Silvia Arber
Group News
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Jul 26, 2021 More than just walking: a new role for core brain region |
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Apr 22, 2021 ERC Advanced Grant for Silvia Arber |
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Jan 6, 2021 Neuronal circuits for fine motor skills |
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Apr 28, 2020 Silvia Arber elected to the American National Academy of Sciences |
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Jun 1, 2019 Interview Werner Arber & Silvia Arber |
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Silvia Arber
Motor circuit function
Our studies aim at identifying the principles by which neuronal circuits orchestrate accurate and timely control of motor behavior. We thrive to understand how the nervous system can produce a large repertoire of movement patterns, covering diverse motor actions from locomotion to skilled forelimb tasks. To decipher how motor circuits engage in the control of movement and contribute to the generation of diverse actions, we unravel how neuronal subpopulations are organized into specific circuits, and we study the function of identified circuits in execution and learning of motor programs.
We address these questions using multi-facetted approaches combining many technologies. These include state-of-the-art mouse genetics, development and implementation of viral technologies for transsynaptic circuit tracing and functional manipulation by opto- and pharmacogenetics, quantitative behavioral analysis, electrophysiology and gene expression profiling of identified neuronal subpopulations.
The combination of these approaches allows us to assess connectivity and manipulate function in order to determine the role of defined circuit elements in animal behavior. Furthermore, they also enable us to uncover mechanisms involved in motor circuit assembly during development, as well as circuit plasticity during motor learning and in response to disease or injury.
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Silvia Arber
This is a list of selected publications from this group. For a full list of publications, please visit our Publications page and search by group name.
Manuel J. Ferreira-Pinto*, Harsh Kanodia*, Antonio Falasconi*, Markus Sigrist, Maria S. Esposito, and Silvia Arber (2021) Functional diversity for body actions in the mesencephalic locomotor region.
Cell [ePub ahead of print]Ludwig Ruder, Riccardo Schina, Harsh Kanodia, Sara Valencia-Garcia, Chiara Pivetta and Silvia Arber (2021) A functional map for diverse forelimb actions within brainstem circuitry.
Nature 590, 445-450Ruder L, Arber S (2019) Brainstem Circuits Controlling Action Diversification.
Annu Rev Neurosci. 42:485-504Takeoka A, Arber S (2019) Functional Local Proprioceptive Feedback Circuits Initiate and Maintain Locomotor Recovery after Spinal Cord Injury.
Cell Rep 27(1):71-85.e3Ferreira-Pinto MJ, Ruder L, Capelli P, Arber S. (2018) Connecting Circuits for Supraspinal Control of Locomotion.
Neuron 100(2):361-374Heindorf M, Arber S, Keller GB (2018) Mouse Motor Cortex Coordinates the Behavioral Response to Unpredicted Sensory Feedback
Neuron 99:1040-1050.e5Capelli P, Pivetta C, Soledad Esposito M, Arber S (2017) Locomotor speed control circuits in the caudal brainstem
Nature 551, 373-377Ruder L, Takeoka A, Arber S. (2016) Long-distance descending spinal neurons ensure quadrupedal locomotor stability
Neuron 92:1063-1078Satoh D, Pudenz C, Arber S (2016) Context-dependent gait choice elicited by EphA4 mutation in Lbx1 spinal interneurons
Neuron 89:1046-1058Basaldella E, Takeoka A, Sigrist M, Arber S (2015) Multisensory signaling shapes vestibulo-motor circuit specificity
Cell 163:301-312Goetz C, Pivetta C, Arber S (2015) Distinct limb and trunk premotor circuits establish laterality in the spinal cord
Neuron 85:131-144Takeoka A, Vollenweider I, Courtine G, Arber S (2014) Muscle spindle feedback directs locomotor recovery and circuit reorganization after spinal cord injury
Cell 159:1626-1639Esposito MS, Capelli P, Arber S (2014) Brainstem nucleus MdV mediates skilled forelimb motor tasks
Nature 508:351-356Pivetta C, Esposito MS, Sigrist M,Arber S (2014) Motor-circuit communication matrix from spinal cord to brainstem neurons revealed by developmental origin
Cell 156:537-548Arber S (2012) Motor circuits in action: specification, connectivity, and function
Neuron 74:975-989Tripodi M, Arber S (2012) Regulation of motor circuit assemblyby spatial and temporal mechanisms
Curr Opin Neurobiol 22:615-623Tripodi M, Stepien AE, Arber S (2011) Motor antagonism exposed by spatial segregation and timing of neurogenesis
Nature. 479:61-66Stepien AE, Tripodi M, Arber S (2010) Monosynaptic rabies virus reveals premotor network organization and synaptic specificity of cholinergic partition cells
Neuron 68:456-472Pecho-Vrieseling E, Sigrist M, Yoshida Y, Jessell TM, Arber S (2009) Specificity of sensory-motor connections encoded by Sema3e-Plxnd1 recognition
Nature 459:842-6Ladle DR, Pecho-Vrieseling E, Arber S (2007) Assembly of motor circuits in the spinal cord: driven to function by genetic and experience-dependent mechanisms
Neuron 56:270-283Kramer I, Sigrist M, de Nooij JC, Taniuchi I, Jessell TM, Arber S (2006) A role for Runx transcription factor signaling in dorsal root ganglion sensory neuron diversification
Neuron 49:379-393Vrieseling E, Arber S (2006) Target-induced transcriptional control of dendritic patterning and connectivity in motor neurons by ETS gene Pea3
Cell 127:1439-1452Hippenmeyer S, Vrieseling E, Sigrist M, Portmann T, Laengle C, Ladle DR, Arber S (2005) A developmental switch in the response of DRG neurons to ETS transcription factor signaling
PLoS Biol. 3:e159Full list of publications
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