Selma Dahmane

Cellular and molecular basis of virus-induced inflammation

Our lab investigates the structures and molecular mechanisms underlying the interactions between RNA viruses and the host innate immune system. Viruses possess a remarkable ability to hijack cellular machinery, rapidly replicate and, within hours, infect other cells. Our innate immune system deploys various defense mechanisms against these intruders, including the formation of the inflammasome - a complex of proteins which plays a key role in secreting inflammatory cytokines. Tight control of inflammasome assembly is crucial for its protective function, as dysregulated inflammatory response will exacerbate virus pathogenesis. Our lab is interested in understanding how the inflammasomes detect viruses and how they assemble and disassemble within the virus-infected cell. To achieve this, we adopt a multidisciplinary approach, integrating cell biology and biochemistry assays, advanced microscopy techniques such as in vitro cryo-electron microscopy and in situ cryo-electron tomography to visualize inflammasome-virus interactions directly within the cell, and single-molecule microscopies to study the dynamic of its assembly.

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Selma Dahmane

This is a list of selected publications from this group. For a full list of publications, please visit our Publications page and search by group name.

Dahmane, S*., Schexnaydre, E.*, Zhang, J.*, Rosendal, E., Chotiwan, N., Kumari Singh, B., Yau, W. L., Lundmark, R., Barad, B., Grotjahn, D. A., Liese, S., Carlson, A., Overby, A., & Carlson, L. A. (2024) Cryo-electron tomography reveals coupled flavivirus replication, budding and maturation

bioRxiv
(* first authors)

Shankar, K., Sorin, M. N., Sharma, H., Skoglund, O., Dahmane, S., Ter Beek, J., Tesfalidet, S., Nenzén, L., & Carlson, L. A. (2024) ). In vitro reconstitution reveals membrane clustering and RNA recruitment by the enteroviral AAA+ ATPase 2C

PLoS Pathog, 20(8), e1012388

Wang, Y.*, Dahmane, S.*, Ti, R.*, Mai, X., Zhu, L., Carlson, L.-A., & Stjepanovic, G. (2024) Structural basis for lipid transfer by the ATG2A-ATG9A complex

Nature Structural & Molecular Biology
(* first authors)

Wang, Y.*, S. Dahmane*, R. Ti*, X. Mai, L. Zhu, L.-A. Carlson and G. Stjepanovic (2023) Structural basis for lipid transfer by the ATG2A-ATG9A complex

Nat Struct Mol Biol
(* first authors)

Shankar, K., M. N. Sorin, O. Skoglund, S. Dahmane, H. Sharma, J. t. Beek, L. Nenzen and L.-A. Carlson (2023) In vitro reconstitution reveals membrane clustering and double-stranded RNA recruitment by the enteroviral AAA+ ATPase 2C

PLoS Pathog

Dahmane, S., A. Kerviel, D. R. Morado, K. Shankar, B. Ahlman, M. Lazarou, N. Altan-Bonnet and L. A. Carlson (2022) Membrane-assisted assembly and selective secretory autophagy of enteroviruses.

Nat Commun 13(1): 5986.

S. Dahmane*, C. Doucet*, A. Le Gall, C. Chamontin, P. Dosset, F. Murcy, L. Fernandez, D. Salas, E. Rubinstein, M. Mougel, M. Nollmann and P. E. Milhiet (2019) Nanoscale organization of tetraspanins during HIV-1 budding by correlative dSTORM/AFM

Nanoscale 11(13): 6036-6044
(* first authors)

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