucidate fundamental biological processes, such as cell reprogramming and disease.

In these systems, the roles and the molecular mechanisms of cell-to-cell variability in highly regulated cellular activities, like signal transduction, membrane trafficking and cytoskeleton dynamics have been poorly characterized.

Our laboratory develops and applies experimental and theoretical frameworks for the study of cellular heterogeneity during collective cell behavior. We use high-content genetic perturbation screens with single-cell resolution combined with advanced quantitative imaging and single-cell modeling of stem cells in 2D culture and 3D self-organizing systems. One of these systems is the development of 3D intestinal organoids from single stem cells.

This systems biology approach is used to unravel the determinants of pattern formation and to achieve a comprehensive understanding of the sources of cell-to-cell variability, and how this cell-to-cell variability affects the in vivo multicellular programming of cells.

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Prisca Liberali





This is a list of selected publications from this group. For a full list of publications, please visit our Publications page and search by group name.


Lukonin I, Serra D, Challet Meylan L, Volkmann K, Baaten J, Zhao, R Meeusen S, Colman K, Maurer F, Stadler MB, Jenkins J, Liberali P (2020) Phenotypic landscape of intestinal organoid regeneration.

Nature. 586, 275-280

Zinner M*, Lukonin I*, Liberali P (2020) Design principles of tissue organisation: How single cells coordinate across scales.

Current Opinion in Cell Biology. 67, 37-45

Yang Q, Xue SL, Chan CJ, Rempfler M, Vischi M, Maurer-Gutierrez F, Hiiragi T, Hannezo E, Liberali P (2020) Cell fate coordinates mechano-osmotic forces in intestinal crypt morphogenesis.

bioRxiv 2020.05.13.094359

Yang Q, Oost KC, Liberali P (2020) Engineering human knock-in organoids.

Nat Cell Biol. 22, 261-263

Mayr U*, Serra D*, Liberali P. (2019) Exploring single cells in space and time during tissue development, homeostasis and regeneration.

Development. 2019 Jun 27;146(12)

Serra D*, Mayr U*, Boni A*, Lukonin I, Rempfler M, Challet Meylan L, Stadler MB, Strnad P, Papasaikas P, Vischi D, Waldt A, Roma G, Liberali P. (2019) Self-organization and symmetry breaking in intestinal organoid development.

Nature. 569, 66-72

Welling M, Mohr MA, Ponti A, Rullan Sabater L, Boni A, Kawamura YK, Liberali P, Peters AH, Pelczar P, Pantazis P. (2019) Primed Track, high-fidelity lineage tracing in mouse pre-implantation embryos using primed conversion of photoconvertible proteins.

Elife doi: 10.7554/eLife.44491.

Xavier da Silveira Dos Santos A, Liberali P (2018) From single cells to tissue self-organization

FEBS J. 2018 Nov 3. doi: 10.1111/febs.14694

Gut G, Tadmor MD, Pe'er D, Pelkmans L, Liberali P. (2015) Trajectories of cell-cycle progression from fixed cell populations

Nat Methods. doi: 10.1038/nmeth.3545. [Epub ahead of print]

Liberali P, Snijder B, Pelkmans L (2015) Single-cell and multivariate approaches in genetic perturbation screens

Nat Rev Genet, 16:18-32

Liberali P*, Snijder B, Pelkmans L* (2014) A hierarchical map of regulatory genetic interactions in membrane trafficking

Cell, 157:1473-87
*corresponding authors

Snijder B, Liberali P, Frechin M, Stoeger T, Pelkmans L (2013) Predicting functional gene interactions with the hierarchical interaction score

Nat Methods, 10:1089-92

Liberali P, Pelkmans L (2012) Towards quantitative cell biology

Nat Cell Biol, 14:1233

Snijder B, Sacher R, Rämö P, Damm EM, Liberali P, Pelkmans L (2009) Population context determines cell-to-cell variability in endocytosis and virus infection

Nature, 461:520-3

Liberali P, Rämö P, Pelkmans L (2008) Protein kinases: starting a molecular systems view of endocytosis

Annu Rev Cell Dev Biol, 24:501-23

Liberali P, Kakkonen E, Turacchio G, Valente C, Spaar A, Perinetti G, Böckmann RA, Corda D, Colanzi A, Marjomaki V, Luini A (2008) The closure of Pak1-dependent macropinosomes requires the phosphorylation of CtBP1/BARS

EMBO J, 27:970-81

Full list of publications
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Members

Group leader

In current position since 2015
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PhD students

In current position since 2019
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In current position since 2021
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In current position since 2023
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In current position since 2020
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In current position since 2023
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In current position since 2020
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In current position since 2021
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Postdoctoral fellows

In current position since 2022
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In current position since 2022
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In current position since 2020
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In current position since 2020
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In current position since 2020
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Technical/Research associates

In current position since 2018
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In current position since 2021
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In current position since 2022
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Undergraduates

In current position since 2024
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In current position since 2023
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Visiting scientists

In current position since 2023
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Alumni

External scientific collaborators

Daniel Baeschlin (2016)

PhD students

Marietta Zinner (2016-2021)
Urs Mayr (2016-2019)
Denise Serra (2015-2019)
Ilya Lukonin (2015-2019)

Postdoctoral fellows

Qiutan Yang (2017-2022)
Chiara Azzi (2021-2022)
Marietta Zinner (2021-2022)
Gustavo Quintas Glasner de Medeiros (2018-2021)
Aline Xavier da Silveira dos Santos (2015-2019)
Andrea Boni (2016-2017)
Stefan Uhlmann (2015)

Technical/Research associates

Joel Luethi (2022-2023)
Dario Vischi (2017-2021)
Francisca Maurer (2015-2021)
Raphael Ortiz (2021)
Markus Herrmann (2017)

Undergraduates

Elisabetta Adamo (2023)
Alexis Haan (2022)
Kedar Krishnan (2022)
Emma Streutker (2021-2022)
Mirjam Verbeek (2021-2022)
Laurianne Temime (2021)
Simon Suppinger (2020-2021)
Jan-Daniel de Leede (2020-2021)
Silvia Barbiero (2020)
Robin Rothenfluh (2019-2020)
Anna Bailach Adsuara (2018-2019)
Jacqueline Staehlin (2015-2016)

Visiting scientists

Shicong Xie (2020)
Claudia Keller (2018)
Saadia Iftikhar (2015-2017)

Education

2008
PhD, Department of Cell Biology and Oncology, Mario Negri Sud, Italy
2004
Diploma, Department of Physical Organic Chemistry, University 'La Sapienza', Rome, Italy

Positions held

2021-
Senior group leader, FMI
2015-2021
Junior group leader, Friedrich Miescher Institute for Biomedical Research, Basel, Switzerland
2015-
Assistant Professor, University of Basel, Switzerland
2011-2014
Postdoctoral fellow, Institute of Molecular Life Sciences, University of Zurich, Switzerland
2008-2011
Postdoctoral fellow, Institute of Molecular Systems Biology, ETH, Zurich, Switzerland

Honors

2022
EMBO member
2022
EMBO Gold Medal
2021
Morphology Prize (awarded by the Swiss Society of Anatomy and Embryology)
2021
Friedrich Miescher Award (awarded by LS2)
2019
EMBO Young Investigator
2018-2023
European Research Council (ERC) Starting Grant
2015-2020
Swiss National Science Foundation, Professorship
2008-2011
FEBS long-term fellowship
2005-2008
Italian Association for Cancer Research (AIRC) fellowship
2004-2005
Italian Federation for Cancer Research (FIRC) fellowship