Guillaume Diss


Guillaume Diss will be joining the FMI and start the laboratory on March 1st, 2019. He is currently setting up his group and welcomes applications for PhD and postdoc positions.
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Quantitative and mechanistic models of genotype-phenotype maps

Our research focuses on understanding the mechanisms through which genetic variation translates into phenotypic variation, e.g. diseases or functional innovations. A cell is an ensemble of molecules that interact together and form a complex network of molecular interactions. This network organizes biological processes and cellular functions and determines the phenotype of the cell. Mutations quantitatively perturb the way proteins interact with each other and with other molecules. This in turn perturbs the architecture of the network and the complex and dynamic equilibrium between biological processes, which can result in a phenotypic change.

We will combine quantitative genetics, biochemistry and systems biology approach together with modeling and computational biology to develop quantitative and mechanistic models of mutation effects. We will measure the effects of mutations at different levels of organization, from single genes (expression, protein stability, enzymatic activity) to molecular interactions (protein-protein, protein-nucleic acids) and network architecture. We will then use this data to generate our models. Strong focus will be placed on understanding the mechanisms through which the effects of mutations depend upon additional genetic variation (i.e. epistasis), uncovering the general principles of biological organization and of its evolution.


2014 PhD, Department of Biology, Université Laval, Québec City, Canada
2009 MSc Molecular and Structural Biology, Université de Strasbourg, France

Positions held
2019- Junior Group Leader; Friedrich Miescher Institute for Biomedical Research, Basel, Switzerland
2014-2019 Postdoctoral Fellow; Center for Genomic Regulation, Barcelona, Spain

2015-2018 Marie Sklodowska-Curie Fellowship (Impulse/COFUND).
EMBO Fellowship, declined
2014 Excellence award, Department of Biology, Université Laval
Étudiants-chercheurs étoiles award, Government of Quebec
2013 Fonds Richard Bernard award.
Société Provancher award
2011 PROTEO Fewllowship
2006 International Exchange Scholarship, Région Alsace
International Exchange Scholarship, Université Louis Pasteur


Domingo J, Diss G and Lehner B (2018) Pairwise and higher order genetic interactions during the evolution of a tRNA. Nature. 558:117-121.

Diss G and Lehner B. (2018) The genetic landscape of a physical interaction. eLife. 7:e32472

Diss G, Gagnon-Arsenault I, Dion-Coté AM, Vignaud H, Ascencio DI, Berger CM, Landry CR. (2017) Gene duplication can impart fragility, not robustness, in the yeast protein interaction network. Science. 355:630-634.

Filteau M*, Diss G*, Torres-Quiroz F et al. (2015) Systematic identification of signal integration by Protein Kinase A. Proc Nat Acad Sci. 112:4501-6.

Diss G, Ascencio D, Deluna A, Landry CR. (2014) Molecular mechanisms of paralogous compensation and the robustness of cellular networks. J Exp Zool B Mol Dev Evol. 322:488-99.

Diss G, Dubé AK, Boutin J, Gagnon-Arsenault I, Landry CR. (2013) A systematic approach for the genetic dissection of protein complexes in living cells. Cell Reports. 3(6):2155-67.

Diss G*, Filteau M*, Freschi L*, Leducq JB*, Rochette S*, Torres-Quiroz F*, Landry CR. (2013) Integrative avenues for exploring the dynamics and evolution of protein interaction networks. Curr Op Biotechnol. 24(4):775-83.

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