Andreas Lüthi
Group News
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May 26, 2021 ‘Tug of war’ between neurons tells the brain when to fear — and when not to be afraid |
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Mar 3, 2021 'Brain state' behind social interaction uncovered |
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Mar 24, 2020 Research group of Andreas Lüthi receives Swiss Brain League Research Prize 2020 |
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Oct 22, 2019 A fundamental neuronal microcircuit for learning |
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Apr 23, 2019 Stressed, anxious? Ask the brain! |
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Andreas Lüthi
Cellular mechanisms of learning and memory
Experience-dependent changes in behavior are mediated by long-term functional modifications in brain circuits. We are interested in understanding the underlying mechanisms at the molecular, cellular and circuit levels. As a model system, we are using classical (Pavlovian) fear conditioning, a simple form of associative learning that is particularly suitable for study in rodents.
The inability to control or inhibit inappropriate fear responses is a hallmark of human anxiety disorders. We are investigating the cellular mechanisms underlying fear extinction, an associative learning process mediating inhibitory control of inappropriate fear behavior.
Using a multidisciplinary and integrated experimental approach in mice, we are combining in vitro and in vivo electrophysiology, imaging, molecular biology, genetics, and behavioral techniques to identify the synaptic and cellular constituents of neural circuits in the amygdala underlying the acquisition, encoding and extinction of fear memory - the microcircuitry of fear conditioning.
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Andreas Lüthi
This is a list of selected publications from this group. For a full list of publications, please visit our Publications page and search by group name.
Jan Gründemann*, Yael Bitterman*, Tingjia Lu, Sabine Krabbe, Benjamin F. Grewe, Mark J. Schnitzer & Andreas Lüthi (2019) Amygdala Ensembles Encode Behavioral States
Science, Vol. 364, Issue 6437, eaav8736* Co-first authors -- Publication available open access
Fadok JP, Krabbe S, Markovic M, Courtin J, Xu C, Massi L, Botta P, Bylund K, Müller C, Kovacevic A, Tovote P, Lüthi A (2017) A competitive inhibitory circuit for selection of active and passive fear responses
Nature 542, 96-100Grewe BF, Gründemann J, Kitch LJ, Lecoq JA, Parker J, Marshall JD, Larkin MC, Jercog P, Grenier F, Li JZ, Lüthi A, Schnitzer MJ (2017) Neural ensemble dynamics underlying long-term associative memory
Nature 543, 670-675Xu C, Krabbe S, Gründemann J, Botta P, Fadok JP, Osakada F, Saur D, Grewe BF, Schitzer MJ, Callaway EM, Lüthi A (2016) Distinct hippocampal pathways mediate dissociable roles of context in memory retrieval
Cell 167:961-972Vogel E*, Krabbe S*, Gründemann J, Wamsteeker Cusulin JI, Lüthi A (2016) Projection-specific dynamic regulation of inhibition in amygdala micro-circuits
Neuron 91: 644-651* Co-first author
Tovote P*, Esposito MS*, Botta P, Chaudun F, Fadok JP, Markovic M, Wolff SBE, Ramakrishnan C, Fenno L, Deisseroth K, Herry C, Arber S, Lüthi A (2016) Midbrain circuits for defensive behavior
Nature 534:206-212* Co-first author
Botta P, Demmou L, Kasugai Y, Markovic M, Xu C, Fadok JP, Lu T, Poe MM, Xu L, Cook JM, Rudolph U, Sah P, Ferraguti F, Lüthi A (2015) Regulating anxiety with extrasynaptic inhibition
Nature Neurosci 18:1493-1500Wolff SBE*, Gründemann J*, Tovote P, Krabbe S, Jacobson GA, Xu C, Müller C, Herry C, Ehrlich I, Friedrich RW, Letzkus JJ, Lüthi A (2014) Amygdala interneuron subtypes control fear learning through disinhibition
Nature 509:453-458*Co-first author
Senn V*, Wolff SBE*, Herry C, Grenier F, Ehrlich I, Gründemann J, Fadok JP, Müller C, Letzkus JJ, Lüthi A (2014) Long-range connectivity defines behavioral specificity of amygdala neurons
Neuron 81: 428-437*Co-first author
Letzkus JJ*, Wolff SBE*, Meyer EMM, Tovote P, Courtin J, Herry C, Lüthi A (2011) A disinhibitory microcircuit for associative fear learning in auditory cortex
Nature 480: 331-335*Co-first author
Ciocchi S*, Herry C*, Grenier F, Wolff SBE, Letzkus, JJ, Vlachos I, Ehrlich I, Sprengel R, Deisseroth K, Stadler M, Müller C, Lüthi A (2010) Encoding of conditioned fear in central amygdala inhibitory circuits
Nature 468: 277-282*Co-first author
Haubensak W, Kunwar P, Cai H, Ciocchi S, Wall N, Ponnusami R, Biag J, Dong HW, Deisseroth K, Callaway EM, Fanselow MS, Lüthi A, Anderson DJ (2010) Genetic dissection of an amygdala microcircuit that gates conditioned fear
Nature 468: 270-276.Gogolla N, Caroni P, Lüthi A, Herry C (2009) Perineuronal nets protect fear memories from erasure
Science 325:1258-1261Fourcaudot E*, Gambino F*, Humeau Y, Casassus G, Poulain B, Lüthi A (2009) L-type voltage-dependent Ca2+ channels mediate expression of presynaptic LTP in amygdala
Nature Neurosci 12:1093-1095*Co-first author
Herry C, Ciocchi S, Senn V, Demmou L, Müller C, Lüthi A (2008) Switching on and off fear by distinct neuronal circuits
Nature 454:600-606Shaban H, Humeau Y, Herry C, Casassus G, Shigemoto R, Ciocchi S, Barbieri, S, van der Putten H, Kaupmann K, Bettler B, Lüthi A (2006) Generalization of amygdala LTP and conditioned fear in the absence of presynaptic inhibition
Nature Neurosci 9:1028-1035Humeau Y, Herry C, Kemp N, Shaban H, Fourcaudot E, Bissiere S, Lüthi A (2005) Dendritic spine heterogeneity determines afferent-specific hebbian plasticity in the amygdala
Neuron 45:119-131Humeau Y, Shaban H, Bissière S, Lüthi A (2003) Presynaptic induction of heterosynaptic associative plasticity in the mammalian brain
Nature 426:841-845Bissière S, Humeau Y, Lüthi A (2003) Dopamine gates LTP induction in lateral amygdala by suppressing feedforward inhibition
Nature Neurosci 6:587-592Full list of publications
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Nikolas was born in Athens, Greece, where he studied Applied Mathematics and Physics. He had always been fascinated by the complexity of the human brain, so he decided to shift his focus to Neuroscience. He joined the Neurasmus Master’s program in Neuroscience in Berlin and Bordeaux. During his PhD he worked with Prof. Anton Sirota to investigate the role of breathing in entraining neuronal dynamics and engaged in the large-scale characterization of the oscillatory architecture of memory circuits.
Current reseachNikolas is working on the neuromodulation of amygdala circuits during behavior. Using a combination of fiber photometry and large-scale electrophysiological recordings, Nikolas is investigating the role of neuromodulators in coordinating amygdala circuits during behavior.
Education- Ph.D. in Neuroscience - Ludwig-Maximilians Universität München
- M.Sc. in Neuroscience (Charité, Berlin & Université de Bordeaux II)
- B.Sc, M.Sc in Applied Mathematics and Physics (NTUA)
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Tobias was born in Alsace, on the French side of the tri-national urban area of Basel. He did his studies in Strasbourg, before joining the Oncology Department at Novartis, as a postgraduate student. He worked in the pharmacology unit, where he performed PK/PD and efficacy studies on tumor models. He then joined the FMI in 2013 as a Research Associate in the lab of Momo Bentires-Alj. His main project was to identify new therapeutic targets in the field of breast cancer, using an in vivo mutagenesis screening tool. He then got the opportunity to join the Neurobiology Department of the FMI in the lab of Andreas Lüthi, where he is working since 2016 as a Lab Manager.
Education • MSc in Pharmacology, University of Strasbourg
• BSc in Cellular Biology and Physiology, University of Strasbourg
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