Ruth Chiquet-Ehrismann
Ruth Chiquet-Ehrismann
Obituary Ruth Chiquet-Ehrismann (1954 - 2015)
The Friedrich Miescher Institute for Biomedical Research shares its sorrow at the sudden and unexpected death of Ruth Chiquet-Ehrismann, Senior group leader of the FMI and Adjunct professor of the University of Basel, on September 4, 2015. With her passing we have lost a very special colleague.
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Cell communication in growth control and differentiation
Normal development depends on cell-cell and cell-extracellular matrix (ECM) interactions. Cancer cells are impaired in cell adhesion and have lost the ability to respond properly to their environment, which results in overgrowth and metastatic behavior. In contrast to the ECM of normal tissues, tumor ECM contains markedly increased amounts of tenascin-C and less fibronectin. Therefore, we investigate the anti-adhesive and tumor growth-promoting functions of the ECM protein family of tenascins. We analyze the interaction between tenascins and fibronectin and the intracellular signaling pathways in- duced by cell adhesion to these ECM proteins. We have discovered a novel cell surface receptor family that we have termed teneurins. These are transmembrane proteins with a cytoplasmic domain involved in signal transduction and a large extracellular part involved in cell-cell interactions. We are studying their function in adhesion signaling that regulates cell survival, proliferation and differentiation. We use molecular and cell biological techniques with cell cultures and with chicken and Caenorhabditis elegans for in vivo studies.
Scharenberg MA, Pippenger BE, Sack R, Zingg D, Ferralli J, Schenk S, Martin I, Chiquet-Ehrismann R (2014) TGF-β-induced differentiation into myofibroblasts involves specific regulation of two MKL1 isoforms
J Cell Sci 127:1079-1091Gurbuz I, Ferralli J, Roloff T, Chiquet-Ehrismann R, Asparuhova MB (2014) SAP domain-dependent Mkl1 signaling stimulates proliferation and cell migration by induction of a distinct gene set indicative of poor prognosis in breast cancer patients
Mol Cancer 13:22Tucker RP, Ferralli J, Schittny JC, Chiquet-Ehrismann R (2013) Tenascin-C and tenascin-W in whisker follicle stem cell niches: possible roles in regulating stem cell proliferation, migration and differentiation.
J Cell Sci 126:5111-5115Beckmann J, Schubert R, Chiquet-Ehrismann R, Müller DJ (2013) Deciphering teneurin domains that facilitate cellular recognition, cell-cell adhesion and neurite outgrowth using AFM-based single-cell force spectroscopy
Nano Lett 13:2937-2946Brellier F, Martina E, Degen M, Heuzé-Vourch N, Petit A, Kryza T, Courty Y, Terracciano L, Ruiz C, Chiquet-Ehrismann R (2012) Tenascin-W is a better cancer biomarker than tenascin-C for most human solid tumors
BMC Clin Pathol 12:14Martina E, Degen M, Rüegg C, Merlo A, Lino MM, Chiquet-Ehrismann R, Brellier F (2010) Tenascin-W is a specific marker of glioma-associated blood vessels and stimulates angiogenesis in vitro
FASEB J 24:778-87Sivasankaran B, Degen M, Ghaffari A, Hegi ME, Hamou MF, Ionescu MC, Zweifel C, Tolnay M, Wasner M, Mergenthaler S, Miserez AR, Kiss R, Lino MM, Merlo A, Chiquet-Ehrismann R, Boulay JL (2009) Tenascin-C is a novel RBPJkappa-induced target gene for Notch signaling in gliomas
Cancer Res 69:458-65Tucker RP, Chiquet-Ehrismann R (2009) The regulation of tenascin expression by tissue microenvironments
Biochim Biophys Acta 1793:888-92Tucker RP, Chiquet-Ehrismann R (2009) Evidence for the evolution of tenascin and fibronectin early in the chordate lineage
Int J Biochem Cell Biol 41:424-34Degen M, Brellier F, Schenk S, Driscoll R, Zaman K, Stupp R, Tornillo L, Terracciano L, Chiquet-Ehrismann R, Rüegg C, Seelentag W (2008) Tenascin-W, a new marker of cancer stroma, is elevated in sera of colon and breast cancer patients
Int J Cancer 122:2454-61Kenzelmann D, Chiquet-Ehrismann R, Leachman NT, Tucker RP (2008) Teneurin-1 is expressed in interconnected regions of the developing brain and is processed in vivo
BMC Dev Biol 25:30Trzebiatowska A, Topf U, Sauder U, Drabikowski K, Chiquet-Ehrismann R (2008) Caenorhabditis elegans teneurin, ten-1, is required for gonadal and pharyngeal basement membrane integrity and acts redundantly with integrin ina-1 and dystroglycan dgn-1
Mol Biol Cell 19:3898-908Degen M, Brellier F, Kain R, Ruiz C, Terracciano L, Orend G, Chiquet-Ehrismann R (2007) Tenascin-W is a novel marker for activated tumor stroma in low-grade human breast cancer and influences cell behavior
Cancer Res 67:9169-9179Tucker RP, Kenzelmann D, Trzebiatowska A, Chiquet-Ehrismann R (2007) Teneurins: transmembrane proteins with fundamental roles in development
Int J Biochem Cell Biol 39:292-297Tucker RP, Chiquet-Ehrismann R (2006) Teneurins: a conserved family of transmembrane proteins involved in intercellular signaling during development
Dev Biol 290:237-245Drabikowski K, Trzebiatowska A, Chiquet-Ehrismann R (2005) ten-1, an essential gene for germ cell development, epidermal morphogenesis, gonad migration, and neuronal pathfinding in Caenorhabditis elegans
Dev Biol 282:27-38Nunes-Radimerski S, Ferralli J, Choi KD, Minet A, Chiquet-Ehrismann R (2005) The intracellular domain of teneurin-1 interacts with MBD1 and CAP/ponsin resulting in subcellular co-distribution and translocation to the nuclear matrix
Exp Cell Res 305:122-132Scherberich A, Tucker RP, Degen M, Brown-Luedi M, Andrès AC, Chiquet-Ehrismann R (2005) (2005) Tenascin-W is found in malignant mammary tumors, promotes alpha8 integrin-dependent motility and requires p38MAPK activity for BMP-2 and TNF-alpha induced expression in vitro
Oncogene 24:1525-1532Ruiz C, Huang W, Hegi ME, Lange K, Hamou M-F, Fluri E, Oakeley EJ, Chiquet-Ehrismann R, Orend G (2004) Differential gene expression analysis reveals activation of Wnt and MAPK signaling and downregulation of tropomyosin-1 by tenascin-C
Cancer Res 64:7377-7385Scherberich A, Tucker RP, Samandari E, Brown-Luedi M, Martin D, Chiquet-Ehrismann R (2004) Murine tenascin-W: A novel mammalian tenascin expressed in kidney and at sites of bone and smooth muscle development
J Cell Sci 117:571-581Bagutti C, Forro G, Ferralli J, Rubin Lucht B, Chiquet-Ehrismann R (2003) The intracellular domain of teneurin-2 has a nuclear function and represses zic-1 mediated transcription
J Cell Sci 116:2957-2966Chiquet-Ehrismann R, Chiquet M (2003) Tenascins: regulation and putative functions during pathological stress
J Pathol 200:488-499