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A novel pathway ensuring chromosome stability in early mice embryo
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|Stem Cell Center of Competence|
Antoine H.F.M. Peters
Intergenerational and developmental epigenetics
Through the modulation of chromatin states, epigenetic mechanisms contribute to the reading of genetic information. Classically, epigenetic regulators are known to play conserved roles in the heritability of cell identity during somatic differentiation and in genome stability. More recent studies have shown that certain epigenetic modifiers also regulate the maintenance of differentiation potential and self-renewal capacity in stem cells.
Remarkably little is known about the epigenetic mechanisms regulating the acquisition of totipotency and subsequent lineage specification during early mammalian development. In mammals, fusion of an oocyte and a spermatozoon, two differentiated and transcriptionally silent germ cells, leads to the formation of the totipotent embryo. Based on nuclear transfer experiments, we and others suggested that epigenetic reprogramming occurring during gametogenesis facilitates re-acquisition of totipotency in early embryos. This hypothesis argues for a transgenerational epigenetic contribution towards early development.
Our research aims at obtaining a molecular understanding of the role of distinct epigenetic pathways in the control of gene regulation and lineage specification in pre-implantation embryos. We further investigate the functional significance of transmission of histone modifications for gene activity or repression in the subsequent generation.
Antoine H.F.M. Peters
This is a list of selected publications from this group. For a full list of publications, please visit our Publications page and search by group name.
Stäubli A. and A.H.F.M. Peters (2021) Mechanisms of maternal intergenerational epigenetic inheritance.Current Opinion in Genetics & Developmental 67: 151-162 (open access).
Liu Z., Tardat M., Gill M., Royo H., Thierry R., Ozonov E.A. and A.H.F.M Peters (2020) SUMOylated PRC1 controls histone H3.3 deposition and genome integrity of embryonic heterochromatin.EMBO Journal 39: e103697 (open access)
Du Z.*, Zheng H.*, Kawamura Y.K.*, Zhang K.*, Gassler J., Powell S., Xu Q., Lin Z., Xu K., Zhou Q., Ozonov E.A., Véron N., Huang B., Li L., Yu G., Liu L., Au Yeung W.K., Wang P., Chang L., Wang Q., He A., Sun Y., Na J., Sun Q., Sasaki H., Tachibana K., Peters A.H.F.M. # and W. Xie# (2020) Polycomb Group Proteins Regulate Chromatin Architecture in Mouse Oocytes and Early Embryos.Molecular Cell 77(4): 825-839
Shared *first and # corresponding authorships.
Leonards K.*, Almosailleakh M.*,Tauchmann S.*, Otzen Bagger F.*, Thirant C., Juge S., Bock T., Mereau H., Bezzera M., Tzankov A., Ivanek R., Losson R., Peters A.H.F.M., Mercher T., and J. Schwaller (2020) Nuclear interacting SET domain protein 1 inactivation impairs GATA1-regulated erythroid differentiation and causes erythroleukemia.Nat Commun 11, 2807 (open access)
* shared first authorship
Mark E. Gill, Antoine H. F. M. Peters (2018) Toward human egg-like cells in vitroScience 362/ 6412: 291-292
Stavropoulou V, Kaspar S, Brault L, Sanders MA, Juge S, Morettini S, Tzankov A, Iacovino M, Lau IJ, Milne TA, Royo H, Kyba M, Valk PJ, Peters AH*, Schwaller J* (2016) MLL-AF9 expression in hematopoietic stem cells drives a highly invasive AML expressing EMT-related genes linked to poor outcomeCancer Cell 30:43-58
* shared corresponding authorship
Eymery A, Liu Z*, Ozonov EA*, Stadler MB, Peters AH (2016) The methyltransferase Setdb1 is essential for meiosis and mitosis in mouse oocytes and early embryosDevelopment 143:2767-2779
* shared authorship
Royo H, Stadler MB*, Peters AH* (2016) Alternative computational analysis shows no evidence for nucleosome enrichment at repetitive sequences in mammalian spermatozoaDev Cell 37:98-104
* shared corresponding authorship
Siklenka K*, Erkek S*, Godmann M, Lambrot R, McGraw S, Lafleur C, Cohen T, Xia J, Suderman M, Hallett M, Trasler J, Peters AHFM#, Kimmins S# (2015) Disruption of histone methylation in developing sperm impairs offspring health transgenerationallyScience 350:aab2006
* co-first authorship and # corresponding authors
Tardat M*, Albert M*, Kunzmann R, Liu Z, Kaustov L, Thierry R, Duan S, Brykczynska U, Arrowsmith CH, Peters AHFM (2015) Cbx2 targets PRC1 to constitutive heterochromatin in mouse zygotes in a parent-of-origin-dependent mannerMol Cell 58:157-7
* co-first authorship
van de Werken C, van der Heijden GW, Eleveld C, Teeuwssen M, Albert M, Baarends WM, Laven JS, Peters AHFM, Baart EB (2014) Paternal heterochromatin formation in human embryos is H3K9/HP1 directed and primed by sperm-derived histone modificationsNat Commun 5:5868
Hisano M, Erkek S, Dessus-Babus S, Ramos L, Stadler MB, Peters AHFM (2013) Genome-wide chromatin analysis in mature mouse and human spermatozoaNature Protocol 8:2449-2470
Erkek S, Hisano M, Liang C-Y, Gill M, Murr R, Dieker J, Schübeler D, van der Vlag J, Stadler MB, Peters AHFM (2013) Molecular determinants of nucleosome retention at CpG-rich sequences in mouse spermatozoaNat Struct Mol Biol 20: 868-875
Yokobayashi S, Liang C-Y, Kohler H, Nestorov P, Liu Z, Vidal M, van Lohuizen M, Roloff TC, Peters AHFM (2013) PRC1 coordinates timing of sexual differentiation of female primordial germ cellsNature 495: 236-240
Posfai E, Kunzmann R, Brochard V, Salvaing J, Cabuy E, Roloff TC, Liu Z, Tardat M, van Lohuizen M, Vidal M, Beaujean N, Peters AHFM (2012) Polycomb function during oogenesis is required for mouse embryonic developmentGenes Dev 26:920-32
Gill ME, Erkek S, Peters AHFM (2012) Parental epigenetic control of embryogenesis: a balance between inheritance and reprogramming?Curr Opin Cell Biol 24:387-96
Brykczynska U, Hisano M, Erkek S, Ramos L, Oakeley EJ, Roloff TC, Beisel C, Schübeler D, Stadler MB, Peters AHFM (2010) Repressive and active histone methylation mark distinct promoters in human and mouse spermatozoaNat Struct Mol Biol 17:679-687
Puschendorf M, Terranova R, Boutsma E, Mao X, Isono KI, Brykczynska U, Kolb C, Otte AP, Koseki H, Orkin SH, van Lohuizen M, Peters AHFM (2008) PRC1 and Suv39h specify parental asymmetry at constitutive heterochromatin in early mouse embryosNat Genet 40:411-420
This paper is highlighted in: Packer A (2008) Epigenetics: across the generations. Nat Rev Gen 9:248-249
Terranova R, Yokobayashi S, Stadler MB, Otte AP, van Lohuizen M, Orkin SH, Peters AHFM (2008) Polycomb group proteins Ezh2 and Rnf2 direct genomic contraction and imprinted repression in early mouse embryosDev Cell 15:668-679
This paper is highlighted in: Wu H-U, Bernstein E (2008) Partners in imprinting: non-coding RNA and polycomb group proteins. Dev Cell 15:637-638
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