Prisca Liberali
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May 22, 2023 Video: Embryo-like models help map early stages of development |
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Nov 30, 2022 Seeing is believing - interview with Prisca Liberali |
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Aug 22, 2022 Jumping into the unknown |
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Jun 24, 2022 Prisca Liberali awarded EMBO Gold Medal 2022 |
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Jun 21, 2021 Mini-guts reveal crucial forces that shape the intestinal lining |
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Prisca Liberali
Design principles of tissue organization
Understanding the collective properties of multicellular systems and their patterns, including how such properties arise from single-cell behavior and their self-organization, is essential in order to elucidate fundamental biological processes, such as cell reprogramming and disease.
In these systems, the roles and the molecular mechanisms of cell-to-cell variability in highly regulated cellular activities, like signal transduction, membrane trafficking and cytoskeleton dynamics have been poorly characterized.
Our laboratory develops and applies experimental and theoretical frameworks for the study of cellular heterogeneity during collective cell behavior. We use high-content genetic perturbation screens with single-cell resolution combined with advanced quantitative imaging and single-cell modeling of stem cells in 2D culture and 3D self-organizing systems. One of these systems is the development of 3D intestinal organoids from single stem cells.
This systems biology approach is used to unravel the determinants of pattern formation and to achieve a comprehensive understanding of the sources of cell-to-cell variability, and how this cell-to-cell variability affects the in vivo multicellular programming of cells.
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Prisca Liberali
This is a list of selected publications from this group. For a full list of publications, please visit our Publications page and search by group name.
Lukonin I, Serra D, Challet Meylan L, Volkmann K, Baaten J, Zhao, R Meeusen S, Colman K, Maurer F, Stadler MB, Jenkins J, Liberali P (2020) Phenotypic landscape of intestinal organoid regeneration.
Nature. 586, 275-280Zinner M*, Lukonin I*, Liberali P (2020) Design principles of tissue organisation: How single cells coordinate across scales.
Current Opinion in Cell Biology. 67, 37-45Yang Q, Xue SL, Chan CJ, Rempfler M, Vischi M, Maurer-Gutierrez F, Hiiragi T, Hannezo E, Liberali P (2020) Cell fate coordinates mechano-osmotic forces in intestinal crypt morphogenesis.
bioRxiv 2020.05.13.094359Yang Q, Oost KC, Liberali P (2020) Engineering human knock-in organoids.
Nat Cell Biol. 22, 261-263Mayr U*, Serra D*, Liberali P. (2019) Exploring single cells in space and time during tissue development, homeostasis and regeneration.
Development. 2019 Jun 27;146(12)Serra D*, Mayr U*, Boni A*, Lukonin I, Rempfler M, Challet Meylan L, Stadler MB, Strnad P, Papasaikas P, Vischi D, Waldt A, Roma G, Liberali P. (2019) Self-organization and symmetry breaking in intestinal organoid development.
Nature. 569, 66-72Welling M, Mohr MA, Ponti A, Rullan Sabater L, Boni A, Kawamura YK, Liberali P, Peters AH, Pelczar P, Pantazis P. (2019) Primed Track, high-fidelity lineage tracing in mouse pre-implantation embryos using primed conversion of photoconvertible proteins.
Elife doi: 10.7554/eLife.44491.Xavier da Silveira Dos Santos A, Liberali P (2018) From single cells to tissue self-organization
FEBS J. 2018 Nov 3. doi: 10.1111/febs.14694Gut G, Tadmor MD, Pe'er D, Pelkmans L, Liberali P. (2015) Trajectories of cell-cycle progression from fixed cell populations
Nat Methods. doi: 10.1038/nmeth.3545. [Epub ahead of print]Liberali P, Snijder B, Pelkmans L (2015) Single-cell and multivariate approaches in genetic perturbation screens
Nat Rev Genet, 16:18-32Liberali P*, Snijder B, Pelkmans L* (2014) A hierarchical map of regulatory genetic interactions in membrane trafficking
Cell, 157:1473-87*corresponding authors
Snijder B, Liberali P, Frechin M, Stoeger T, Pelkmans L (2013) Predicting functional gene interactions with the hierarchical interaction score
Nat Methods, 10:1089-92Liberali P, Pelkmans L (2012) Towards quantitative cell biology
Nat Cell Biol, 14:1233Snijder B, Sacher R, Rämö P, Damm EM, Liberali P, Pelkmans L (2009) Population context determines cell-to-cell variability in endocytosis and virus infection
Nature, 461:520-3Liberali P, Rämö P, Pelkmans L (2008) Protein kinases: starting a molecular systems view of endocytosis
Annu Rev Cell Dev Biol, 24:501-23Liberali P, Kakkonen E, Turacchio G, Valente C, Spaar A, Perinetti G, Böckmann RA, Corda D, Colanzi A, Marjomaki V, Luini A (2008) The closure of Pak1-dependent macropinosomes requires the phosphorylation of CtBP1/BARS
EMBO J, 27:970-81Full list of publications
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